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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 3 | Excitotoxic damage,disrupted energy metabolism,and oxidative stress in the rat brain:antioxidant and neuroprotective effects of L-carnitine显示文摘 | DANIELA S A VERONICA P D C MARA N H M | 2008 | Jonrnal of Neurochemistry2008，105，： | 1 |
| 4 | Degradation of chlorophenols by means of advanced oxidation processes: a general review 显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | Applied Catalysis B: Environmental2004，47，： | 1 |
| 5 | Struc-tural evolution of the Neogene Gar Basin,western Tibet:Implications for releasing bend development and drainagepattems显示文摘 | Veronica I S Michael A M William R D | 2010 | GSA Bulletin2010，122，56： | 1 |
| 6 | On the use of portfolio risk models and capital requirements in emerging markets:the case of Argentina显示文摘 | VERONICA B FALKENHEIM M POWELL A | 2002 | The World Bank Economic Review2002，，16： | 1 |
| 7 | Degradation of chlorophenols by means of advanced oxidation processes: a general review 显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | Applied Catalysis B : Environmental2004，47，4： | 1 |
| 8 | Olfactory responses of A naphes iole ( Hymenoptera : Mymaridae)to volatile signals derived from host habitats显示文摘 | Veronica M Walker A J Livy H W | 2005 | Journal of Insect Behavior2005，18，1： | 1 |
| 9 | Microbial community composition and enzyme activities in a sandy loam soil after fumigation with methyl bromide or alternative biocides 显示文摘 | Susanne K Veronica A M Husein A | 2006 | Soil Biology & Biochemistry2006，38，6： | 1 |
| 10 | Appli Cat B: Environ显示文摘 | Marc P T Veronica G M Miguel A B | 2004 | 47(4):219-2562004，47，4： | 1 |
| 11 | Antioxidant activity of o-bisphenols: the role of intramolecular hydrogen bonding 显示文摘 | Riccardo A Marco L Veronica M | 2003 | JOrgChem2003，68，13： | 1 |
| 12 | Immersion chilling of hot cut, vacuum packed pork primals显示文摘 | Brown T Gigiel A J Veronica M | 1988 | Meat Science1988，22，3： | 1 |
| 13 | Microbial com- munity composition and enzyme activities in a sandy loam soil after fumigation with methyl bromide or alter- native biocides显示文摘 | Susanne K Veronica A M Husein A | 2006 | Soil Biology & Biochemistry2006，38，6： | 1 |
| 14 | Ethanol steam reforming using Ni( Ⅱ)-Al(Ⅲ) layered double hydroxide as catalyst precursor kinetic study 显示文摘 | VERONICA M GRACIELA B NORMA A | 2008 | Chemical Engineering Journal2008，138，： | 1 |
| 15 | The humic acid analogue antraquinone-2,6-disulfonate (AQDS) serves as an electron shuttle in the electricity-driven microbial dechlorination of trichloroethene to cis-dichloroethene 显示文摘 | FEDERICO A VERONICA D M | 2010 | Bioresource Technology2010，101，24： | 1 |
| 16 | Olive oil and lemon salad dressing microencapsulated by freeze-drying显示文摘 | KELLY A SILVA MARIA ALICE Z COELHO VERONICA M A CALADO | 2013 | Food Science and Technology2013，50，2： | 1 |
| 17 | Enzyme activities as affectedby soil properties and land use in a tropical watershed显示文摘 | Veronica A M Leo C David S R | 2007 | Applied Soil Ecology2007，35，： | 1 |
| 18 | A First Class Knowledge Service: Developing the National Electronic Library for Health显示文摘 | Alison T Veronica F Gray J A M | 2012 | Health Information and Libraries Journal2012，，19： | 1 |
| 19 | Ethanol steam reforming using Ni(II)-AI(/II) layered double hydroxide as catalyst precursor kinetic study显示文摘 | Veronica M Graciela B Norma A et ol | 2008 | Chem Eng J2008，138，13： | 1 |
| 20 | Degrada- tion of chlorophenols by means of advanced oxidation pro- cessed-a general review显示文摘 | MARC P T VERONICA G M MIGUEL A B | 2004 | Applied Catalysis B: Environmen- tal2004，47，4： | 1 |
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