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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | 跟骨关节内移位骨折的功能疗效和患者满意度——切开复位、经皮手术和非手术治疗对比研究显示文摘对于跟骨关节内移位骨折,约60%的工薪阶层患者会选择切开复位内固定术(openreductionandinternalfixation,ORIF)治疗,术后恢复工作通常需要5~10个月,相当一部分患者1年内无法恢复工作;而对于保守治疗患者,骨折症状通常会持续1~2年,高达16%的患者需行关节内固定手术。本研究的主要目的是比较3种跟骨关节内移位骨折治疗方案——ORIF、经皮手术和非手术治疗的疗效差异。 | De Boer AS Van Lieshout EM Den Hartog D 叶翔凌 夏远军 | 2016 | 中国骨科临床与基础研究杂志2016，8，6： | 2 |
| 3 | Dendritic cells, Fe γ receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis 显示文摘 | Radstake TR van Lieshout AW van Riel PL | 2005 | Ann Rheum Dis2005，64，11： | 1 |
| 4 | Circulation CXCL16 is not related to circulation ox LDL in patients with rheumatoid arthritis 显示文摘 | van Lieshout AW Popa C Meyer-Wentrup F | 2007 | Boochem Biophys Res Commun2007，355，2： | 1 |
| 5 | MIF production by dendritic cells is differentially egulated by Toll-like receptors and increased during rheumatoid arthritis显示文摘 | Popa C van Lieshout A W Roelofs M F etal | 2006 | Cytokine2006，36，12： | 1 |
| 6 | Leg crossing improves orthostatic tolerance in healthy subjects:a placebo-controlled crossover study显示文摘 | Krediet CT van Lieshout JJ Bogert LW | 2006 | Am J Heart Circ Physiol2006，291，4： | 1 |
| 7 | Lactate fuels the human brain during exercise显示文摘 | Quistoff B Secher N H Van Lieshout J J | 2008 | FASEB J2008，22，10： | 1 |
| 8 | A review of candidate pathways underlying the association between asthma and major depressive disorder显示文摘 | Van Lieshout RJ Bienenstock J MacQueen GM | | 0，，02： | 1 |
| 9 | Neural circulatory control in vasovagal syncope显示文摘 | van Lieshout J Wieling W Karemaker JM | 1997 | PACE1997，20，： | 1 |
| 10 | Diabetes mellitus during pregnancy and increased risk of schizophrenia in offspring:a review of the evidence and putative mechanisms显示文摘 | Van Lieshout R J Voruganti LP | 2008 | J Psychiatry Neurosci2008，33，： | 1 |
| 11 | Calcaneal fracture classification: a comparative study 显示文摘 | Schepers T van Lieshout EM Ginai AZ | 2009 | J Foot Ankle Surg2009，48，2： | 1 |
| 12 | Mental health of extremely low birth weight survivors in their 30s 显示文摘 | Van Lieshout R J Boyle MH Saigal S | 2015 | Pediatrics2015，135，3： | 1 |
| 13 | Summary of the 'Thyroid disorders' guideline of the Dutch College of General Practitioners (NHG) 显示文摘 | Sijbom M van Lieshout J Felix-Schollaart B | 2013 | Ned Tijdschr Geneeskd2013，157，35： | 1 |
| 14 | Reputation manage-ment in agro-food industries:safety first显示文摘 | C M J van Woerkum Ir M van Lieshout | | 0，，05： | 1 |
| 15 | Immunodiagnosis of schistosomiasis mansoni in a low endemic area in Surinam by de- termination of the circulating antigens CAA and CCA 显示文摘 | Van Lieshout L Panday UG De Jonge N | 1995 | Acta Trop1995，59，1： | 1 |
| 16 | Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis显示文摘 | van Lieshout AW Fransen J Flendrie M | 2007 | Ann Rheum Dis2007，66，10： | 1 |
| 17 | Treatment of penetrating trauma of the extremities : ten years' experience at a Dutch level 1 trauma center 显示文摘 | Van Waes OJ Van Lieshout EM Hogendoorn W | 2013 | Scand J Trauma Resusc Emerg Med2013，21，： | 1 |
| 18 | Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints显示文摘 | van der Voort R van Lieshout AW Toonen LW | 2005 | Arthritis Rheum2005，52，5： | 1 |
| 19 | A reviewof candidate pathways underlying the association betweenasthma and major depressive disorder 显示文摘 | Van Lieshout RJ Bienenstock J MaeQueen GM | 2009 | PsychosomMed2009，71，2： | 1 |
| 20 | Stroke volume of the heart and thoracic fluid content durillg head-upand head-down tilt in humans 显示文摘 | Van Lieshout Harms M Pott F | 2005 | Acta Anaesthesiologica Scandin-avica2005，49，9： | 1 |
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