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| 1 | 欧洲新生儿呼吸窘迫综合征防治指南-2010版显示文摘呼吸窘迫综合征(RDS)是由于肺表面活性物质(PS)缺乏及肺结构发育不成熟所致,多见于早产儿,自然病程为生后当时或很快发病,并在生后2d内进行性恶化,如不及时治疗,因进行性缺氧和呼吸衰竭而死亡,存活者,在生后2—4d病情开始改善。胎龄越小,RDS发生率越高,2006年EuroNeoStat的数据显示:胎龄23~25周的早产儿RDS发生率为91%, | Sweet DG Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 袁琳(翻译) 陈超(审校) | 2011 | 中华儿科杂志2011，49，1： | 137 |
| 2 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 3 | 欧洲早产儿呼吸窘迫综合征防治共识指南(2013版)显示文摘本次指南更新包括了自2010年以来Cochrane系统评价和医学文献中的最新证据,并采纳了一种新的证据评估分级系统(GRADE)。以往关于早期肺表面活性物质和持续气道正压通气治疗的推荐目前拥有了更坚定的循证依据。对产房复苏、稳定生命体征等内容进行了较大扩充。生命体征稳定后的氧疗目前仍存在一定的争议,但是在获得更多的证据之前,血氧饱和度的目标范围不应低于90%,支持治疗对于超早早产儿仍然极为重要。指南对其他注意事项进行了缩减。 | Sweet D Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 王敏婕 袁琳 陈超 | 2014 | 中华儿科杂志2014，52，10： | 34 |
| 4 | 北京首钢工业区大气重金属污染树叶的磁学响应显示文摘在北京西郊首钢工业区及附近混杂的居民区、公园绿地和农村耕作区采集了55个一年生的树叶样品,并对其进行岩石磁学和元素含量分析.结果表明:磁性矿物的含量和粒径由污染源区向周边递减.研究区域树叶的磁性由低矫顽力的磁铁矿主导.进一步研究表明样品的主要磁性参数(磁化率、非磁滞剩磁以及饱和等温剩磁)与元素Fe,Pb,Cr,V和Zn呈显著相关关系(0.73≤R≤0.88).因此树叶的磁参数可以作为大气重金属污染研究的理想替代指标. | 胡守云 段雪梅 沈明洁 Blaha U Rosler W 闫海涛 Appel E Hoffmann V | 2008 | 科学通报2008，53，4： | 19 |
| 5 | 欧洲新生儿呼吸窘迫综合征防治共识显示文摘呼吸窘迫综合征(RDS)是由于肺表面活性物质(PS)缺乏及肺结构发育不成熟所致,多见于早产儿,自然病程为出生当时或生后很快发病,并在生后2d内进行性恶化,如不及时治疗,因进行性缺氧和呼吸衰竭而死亡。存活者出生后2—4d病情开始改善。RDS临床表现早期出现呼吸窘迫如紫绀、呻吟、吸凹和呼吸急促,然后进一步发展为呼吸衰竭,血气分析结果可提示呼吸衰竭的严重性。胸部X线典型的毛玻璃样改变和支气管充气征可以确诊。Vermont Oxford新生儿协作网对RDS的定义为: | Sweet D Bevilacqua G Carnielli V Greisen G Plavka R Didrik Saugstad O Simeoni U Speer CP Valls-I-Soler A Halliday H 袁琳(译) 陈超(译) 杜立中(校) | 2008 | 中华儿科杂志2008，46，1： | 17 |
| 6 | Magnetic response to atmospheric heavy metal pollution recorded by dust-loaded leaves in Shougang industrial area, western Beijing显示文摘Fifty-five evergreen tree's leaves growing less than one year were collected from Shougang industrial area in western suburb of Beijing, including steel plants and its ambient residential areas, recreational parks and farmlands. Rock magnetic properties and heavy metal contents were studied. The results show that the magnetic properties of leaf samples are predominated by low-coercivity magnetite, and both the concentration and grain size of magnetite particles gradually decreased with the distance from the main pollution source increases. Moreover, there is a significant linear relationship between magnetic parameters (the low-field magnetic susceptibility, saturation isothermal remanent magnetization and anhysteretic remanent magnetization) and heavy metals contents (Fe, Pb, V, Cr and Zn) (0.73≤R≤ 0.88). Hence, the magnetic parameters of leaves can serve as a proxy for quick detecting of the recent atmospheric metallic pollution. | HU ShouYun DUAN XueMei SHEN MingJie U BLAHA W ROESLER YAN HaiTao E APPEL V HOFFMANN | 2008 | Chinese Science Bulletin2008，53，10： | 10 |
| 7 | Peripheral blood lymphocytes DNA in patients with chronic liver diseases显示文摘BACKGROUND Viral replication in blood cells with nucleuses may lead to the damage of lymphocytes genetic apparatus and the beginning of immunopathological reactions.AIM Of this investigation is to reveal the damage to peripheral blood lymphocytes (PBL)DNA in the patients with chronic liver diseases.MATERIALS AND METHODS Sixteen-ninepatients with chronic liver diseases (37 patients with chronic viral hepatitis, 2 patients with liver cirrhosis of mixed etiology (alcohol + virus G),30 women with primary biliary cirrhosis-PBC)were examined. The condition of DNA structure of PBL-was measured by the fluorescenceanalysis of DNA unwinding (FADU) technique with modification. Changes of fluorescence (in %) reflected the DNA distractions degree (thepresence of DNA single-stranded breaks and alkalinelabile sights).RESULTS