|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Necrotizing enterocolitis: A multifactorial disease with no cure显示文摘Necrotizing enterocolitis is an inflammatory bowel disease of neonates with significant morbidity and mortality in preterm infants. Due to the multifactorial nature o the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm birth, hypoxic-ischemic events formula feeding, and abnormal bacteria colonization are established risk factors, the role of genetics and vasoactive/inflammatory mediators is unclear Consequently, treatments do not target the specific underlying disease processes and are symptomatic and surgically invasive. Breast-feeding is the most effective preventative measure. Recent advances in the prevention of necrotizing enterocolitis have focused on bioactive nutrients and trophic factors in human milk. Developmen of new disease models including the aspect of prematurity that consistently predisposes neonates to the disease with multiple risk factors will improve our understanding of the pathogenesis and lead to discovery of innovative therapeutics. | Kareena L Schnabl John E Van Aerde Alan BR Thomson Michael T Clandinin | 2008 | World Journal of Gastroenterology2008，14，14： | 19 |
| 2 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 3 | Nutritional modulation of the inflammatory response in inflammatory bowel disease-From the molecular to the integrative to the clinical显示文摘Nutrient deficiencies are common in patients with inflammatory bowel disease (IBD). Both total parenteral and enteral nutrition provide important supportive therapy for IBD patients, but in adults these are not useful for primary therapy. Dietary intervention with omega-3 polyunsaturated fatty acids contained in fish oil may be useful for the care of IBD patients, and recent studies have stressed the role of PPAR on NFκB activity on the potential beneficial effect of dietary lipids on intestinal function. | Gary E Wild Laurie Drozdowski Carmela Tartaglia M Tom Clandinin Alan BR Thomson | 2007 | World Journal of Gastroenterology2007，13，1： | 6 |
| 4 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 5 | Characterization and target identification of a DNA aptamer that labels pluripotent stem cells显示文摘 | Zhonggang Hou Susanne Meyer Nicholas E Propson jeff Nie Peng Jiang Ron Stewart James A Thomson | 2015 | Cell Research2015，25，3： | 5 |
| 6 | Occurrence and detection of AmpC β - lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates at a veterans medical center 显示文摘 | Coudron P E Moland E S Thomson K S | 2000 | J Clin Microbiol2000，38，： | 1 |
| 7 | Evaluation of a weather clutter simulation显示文摘 | Thomson A D Riseborough E S | 2001 | IEE Proceedings of Radar Sonar and Navigation2001，148，3： | 1 |
| 8 | Exact expressions for electric and magnetic fields from a propagating lightning channel with arbitrary orientation 显示文摘 | Thomson E M | 1999 | J Geophy Res1999，104，18： | 1 |
| 9 | Paroxysmal kinesigenic dyskinesia and generalized seizures:clinical and genetic analysis in a spanish pedigree显示文摘 | Cuenca-Leon E Cormand B Thomson T | 2002 | Neuropediatrics2002，33，6： | 1 |
| 10 | Manipulation of rumen fermentation in sheep by increasing the rate of flow of water from the rumen显示文摘 | Harrison D G Beever D E Thomson D J | 1975 | Journal of Agricultural Science1975，85，： | 1 |
| 11 | On the robust estimation of power spectra, coherences, and transfer functions显示文摘 | Chave A D Thomson D J Ander M E | 1987 | Journal of Geophysical Research1987，92，1： | 1 |
| 12 | A long-term population-based clinical and morbidity profile of Angelman syndrome in Western Australia:1953-2003显示文摘 | Thomson A K Glasson E J Bittles A H | | 0，，05： | 1 |
| 13 | A microRNA polycistron as a potential human oncogene显示文摘 | He L Thomson JM Hemann MT Hernando-Monge E Mu D Goodson S Powers S Cordon-Cardo C.Lowe SW Hannon GJ | | 0，，： | 1 |
| 14 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
| 15 | Infection with re- combinant Off viruses demonstrates that the viral interleukin-10 is a virulence factor 显示文摘 | Fleming S B Anderson I E Thomson J | 2007 | J Gen Virol2007，88，7： | 1 |
| 16 | Mechanical devices for pelvic organ prolapse in women显示文摘 | Adams E Thomson A Maher C | 2004 | Database Syst Rev2004，17，2： | 1 |
| 17 | Steric sea level trends in the northeast pacific ocean: possible evidence of global sea level rise显示文摘 | THOMSON R E TABATA S | 1989 | Jour- nal of Climate1989，2，6： | 1 |
| 18 | Cemento- blasts maintain expression of osteocalcin in the presence of mineral trioxide aggregate显示文摘 | Thomson T S Berry J E SomermanM J | 2003 | J Endod2003，29，6： | 1 |
| 19 | Protection of intestinal occludin tight junction protein by dietary gangliosides in lipopolysaccharide- induced acute in- flammation 显示文摘 | Park E J Thomson A B Clandinin M T | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，50，3： | 1 |
| 20 | Manipulation of rumen fermentation in sheep by in-creasing the rate of flow of water from the rumen 显示文摘 | HARRISON D G BEEVER D E THOMSON D J | 1975 | The Journal of Agricultural Science1975，85，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员