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| 1 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 2 | RosBREED:bridging the chasm between discovery and application to enable DNA-informed breeding in rosaceous crops显示文摘The Rosaceae crop family(including almond,apple,apricot,blackberry,peach,pear,plum,raspberry,rose,strawberry,sweet cherry,and sour cherry)provides vital contributions to human well-being and is economically significant across the U.S.In 2003,industry stakeholder initiatives prioritized the utilization of genomics,genetics,and breeding to develop new cultivars exhibiting both disease resistance and superior horticultural quality.However,rosaceous crop breeders lacked certain knowledge and tools to fully implement DNA-informed breeding—a“chasm”existed between existing genomics and genetic information and the application of this knowledge in breeding.The RosBREED project(“Ros”signifying a Rosaceae genomics,genetics,and breeding community initiative,and“BREED”,indicating the core focus on breeding programs),addressed this challenge through a comprehensive and coordinated 10-year effort funded by the USDA-NIFA Specialty Crop Research Initiative.RosBREED was designed to enable the routine application of modern genomics and genetics technologies in U.S.rosaceous crop breeding programs,thereby enhancing their efficiency and effectiveness in delivering cultivars with producer-required disease resistances and market-essential horticultural quality.This review presents a synopsis of the approach,deliverables,and impacts of RosBREED,highlighting synergistic global collaborations and future needs.Enabling technologies and tools developed are described,including genome-wide scanning platforms and DNA diagnostic tests.Examples of DNA-informed breeding use by project participants are presented for all breeding stages,including pre-breeding for disease resistance,parental and seedling selection,and elite selection advancement.The chasm is now bridged,accelerating rosaceous crop genetic improvement. | Amy F.Iezzoni Jim McFerson James Luby Ksenija Gasic Vance Whitaker Nahla Bassil Chengyan Yue Karina Gallardo Vicki McCracken Michael Coe Craig Hardner Jason D.Zurn Stan Hokanson Eric van de Weg Sook Jung Dorrie Main Cassia da Silva Linge Stijn Vanderzande Thomas M.Davis Lise L.Mahoney Chad Finn Cameron Peace | 2020 | Horticulture Research2020，7，1： | 2 |
| 3 | Global spread of dengue virus types: mapping the 70-year history显示文摘 | Jane P. Messina Oliver J. Brady Thomas W. Scott Chenting Zou David M. Pigott Kirsten Duda Samir Bhatt Leah Katzelnick Rosalind E. Howes Katherine E. Battle Cameron P. Simmons Simon I. Hay | 2013 | Trends in Microbiology2013，，： | 2 |
| 4 | US Multicenter Experience With the Wingspan Stent System for the Treatment of Intracranial Atheromatous Disease: Periprocedural Results显示文摘 | David Fiorella Elad I. Levy Aquilla S. Turk Felipe C. Albuquerque David B. Niemann Beverly Aagaard-Kienitz Ricardo A. Hanel Henry Woo Peter A. Rasmussen L Nelson Hopkins Thomas J. Masaryk Cameron G. McDougall | 2007 | Stroke2007，，3： | 1 |
| 5 | Extinetion risk from climate change 显示文摘 | Thomas CD Cameron A Green RE | 2004 | Nature2004，427，： | 1 |
| 6 | Extinction risk from climate change显示文摘 | Thomas C D Cameron A Green R E | 2004 | Nature2004，427，： | 1 |
| 7 | Extinction risk from climate change 显示文摘 | Thomas C D Cameron A Green R E | 2004 | Nature2004，，427： | 1 |
| 8 | WINGSPAN IN-STENT RESTENOSIS AND THROMBOSIS: INCIDENCE, CLINICAL PRESENTATION, AND MANAGEMENT显示文摘 | Elad I. Levy Aquilla S. Turk Felipe C. Albuquerque David B. Niemann Beverly Aagaard-Kienitz Lee Pride Phil Purdy Babu Welch Henry Woo Peter A. Rasmussen L. Nelson Hopkins Thomas J. Masaryk Cameron G. McDougall David J. Fiorella | 2007 | Neurosurgery2007，，3： | 1 |
| 9 | Extinction risk from climate change显示文摘 | Thomas C D Cameron A Green R E | 2004 | Nature2004，427，： | 1 |
| 10 | Associa- tion of folding intermediates of glycoproteins with cal- nexin during protein maturation显示文摘 | Ou W J Cameron P H Thomas D Y | 1993 | Nature1993，364，77： | 1 |
| 11 | Insect herbivory on C3 and C4 grasses显示文摘 | Thomas W Boutton Guy N Cameron Bruce N Smith | 1978 | Oecologia1978，36，1： | 1 |
| 12 | US Wingspan Registry: 12-Month Follow-Up Results显示文摘 | David J. Fiorella Aquilla S. Turk Elad I. Levy G. Lee Pride Henry H. Woo Felipe C. Albuquerque Babu G. Welch David B. Niemann Beverly Aagaard-Kienitz Peter A. Rasmussen L. Nelson Hopkins Thomas J. Masaryk Cameron G. McDougall | 2011 | Stroke2011，，7： | 1 |
| 13 | Extinction risk from climate change显示文摘 | Thomas D Cameron A Green G E | 2004 | Nature2004，427，： | 1 |
| 14 | Optimal Utilization of Donor Grafts With Extended Criteria: A Single-Center Experience in Over 1000 Liver Transplants显示文摘 | Andrew M. Cameron R Mark Ghobrial Hasan Yersiz Douglas G. Farmer Gerald S. Lipshutz Sherilyn A. Gordon Michael Zimmerman Johnny Hong Thomas E. Collins Jeffery Gornbein Farin Amersi Michael Weaver Carlos Cao Tony Chen Jonathan R. Hiatt Ronald W. Busuttil | 2006 | Annals of Surgery2006，，6： | 1 |
| 15 | Extinctionrisk from climate change显示文摘 | Thomas C D Cameron A Green R E | 2004 | Nature2004，427，6970： | 1 |
| 16 | Extinction risk from climate change 显示文摘 | THOMAS C D CAMERON A GREEN R E | 2004 | Nature2004，427，： | 1 |
| 17 | Extinction risk from climate change显示文摘 | Thomas C D Cameron A Green R E | 2004 | Nature2004，427，6970： | 1 |
| 18 | Extinction risk from cli- mate change 显示文摘 | Thomas C D Cameron A Green R E | 2004 | Nature2004，427，6970： | 1 |
| 19 | Extinction risk from climate change显示文摘 | Thomas C D Cameron A Green R E et a1 | 2004 | Nature2004，427，： | 1 |
| 20 | Extinction risk from cli-mate change显示文摘 | Thomas C D Cameron A Green R E | 2004 | Nature2004，427，： | 1 |
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