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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | The Soil-Borne Identity and Microbiome-Assisted Agriculture:Looking Back to the Future显示文摘Looking forward includes looking back every now and then.In 2007,David Weller looked back at 30 years of biocontrol of soil-borne pathogens by Pseudomonas and signified that the progress made over decades of research has provided a firm foundation to formulate current and future research questions.It has been recognized for more than a century that soil-borne microbes play a significant role in plant growth and health.The recent application of high-throughput omics technologies has enabled detailed dissection of the microbial players and molecular mechanisms involved in the complex interactions in plant-associated microbiomes.Here,we highlight old and emerging plant microbiome concepts related to plant disease control,and address perspectives that modern and emerging microbiomics technologies can bring to functionally characterize and exploit plant-associated microbiomes for the benefit of plant health in future microbiome-assisted agriculture. | Peter A.H.M.Bakker Roeland L.Berendsen Johan A.Van Pelt Gilles Vismans Ke Yu Erqin Li Sietske Van Bentum Sanne W.M.Poppeliers Juan J.Sanchez Gil Hao Zhang Pim Goossens Ioannis A.Stringlis Yang Song Ronnie de Jonge CornéM.J.Pieterse | 2020 | Molecular Plant2020，13，10： | 3 |
| 3 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 4 | 果蔬摄入与乳腺癌发病风险的关系显示文摘背景:人们一直认为,摄人蔬菜和水果可预防乳腺癌的发生。相关证据大多来自病例对照研究。但是,最近有人对零星发表的队列研究进行了汇总分析,提示摄人蔬菜和水果并不能显著降低乳腺癌的发病风险。 | Carla H. van Gils Petra H. M. Peeters H. Bas Bueno-de-Mesquita 顾佳(译) | 2005 | 美国医学会杂志(中文版)2005，24，4： | 2 |
| 5 | Fatigue in children and adolescents with inflammatory bowel disease显示文摘AIM To identify factors other than active disease and anemia that contribute to fatigue in pediatric inflammatory bowel disease(IBD).METHODS We performed an electronic search in Medline and EMBASE from their inception to May 2017 using the search term 'fatigue' or the related keywords 'physical impairment' and 'inflammatory bowel disease' with the filter 'child'(age 0-18 years). Cross-sectional and case-control studies were included. We restricted our search to studies published in English. We used the PRISMA checklist and flow diagram. Duplicate articles were manually deleted in End Note. To identify further relevant studies, we checked the reference lists of the selected articles.RESULTS We identified 149 papers, of which 19 were retrieved for full text review. Eleven studies were subsequently excluded because fatigue was not evaluated as an outcome measure. Eight papers focused on the desired topic and were discussed in the final analysis. A lack of uniformity of outcome measures made the pooling of data impossible. In all but one study, questionnaires were used to evaluate fatigue. In the remaining study, an accelerometer was used to measure daily activities, sleeping time and their relationships with fatigue in a more quantifiable manner. Adolescents with IBD are significantly more fatigued than healthy controls. In addition to active disease, increased anxiety or depression and disturbed family relationships were frequently reported predictors of fatigue. Quantitative measurement of physical activity in patients with Crohn's disease showed a reduction in the number of steps per day, and patients with ulcerative colitis had a shorter duration of physical activity during the day.CONCLUSION Fatigue in pediatric IBD is related to a combination of biological, functional and behavioral factors, which should all be taken into account when managing fatigue. | Els Van de Vijver Ann Van Gils Laura Beckers Yannick Van Driessche Nicolette Dorien Moes Patrick Ferry van Rheenen | 2019 | World Journal of Gastroenterology2019，25，5： | 2 |
| 6 | Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques :mech- anism for macrophage retention and survival 显示文摘 | RAMKHELAWON B YANG Y van GILS J M | 2013 | Arterioscler Thromb Vasc Biol2013，33，6： | 1 |
| 7 | The time -resolved fluorescencc- based PCA3 test on urinary sediments after digital rectal examination; a Dutch multicenter validation of the diagnostic performance 显示文摘 | Van Gils MP Hessels D van Hooij O | 2007 | Clin Cancer Res2007，13，： | 1 |
| 8 | Health monitoring in the home of the future显示文摘 | Korhonen I Parkka J Van Gils M | 2003 | IEEE EMB Magazine2003，22，3： | 1 |
| 9 | MRI findings of thoracolumbar spine fractures: a categorization based on MRI examination of 100 fractures显示文摘 | Van Gils AP Dhert WJ | 1999 | Skeletal Radiol1999，28，8： | 1 |
| 10 | Absorption of nitric oxide into aqueous solutions of ferrous chelate accompanied by instantaneous reaction显示文摘 | DEMMINK J F VAN GILS I C BEENACKERS A A | 1997 | Industrial and Engineering Chemistry Research1997，36，： | 1 |
| 11 | Research Working Paper Series 显示文摘 | Marco Van Gelderen Maryse Brand Mirjam Van Praag Wynand Bodewes Erik Poutsma Anita van Gils | 2006 | Department of Management and International Business2006，，2： | 1 |
| 12 | Temporoal lobe epilepsy: the various MR appearances of histologically proven mesial temporal selerosis显示文摘 | Meiners LC van Gils A Jansen GH | 1994 | AJNR1994，15，： | 1 |
| 13 | DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk 显示文摘 | Stern MC Umbach DM van Gils CH | 2001 | Cancer Epidemiol Biomarkers Prev2001，10，2： | 1 |
| 14 | Carotid atherosclerotic plaque progression and change in plaque composition over time: 5-year follow-up study using serial CT angiography 显示文摘 | van Gils MJ Vukadinovic D van Dijk AC | 2012 | Am J Neuroradiol2012，33，7： | 1 |
| 15 | Carotid atherosclerotic plaque progression and change in plaque composition over time:a5_year follow_up study using serial CT angiography显示文摘 | Van Gils M Vukadinovic D van Dijk A | 2012 | Am J Neuroradiol2012，33，7： | 1 |
| 16 | MRI findings of thoracolumbar spine fractures:a categorisation based on MRi examinations of 100 fractures 显示文摘 | Oner FC van Gils AP Dhert WJ | 1999 | Skeletal Radiol1999，28，8： | 1 |
| 17 | Temporal lobe epilepsy: the various MR appearances of histologically proven mesial temporal sclerosis 显示文摘 | Meiners LC van Gils A Jansen GH et ol | 1994 | Am J Neuroradiol1994，15，8： | 1 |
| 18 | Association between carotid artery plaque ulceration and plaque composition evaluated with multide- tector CT angiography 显示文摘 | Homburg PJ Rozie S van Gils M J | 2011 | Stroke2011，42，2： | 1 |
| 19 | Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular disease 显示文摘 | VAN GILS J M ZWAGINGA J J HORDIJK P L | 2009 | J Leukoc Biol2009，85，2： | 1 |
| 20 | Association between carotid artery plaque ulceration and plaque composition evaluated with multideteetor CT angiography显示文摘 | Homburg PJ Rozie S van Gils M J | 2011 | Stroke2011，42，： | 1 |
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