AND CONCLUSION . The quantity of DNA single-stranded breaks and alkalinelabile sightsin DNA in all patients with chronic viral hepatitis .didnt differ from the control group,excluding the patients with chronic hepatitis (CH) C + G. Patients with HGV and TTV monoinfection had demonstrated the increase of the DNA single-stranded breaks PBL quantity.This fact may be connected with hypothesisabout the viruses replication in white blood cells discussed in the literature. Tendency to increase quantity of DNA PBL damages in the patients with primary biliary cirrhosis (PBC) accordingly to the alkaline phosphatase activity increase was revealed. Significant decrease of the DNA single-stranded breaks and alkalinelabile sights in the PBC patients that were treated with prednison was demonstrated. Probably, the tendency to increase the quantity of DNA singlestranded breaks and alkalinelabile sights in lymphocytes of the PBC patients was depended on the surplus of the blood bile acid content. | Vasiliy I Reshetnyak Tatyana I Sharafanova Ludmila U Ilchenko Elena V Golovanova Gennadiy G Poroshenko | 2001 | World Journal of Gastroenterology2001，7，2： | 6 |
| 8 | 稻田CH_4排放及控制技术的研究(英文)显示文摘为了探索北方稻田水管理、施肥和水稻品种对稻田甲烷排放的影响 ,于 1995年至 1998年应用全自动甲烷采样 -测定系统 ,测定了水稻田甲烷排放通量。实验探明 :北方稻田甲烷排放通量为 4~364mg/m2 .d,平均值为 82 mg/m2 .d;稻田甲烷的季节排放只有一个高峰 ,发生在水稻分蘖期 ,该期的甲烷排放量占年排放总量的 85 %以上 ,水稻生长中、后期的稻田甲烷非常有限。水管理对稻田甲烷的生成、排放有显著的影响 ,稻田采用间歇灌溉代替常规灌溉和淹灌 ,可减排稻田甲烷 4 6%~ 5 9% ;稻田施用有机肥 ,甲烷排放量则剧增。但在同等有机碳含量情况下 ,不同有机肥的产甲烷潜势存在明显差异 ,猪粪和稻草较高 ,堆肥和牛粪较低 ,稻田施用堆肥和牛粪 ,可比施用猪粪和稻草的稻田减排稻田甲烷 72 %~ 90 % ;试验中选用的水稻品种 ,以中作 93的甲烷排放效率为最低 ,其甲烷排放通量比杂交稻京优和高秆品种中花 94 - 10 17减少 5 0 %~ 5 5 %。实验揭示 ,水稻分蘖期是控制北方稻田甲烷排放的关键时期 。 | 王增远 徐雨昌 李震 过益先 R Wassmann H U Neue R S Lantin L V Buendia | 2001 | 作物学报2001，27，6： | 5 |
| 9 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 10 | High glucose TGF-β1 regulates mesangial production of heparan sulfate proteoglycan显示文摘 | KOLM V SAUER U OLGEMOLIER B | 1996 | Am J Physial1996，270，52： | 2 |
| 11 | Celiac disease:diagnostic criteria in progress显示文摘Until a few years ago,celiac disease(CD)was thought to be a rare food intolerance that was confined to childhood and characterized by severe malabsorption and flat intestinal mucosa.Currently,CD is regarded as an autoimmune disorder that is common in the general population(affecting 1 in 100 individuals),with possible onset at any age and with many possible presentations.The identification of CD is challenging because it can begin not only with diarrhea and weight loss but also with atypical gastrointestinal(constipation and recurrent abdominal pain)and extra-intestinal symptoms(anemia,raised transaminases,osteoporosis,recurrent miscarriages,aphthous stomatitis and associated autoimmune disorders),or it could be completely symptomless.Over the last 20 years,the diagnostic accuracy of serology for CD has progressively increased with the development of highly reliable tests,such as the detection of IgA tissue transglutaminase and antiendomysial and IgG antideamidated gliadin peptide antibodies.The routine use of antibody markers has allowed researchers to discover a very high number of‘borderline’cases,characterized by positive serology and mild intestinal lesions or normal small intestine architecture,which can be classified as potential CD.Therefore,it is evident that the‘old celiac disease’with flat mucosa is only a part of the spectrum of CD.It is possible that serology could identify CD in its early stages,before the appearance of severe intestinal damage.In cases with a positive serology but with mild or absent intestinal lesions,the detection of HLA-DQ2 and HLA-DQ8 can help reinforce or exclude the diagnosis of gluten sensitivity. | U Volta V Villanacci | 2011 | Cellular & Molecular Immunology2011，8，2： | 2 |
