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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Experimental study on mass transfer from pyrolysing coal particles显示文摘 | Suuberg E M Unge P E Lilly W D | 1985 | Fuel1985，64，： | 1 |
| 3 | Effects of Cr3C2 on the microstruc- ture and mechanical properties of the brazed joints between WC-Co and carbon steel 显示文摘 | Lee W B Kwon B D ]ung S B | 2006 | Int J Refract Met Hard Mater2006，24，3： | 1 |
| 4 | Improving observervariability in target delineation for gastro-oesophageal cancer the role of (F) fluoro-2-deoxy-D-glucose positron emissiontomography/computed tomography 显示文摘 | Vesprini D Ung Y Dinniwell R | 2008 | Clin Oncol2008，20，8： | 1 |
| 5 | Laparoscopic abdominal radical trachelectomy显示文摘 | Cibula D Ungár L Pálfalvi L | | 0，，02： | 1 |
| 6 | Approximations and Reducts with Covering Generalized Rough Sets显示文摘 | Tsang E C De gang C Ye ung D S | 2008 | Computers and Mathematics with Applications2008，，56： | 1 |
| 7 | Model of piezoresistivity cement显示文摘 | WEN S in carbo search 2006 3 UNG D D L | 2006 | Cement and Concrete2006，6，10： | 1 |
| 8 | Making all the right connections : the strategic leadership of top executives in high-tech organizations显示文摘 | Sosik J J J ung D I Berson Y | 2005 | Organizational Dynamics2005，34，1： | 1 |
| 9 | Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT)1A1 genetic variants and SULT1E1显示文摘 | Ung D Nagar S | 2007 | Drug Metab Dispos2007，35，5： | 1 |
| 10 | Variable sulfation of dietary polyphenols byrecombinant human sulfotransferase(SULT)1A1 geneticvariants and SULT1E1显示文摘 | Ung D Nagar S | 2007 | Drug Metab Dispos2007，35，5： | 1 |
| 11 | Growth of magnetic nanowires and nanodumbbells in liquid polyol显示文摘 | Ung D Soumare Y Chakroune N | 2007 | Chemistry of Materials2007，19，8： | 1 |
| 12 | Identification of intedeukin- 1, tumor mecrosis factor-alpha, and interleukin-6 expression in lungs from pigs naturally infected with Mycoplasma hyopneu- moniae by in situ hybridization显示文摘 | Ahn K K Kwon D J ung K | 2009 | J Vet Med Sci2009，71，4： | 1 |
| 13 | Engineering of a bis-chelator motif into a protein a-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy显示文摘 | Swarbrick J D Ung P SU X C | 2011 | Chem Commun (Camb)2011，47，26： | 1 |
| 14 | An iminodiacetic acid based lanthanide binding tag for paramagnetic exchange NMR spectroscopy显示文摘 | Swarbrick J D Ung P Chhabra S | 2011 | Angew Chem Int Ed Engl2011，50，19： | 1 |
| 15 | Influence of social status on crown geometry and volume increment in regular and irregular black spruce stands显示文摘 | Raulier F Ung C H Ouellet D | 1996 | Can J For Res1996，28，： | 1 |
| 16 | Antifatigue effect of Rubus coreanus Miquel extract in mice显示文摘 | J ung K A Han D Kwon E K | 2007 | J Med Food2007，10，04： | 1 |
| 17 | KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT 显示文摘 | Panoskaltsis-Mortari A Ingbar D H J ung P | 2000 | Am J Physiol Lung Cell Mol Physiol2000，278，5： | 1 |
| 18 | Low tempertature synthesis oflnP nanocrystals 显示文摘 | Nguyen Q L Ung T D T Peter R | 2008 | Mater Chem Phys2008，112，3： | 1 |
| 19 | Optimising hot paths in a dynamic binary translator 显示文摘 | Ung D Cifuentes C | 2001 | ACM SIGARCH Computer Architecture News2001，29，1： | 1 |
| 20 | CoNi nanowires synthesized by heterogeneous nucleation in liquid polyol显示文摘 | Ung D Viau G Ricolleau C | 2005 | Advanced Materials2005，17，3： | 1 |
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