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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Impact of oil type on nanoemulsion formation and ostwald ripening stability 显示文摘 | TIM J W MATF G PEERASAK S | 2008 | Langmuir2008，24，12： | 1 |
| 3 | The coronary delivery of marrow stromal cells for myocardial regeneration: pathophysiologic and therapeutic implications 显示文摘 | Wang J S Shum Tim D Chedrawy E | 2001 | J Thorac Caridovasc Surg2001，122，4： | 1 |
| 4 | Biochar adsorbed ammonia is bioavailable显示文摘 | Rezoo T T Tim J C Robert R S | 2012 | Plant Soil2012，350，12： | 1 |
| 5 | The effect of bone morphogenetic protein-2 on rat in- tervertebral disc cells in vitro显示文摘 | Tim Yoon S Su Kim K Li J Soo Park J Akamaru T Elmer W A | 2003 | Spine(Phila Pa 1976)2003，28，： | 1 |
| 6 | A principled approach towards symbolic geometric constraint satisfaction显示文摘 | Bhansali S Kramer Glenn A Hoar Tim J | 1996 | Journal of Artificial Intelligence Research1996，4，： | 1 |
| 7 | The role of total hip replacement in the treatment of displaced intracapsular hip fractures in the elderly显示文摘 | Tim J Chesser S Vijaya M | 2012 | Inju- ry2012，43，10： | 1 |
| 8 | Market Influence on the Low Carbon Energy Refurbishment of Existing Multi - residential Buildings 显示文摘 | Jonathan G B A Tim J Elizabeth M S | 2009 | Energy Policy2009，，37： | 1 |
| 9 | The coronary delivery of marrow stromal cells for myoc ardial regeneration: pathophysiologic and therapeutic implication显示文摘 | Wang J S Shum Tim D Chedrawy E | 2001 | J Thorac Caridovasc Surg2001，122，： | 1 |
| 10 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 11 | Tests for nonlinearity in short stationary time series 显示文摘 | Taeun C Tim S Steven J S | 1995 | Chaos1995，5，1： | 1 |
| 12 | Bioanalytics and Biolabeling with Semiconductor Nanoparticles(Quantum Dots)显示文摘 | Lin C J Tim L Ralph A S | 2007 | Journal of Matery Chemistry2007，17，： | 1 |
| 13 | Atomic Force Micros- copy: Imaging with Electrical Double Layer Interactions 显示文摘 | TIM J S CALUM J D PATRICK K | 1994 | Langmuir1994，10，2： | 1 |
| 14 | Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells显示文摘 | Ivanov Andrei Beers Stephen A Walshe Claire A Honeychurch Jamie Alduaij Waleed Cox Kerry L Potter Kathleen N Murray Stephen Chan Claude H T Klymenko Tetyana Erenpreisa Jekaterina Glennie Martin J Illidge Tim M Cragg Mark S | 2009 | Journal of Clinical Investigation2009，，8： | 1 |
| 15 | Impact of oil type on nanoemulsion formation and Ostwald ripening stability显示文摘 | Tim J W Matt G Peerasak S | 2008 | Langmuir2008，24，12： | 1 |
| 16 | Compositional Factors Affecting NOx Emissions form Ohio Coals 显示文摘 | Kyung S J Tim C K Khang S | 2001 | Fuel Processing Technology2001，，74： | 1 |
| 17 | The coronary delivery of marrow stromal cells for myocardial regeneration:pathophysiologic and therapeutic implications 显示文摘 | Wang J S Shum Tim D Chedrawy E | 2001 | J Thorac Caridovasc Surg2001，122，4： | 1 |
| 18 | BiocharAdsorbed Ammonia Is Bioavailable显示文摘 | Arezoo T T Tim J C Robert R S | 2012 | Plant andSoil2012，350，2： | 1 |
| 19 | Oil sand deformation under cyclic loading of ultra-class mobile mining equipment显示文摘 | Ardeshir S D Tim G J | 2010 | Journal of Terramechanics2010，47，2： | 1 |
| 20 | Micro- bial factors rather than bioavailability limit the rate and extent of PAH biodegradation in aged crude oil contaminated model soils 显示文摘 | Huesemann Michael H Hausmann Tom S Fortman Tim J | 2002 | Bioremediation2002，6，4： | 1 |
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