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| 1 | High-definition colonoscopy with i-Scan:Better diagnosis for small polyps and flat adenomas显示文摘AIM:To investigate if high-definition (HD) colonoscope with i-Scan gave a higher detection rate of mucosal lesions vs standard white-light instruments. METHODS:Data were collected from the computerized database of the endoscopy unit of our tertiary referral center. We retrospectively analyzed 1101 consecutive colonoscopies that were performed over 1 year with standard white-light (n = 849) or HD+ with i-Scan (n = 252) instruments by four endoscopists, in an outpatient setting. Colonoscopy records included patients' main details and family history for colorectal cancer, indication for colonoscopy (screening, diagnostic or surveillance), type of instrument used (standard white-light or HD+ plus i-Scan), name of endoscopist and bowel preparation. Records for each procedure included whether the cecum was reached or not and the reason for failure, complications during or immediately after the procedure, and number, size, location and characteristics of the lesions. Polyps or protrudinglesions were defined as sessile or pedunculated, and nonprotruding lesions were defined according to Paris classification. For each lesion, histological diagnosis was recorded. RESULTS:Eight hundred and forty-nine colonoscopies were carried with the standard white-light video colonoscope and 252 with the HD+ plus i-Scan video colonoscope. The four endoscopists did 264, 300, 276 and 261 procedures, respectively; 21.6%, 24.0%, 21.7% and 24.1% of them with the HD+ plus i-Scan technique. There were no significant differences between the four endoscopists in either the number of procedures done or the proportions of each imaging technique used. Both techniques detected one or more mucosal lesions in 522/1101 procedures (47.4%). The overall number of lesions recognized was 1266; 645 in the right colon and 621 in the left. A significantly higher number of colonoscopies recognized lesions in the HD+ plus i-Scan mode (171/252 = 67.9%) than with the standard white-light technique (408/849 = 48.1%) (P < 0.0001). HD+ with i-Scan colonoscopies identified more lesions than standard white-light imaging (459/252 and 807/849, P < 0.0001), in the right or left colon (mean ± SD, 1.62 ± 1.36 vs 1.33 ± 0.73, P < 0.003 and 1.55 ± 0.98 vs 1.17 ± 0.93, P = 0.033), more lesions < 10 mm (P < 0.0001) or nonprotruding (P < 0.022), and flat polyps (P = 0.04). The cumulative mean number of lesions per procedure detected by the four endoscopists was significantly higher with HD+ with i-Scan than with standard white-light imaging (1.82 ± 2.89vs 0.95 ± 1.35,P < 0.0001). CONCLUSION:HD imaging with i-Scan during the withdrawal phase of colonoscopy significantly increased the detection of colonic mucosal lesions, particularly small and nonprotruding polyps. | Pier Alberto Testoni Chiara Notaristefano Cristian Vailati Milena Di Leo Edi Viale | 2012 | World Journal of Gastroenterology2012，18，37： | 12 |
| 2 | Fertility preservation in female cancer patients:a single center experience显示文摘Advances in cancer treatment allow women to be cured and live longer. However, the necessary chemotherapy and radiotherapy regimens have a negative impact on future fertility. Oncofertility has emerged as a new interdisciplinary field to address the issue of gonadotoxicity associated with cancer treatment and to facilitate fertility preservation, including oocyte and ovarian tissue cryopreservation. These fertility issues are often inadequately addressed, and referral rates to oncofertility centers are low. The aim of this study was to report the 3-year experience of the San Raffaele Oncofertility Unit. A total of 96 patients were referred to the Oncofertility Unit for evaluation after the diagnosis of cancer and before gonadotoxic treatment between April 2011 and June 2014. Of the 96 patients, 30(31.2%) were affected by breast cancers, 20(20.8%) by sarcomas, 28(29.2%) by hematologic malignancies, 13(13.5%) by central nervous system cancers, 3(3.1%) by bowel tumors, 1(1.0%) by Wilms' tumor, and 1(1.0%) by a thyroid tumor; 47(49.0%) were referred for oocyte cryopreservation before starting chemotherapy, 20(20.8%) were referred for ovarian tissue cryopreservation, and 29(30.2%) were not recruited. The mean time between the patients' counseling and oocyte retrieval was 15 days(range, 2–37 days). The mean time between the laparoscopic surgery and the beginning of treatment was 4 days(range, 2–10 days). The number of patients who were referred increased over time, whereas the rate of patients who were not recruited decreased, showing an improvement in referrals to the Oncofertility Unit and in the patients' counseling and understanding. Our results indicate that an effective multidisciplinary oncofertility team is necessary for prompt referrals and treatment. | Cristina Sigismondi Enrico Papaleo Paola Viganò Simona Vailati Massimo Candiani Jessica Ottolina Valentina E. Di Mattei Giorgia Mangili | 2015 | Chinese Journal of Cancer2015，34，1： | 7 |
