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| 1 | Neurodegeneration:An early event of diabetic retinopathy显示文摘Diabetic retinopathy(DR) has been classically considered to be a microcirculatory disease of the retina caused by the deleterious metabolic effects of hyperglycemia per se and the metabolic pathways triggered by hyperglycemia.However,retinal neurodegeneration is already present before any microcirculatory abnormalities can be detected in ophthalmoscopic examination.In other words,retinal neurodegeneration is an early event in the pathogenesis of DR which predates and participates in the microcirculatory abnormalities that occur in DR.Therefore,the study of the mechanisms that lead to neurodegeneration will be essential to identify new therapeutic targets in the early stages of DR.Elevated levels of glutamate and the overexpression of the renin-angiotensin-system play an essential role in the neurodegenerative process that occurs in diabetic retina.Among neuroprotective factors,pigment epithelial derived factor,somatostatin and erythropoietin seem to be the most relevant and these will be considered in this review.Nevertheless,it should be noted that the balance between neurotoxic and neuroprotective factors rather than levels of neurotoxic factors alone will determine the presence or absence of retinal neurodegeneration in the diabetic eye.New strategies,based on either the delivery of neuroprotective agents or the blockade of neurotoxic factors,are currently being tested in experimental models and in clinical pilot studies.Whether these novel therapies will eventually supplement or prevent the need for laser photocoagulation or vitrectomy awaits the results of additional clinical research. | Marta Villarroel Andreea Ciudin Cristina Hernández Rafael Simó | 2010 | World Journal of Diabetes2010，1，2： | 41 |
| 2 | On water security, sustainability, and the water-food-energy-climate nexus显示文摘在持续开发并且在水,食物,精力和气候相互作用的连结的水安全的角色从灰色和 Sadoff 提供的水安全的定义的起点被检验。关于安全的观点的大部分在要求满足人的需要的资源与缺乏的专横有关。因此,在主流的经济的缺乏的处理接着在我们中的每怎么与目的作为个人调解工具的关系被检验,在持续开发的想法的核心的一个过程。根据 Grey-Sadoff 定义,达到水安全数量到作为更多的将军,的一位先锋完成基本的、单个扇区的水开发自立, multi-sectoral 开发。这与水在平等者之中在被当作第一的方法一致,即给予优惠在考虑什么在在水的连结附近完成安全是关键的,食物,精力和气候。当然,城市是为这些要求多重资源精力流动逐渐地被产生的地点。纸讨论安全的二个重要方面,即,资源和服务的存取的差异(例如卫生) 并且在联合 human-built-natural 系统的行为的跳回。关于城市大楼和基础结构计量连结安全,八个伪运作的原则被开发。 | Michael Bruce BECK Rodrigo VILLARROEL WALKER | 2013 | Frontiers of Environmental Science & Engineering2013，7，5： | 3 |
| 3 | 影响奶牛休息时间的因素显示文摘之前的相关研究均表示奶牛的休息时间越长产奶越多,但想要诱使奶牛休息更长却非常困难。通过提高牧场条件进而增加奶牛的休息时间,大家进行了许多尝试和努力,从改善卧床到降低牛群密度等等。 | Aurora Villarroel Ben Krahn 熊倩(译者) 赵尊阳(审阅) | 2011 | 广东奶业2011，，1： | 2 |
| 4 | Water and nutrient and energy systems in urbanizing watersheds显示文摘 | Rodrigo VILLARROEL WALKER Michael Bruce BECKl, Jim W. HALL | 2012 | Frontiers of Environmental Science & Engineering2012，6，5： | 2 |
| 5 | The Arabidopsis functional homolog of P34cdc2 protein kinase显示文摘 | Ferreira P C Hemerly A S Villarroel R | | 0，，05： | 1 |
| 6 | Fluoxetine response in impulsive–aggressive behavior and serotonin transporter polymorphism in personality disorder显示文摘 | Hernán Silva Patricia Iturra Aldo Solari Juana Villarroel Sonia Jerez Marco Jiménez Felipe Galleguillos Maria Leonor Bustamante | 2010 | Psychiatric Genetics2010，，1： | 1 |
| 7 | Aminopeptidase activities,oxidative stress and renal function in Crotalus durissus terrificus envenomation in mice 显示文摘 | Yamasaki SC Villarroel JS Barone JM | 2008 | Toxicon2008，52，3： | 1 |
| 8 | Heavier alcohols synthesis on cobalt phyllosilicate catalysts显示文摘 | Loaiza-Gil A Arenas J Villarroel M | 2005 | Journal of Molecular Catalysis2005，228，12： | 1 |
| 9 | Effect of transport time on sensorial aspects of beef meat quality显示文摘 | Villarroel M Maria G A Safiudo C | 2003 | Meat Science2003，63，3： | 1 |
| 10 | Intersubunit cooperativity in the NMDA receptor显示文摘 | Regalado MP Villarroel A Lerma J | 2001 | Neuron2001，32，6： | 1 |
| 11 | Oral lichen planus: Immunohistology of mucosal lesions 显示文摘 | Villarroel Dorrego M ColTenti M Delgado R | 2002 | J Oral Pathol Med2002，31，7： | 1 |
| 12 | Muhiparameter Intelligent Monitoring in Intensive Care II: a public-access intensive care unit database显示文摘 | Saeed M Villarroel M Reisner AT | 2011 | Crit Care Med2011，39，： | 1 |
| 13 | Mycophenolatemofetil: An update 显示文摘 | VILLARROEL M C HIDALGO M JIMENO A | 2009 | Drugs today ( Bare)2009，45，7： | 1 |
| 14 | Enhancing mi- cro{iltration through an inorganic tubular membrane by gas sparging显示文摘 | Vera L Villarroel R Delgado S | 2000 | J Membr Sci2000，165，： | 1 |
| 15 | lntravenous and subcutaneous pharmacokinetics of florfenicol in sheep显示文摘 | Lane V M Villarroel A Wetzlich S E | 2004 | Journal of veterinary pharmacology and ther- apeutics2004，27，4： | 1 |
| 16 | Effect of Transport Time and Handling on Physiological Responses of Cattle显示文摘 | Girma Gebresenbet Isabel Wikner Emmanuel Yaovi Hunnuor Bobobee Gustavo Maria Morris Villarroel | 2012 | Journal of Agricultural Science and Technology(A)2012，2，6： | 1 |
| 17 | Glycine-indopmdaat NMDA receptor desensitization: localization of structural determinants显示文摘 | Villarroel A Regalado MP Lerma J | 1998 | Neuron1998，20，： | 1 |
| 18 | Daphnia magna feeding behavior after exposure to tetradifon and recovery from intoxication 显示文摘 | Villarroel M J Ferrando M D Andreu E | 1999 | Ecotoxicol Environ Saf1999，44，： | 1 |
| 19 | Acute, chronic and sublethal effects of the herbicide propanil on Daphnia magna显示文摘 | VILLARROEL M J SANCHO E M D FERRANDO M D | 2003 | Chemosphere2003，53，8： | 1 |
| 20 | Acute,chronic and sublethal effects of the herbicide propanil on Daphnia magna显示文摘 | Villarroel M J Sancho E Ferrando M D | 2003 | Chemosphere2003，53，8： | 1 |
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