| 12 | Development of Ag-clad Bi-2223 superconductors fpr electric power applications显示文摘 | Balachandran U Selvamanickam V Haldar P | 1998 | Supercond Sci Technol1998，11，： | 2 |
| 13 | Growth factors for fetal and adult human astrocytes in culture显示文摘 | Yong V W Kim S U Pleasure D E | 1998 | Brain Res1998，444，1： | 2 |
| 14 | Hemoglobin A1c in early postpartum screening of women with gestational diabetes显示文摘AIM:To assess the utility of hemoglobin A1c(HbA1c) in the early postpartum screening of women with gestational diabetes mellitus(GDM).METHODS:Over a 3 years period,HbA1c estimations were undertaken in addition to and simultaneously with the traditional oral glucose tolerance test(OGTT),in 203 women with GDM as a part of early postpartum screening for dysglycaemia,at 6 wk post-partum.World Health Organization criteria was used for diagnosing diabetes:fasting blood glucose(FBG) ≥ 7.0 mmol/Land/or 2-h postprandial blood glucose(PPBG) ≥ 11.1 mmol/L and/or HbA1c ≥ 48 mmol/mol;and impaired glycaemiastate:impaired fasting glucose 6.1-6.9 mmol/L and/or impaired glucose tolerance 7.8-11.0 mmol/L and/or HbA1c:42-47 mmol/mol.RESULTS:Mean FBG,2-h PPBG and HbA1c were 4.9 ± 0.7 mmol/L,5.6 ± 2.0 mmol/L and 38 ± 5 mmol/mol respectively.FBG,2-h PPBG and HbA1c detected 6(3%),7(3.5%) and 11(5.4%) cases of diabetes respectively,and 11(5.4%),25(12.3%) and 23(11.3%) cases of pre-diabetes state respectively.HbA1c values ≥ 48 mmol/mol(≥ 6.5%) showed a diagnostic sensitivity of 71.4% and specificity of 98.5% for diabetes in comparison to OGTT in receiver operating characteristics curve analysis.At HbA1c cut-off 44 mmol/mol,sensitivity and specificity were 100% and 92.3% respectively [area under the curve:0.98(95%CI:0.96-1.00)].Sensitivity and specificity for detecting high risk 'impaired glycaemia' state [HbA1c 42 mmol/mol(6.0%)] were 28% and 80%,respectively.CONCLUSION:HbA1c level ≥ 48 mmol/mol(≥ 6.5%) has reasonable sensitivity and high specificity in comparison to OGTT for early postpartum screening of diabetes in GDM.At 6 th week postpartum screening,if FBG is normal and HbA1c < 44 mmol/mol OGTT is not recommended. | Mahesh V Katreddy Joseph M Pappachan Sarah E Taylor Radha Indusekhar Ananth U Nayak Alan M Nevill | 2013 | World Journal of Diabetes2013，4，3： | 2 |
| 15 | Physiology and metabolic fluxes of wild-type and riboflavin-producing Bacillus subtilis显示文摘 | Sauser U Hatzimakikatis V Honmann H P | 1996 | Appl Envirnmental Miocrobiol1996，62，10： | 2 |
| 16 | Intravascular stents to prevent occlusion and restenosis after transluminal grafting显示文摘 | Sigwart U Puel J Mirkovitch V | 1986 | Radiology1986，160，： | 2 |
| 17 | Enantioselectivity of protoporphyrinogen oxidase-inhibiting herbicides 显示文摘 | Nandihalli U B Duke M V Ashmore J W | 1994 | Pestic Sci1994，40，： | 2 |
| 18 | Scattering of GPS Signals from the Ocean with Wind Remote Sensing Application显示文摘 | Zavorotny V U Voronovich A G | | 0，，02： | 2 |
| 19 | Wind Speed Measurement Using Forward Scattered GPS Signals显示文摘 | Garrison J L Komjathy A Zavorotny V U | | 0，，01： | 2 |
| 20 | 依据信息指标控制跳高运动员的专项身体训练的研究显示文摘优化控制运动训练要求借助于评价能反映运动技能水平的模式评定结果。研究目的:为了揭示反映不同技能水平的跳高运动员专项身体训练程度最具信息价值的指标。在纪念Ю·鲁科谢维奇的比赛前2年间进行研究。由跳高一级运动员和候补运动健将组成的第1组、由跳高运动健将和国际运动健将组成的第2组,共29名运动员参加测试,为了确定专项训练程度的水平,使用了能评定速度、力量、速度-力量能力、大腿和小腿肌群放松和紧张水平的肌张力测定仪,获取人体测量指标,分析运动员在从90 cm高度跳下'(跳深练习')后蹬跳张力的力量特点和时间特点。在下落后蹬地起跳'跳深练习'情况下获得的反映动作幅度特征(力量和速度)的结果,从而揭示不同训练程度水平的田径运动员上述指标变化的特点。 | В·С·勃科夫 Е·А·契列波夫 E·M·扬奇克 V·U·泽利晓夫 姚颂平(译) | 2017 | 首都体育学院学报2017，29，4： | 2 |
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