| 3 | Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus显示文摘AIM To investigate the relationship between pathological oropharyngeal(OP) acid exposure and esophageal motility in patients with extra-esophageal syndromes.METHODS In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease(GERD). We enrolled only patients with a reflux symptom index(RSI) score-higher than 13 and with previous lung, allergy and ear, nose and throat evaluations excluding other specific diagnoses. All patients underwent 24-h OP pH-metry with the Dx probe and esophageal highresolution manometry(HRM). Patients were divided into two groups on the basis of a normal or pathological p H-metric finding(Ryan Score) and all manometric characteristics of the two groups were compared.RESULTS We examined 135 patients with chronic extra-esophageal syndromes. Fifty-one were considered eligible for the study. Of these, 42 decided to participate in the protocol. Patients were divided into two groups on the basis of normal or pathological OP acid exposure. All the HRM parameters were compared for the two groups. Significant differences were found in the median upper esophageal sphincter resting pressure(median 71 mmH g vs 126 mmH g, P = 0.004) and the median proximal contractile integral(median 215.5 cm·mmH g·s vs 313.5 cm·mmH g·s, P = 0.039), both being lower in the group with pathological OP acid exposure, and the number of contractions with small or large breaks, which were more frequent in the same group. This group also had a larger number of peristaltic contractions with breaks in the 20 mm Hg isobaric contour(38.7% vs 15.38%, P < 0.0001).CONCLUSION In patients with suspected GERD-related extraesophageal syndromes pathological OP acid exposure was associated with weaker proximal esophageal motility. | Sandro Passaretti Giorgia Mazzoleni Cristian Vailati Pier Alberto Testoni | 2016 | World Journal of Gastroenterology2016，22，40： | 5 |
| 4 | Outcome evaluation of early placed maxillary anterior single-tooth implants using objective esthetic criteria: a cross-sectional, retrospective study in 45 patients with a 2- to 4-year follow-up using pink and white esthetic scores 显示文摘 | Belser UC Grutter L Vailati F | 2009 | J Periodontol2009，80，1： | 1 |
| 5 | Outcome evaluation of early placed maxillary anterior single-tooth implants using objective esthetic: criteria: a cross-sectional,retrospective study in 45 patients with a 2- to 4-year follow-up using pink and white esthetic scores 显示文摘 | Belser U C Grutter L Vailati F | 2009 | J Periodontol2009，80，1： | 1 |
| 6 | Outcome evaluation of early placed maxillary anterior single-tooth implants using objective esthetic criteria:a cross-sectional,retrospective study in 45 patients with a 2 to 4 year follow-up using pink and white esthetic scores显示文摘 | Belser U C Grütter L Vailati F | 2009 | J Periodontol2009，80，1： | 1 |
| 7 | Outcome evaluation of early placed maxillary anterior single-tooth implants using objective esthetic criteria:a cross-sectional,retrospective study in 45 patients with a 2-to 4-year follow-up using pink and white esthetic scores显示文摘 | Belser UC Grutter L Vailati F | 2009 | J Periodontol2009，80，1： | 1 |
| 8 | Outcome evaluation of early placed maxillary anterior single-tooth implants using objective esthetic criteria : a cross-sectional, retrospective study in 45 patients with a 2- to 4-year follow-up using pink and white esthetic scores 显示文摘 | Belser UC Grtitter L Vailati F | 2009 | J Peri- odontol2009，80，1： | 1 |
| 9 | Outcome evaluation of early placed maxillary anterior single-tooth implants using objective esthetic criteria: a cross-sectional, retrospective study in 45 patients with a 2- to 4-year follow-up using pink and white esthetic scores 显示文摘 | Belser UC Griitter L Vailati F | 2009 | J Periodontol2009，80，1： | 1 |
| 10 | Outcome evaluation of early placed maxillary anterior single-tooth implants using objective esthetic criteria: across-sectional , retrospective study in 45 patients with a 2-to 4-year follow-up using pink and white esthetic scores 显示文摘 | Belser U C Grutter L Vailati F | 2009 | J Periodont2009，80，1： | 1 |
| 11 | Outcome evaluation of early placed maxillary anterior single-tooth implants using objective esthetic criteria: a cross-sectional, retrospective study in 45 patients with a 2- to 4-year follow-up using pink and white esthetic scores显示文摘 | Belser UC Griitter L Vailati F | 2009 | J Periodontol2009，80，1： | 1 |
| 12 | Outcome evaluation of early placed maxillary anterior single-tooth implants using objective es- thetic criteria: a cross-sectional, retrospective study in 45 patients with a 2- to 4-year follow-up using pink and white esthetic scores 显示文摘 | Belser UC Grutter L Vailati F | 2009 | J Periodontol2009，80，1： | 1 |
| 13 | Muscle and skin sympathetic nerve traffic during the 'white-coat' effect显示文摘 | GRASSI G TURRI C VAILATI S | 1999 | Circulation1999，100，3： | 1 |
| 14 | Paraquat induced embryotoxicity on Xenopus laevis development 显示文摘 | Vismara C Battista V Vailati G | 2000 | A- quatic Toxicology2000，49，3： | 1 |
| 15 | Muscle and skin sympathetic nerve traffic during the 'white-coat' effect显示文摘 | Grassi G Turri C Vailati S | 1999 | Cirulation1999，100，3： | 1 |
| 16 | Muscle and skin sympathetic nerve traffic during the white-coat effect 显示文摘 | Grassi G Turri C Vailati S et al | 1999 | Circulation1999，100，3： | 1 |
| 17 | Muscle and skin synpathetic nerve traffic during the white-coat effect显示文摘 | Grassi G Turri C Vailati S | 1999 | Circulation1999，100，3： | 1 |
| 18 | Outcome evaluation of early placed maxillary anterior single-tooth implants using objective esthetic criteria : a cross-sectional, retrospective study in 45 patients with a 2- to 4-year follow-up using pink and white esthetic scores 显示文摘 | Belser UC Grtitter L Vailati F | 2009 | J Peri- odontol2009，80，1： | 1 |
| 19 | Correlation between oropharyngeal pH-monitoring and esophageal pH-impedance monitoring in patients with suspected GERD-related extra-esophageal symptoms Passaretti S 显示文摘 | MAZZOLENI G VAILATI C LISMA DG | 2014 | Nenrogastroenteml Motil2014，26，11： | 1 |
| 20 | A method to assess benefits of transmission expansions in the Italian electricity market显示文摘 | Vaiani A Bresesti P Vailati R | 2007 | Power Engineering Society General Meeting2007，，： | 1 |
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