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| 1 | Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure显示文摘Acute hepatic failure due to hepatitis B virus(HBV)can occur both during primary infection as well as after reactivation of chronic infection.Guidelines recommend considering antiviral therapy in both situations,although evidence supporting this recommendation is weak.Since HBV is not directly cytopathic,the mechanism leading to fulminant hepatitis B is thought to be primarily immunemediated.Therefore,immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis B.Here wereport our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment,which resulted in a rapid improvement of clinical and liver parameters. | Jan-Hendrik Bockmann Maura Dandri Stefan Lüth Nadine Pannicke Ansgar W Lohse | 2015 | World Journal of Gastroenterology2015，21，7： | 13 |
| 2 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 3 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 4 | Premature p34cdc2 activation required for apoptosis显示文摘 | Shi L Nishioka W K Th'ng J | 1994 | Science1994，263，5150： | 1 |
| 5 | Friction and wear of carbon fibre filled polymer composites at room and low temperatures 显示文摘 | Theiler G Habner W Gradt Th | 2004 | Material Wissenschaft and Werkstoff Technik2004，35，1011： | 1 |
| 6 | IMP-4 and OXA beta-lacta-mases in Aeinetobaeter baumannii from Singapore显示文摘 | Koh TH Sng LH W ang GC | 2007 | J Antimi- crob Chemother2007，59，4： | 1 |
| 7 | Grinding of WC - Co hardmetals显示文摘 | HEGEMANJBJ W DE HOSSONJ Th M DE With G | 2001 | Wear2001，，248： | 1 |
| 8 | The African catfish,Clarias gariepinus,a model for the study of reproductive endocrinologyin teleosts显示文摘 | VAN OORDT P G W J GOOS H J Th | 1987 | Aquaculture1987，63，： | 1 |
| 9 | Growth-differentiation factor-15:a novel biomarker in patients with diastolic dysfunction?显示文摘 | Dinh W Füth R Lankisch M | 2011 | Arq Bras Cardiol2011，97，1： | 1 |
| 10 | Catastrophic debris flows on 13 August 2010 in the Qingping area, southwestern China: The combined effects of a strong earthquake and subsequent rainstorms显示文摘 | Tang C Van Asch Th W J Chang M | 2012 | Geomorphology2012，，： | 1 |
| 11 | Incomplete information about reciprocal incentives: an evolutionary approach to explaining cooperative behavior显示文摘 | Gu'th W | 1995 | International Journal of Game Theory1995，24，： | 1 |
| 12 | Validation of Fluoroscopy-Based Navigation in the Hip Region:What You See Is What You Get显示文摘 | Schep N W L VanWalsum Th Graaf J S | 2002 | Computer Aided Surgery2002，7，： | 1 |
| 13 | Surface generation in electrochemical machining显示文摘 | Konig W Aachen/D(1)TH | 1978 | Annals of the CIRP1978，27，： | 1 |
| 14 | Effect of NADPH oxidase in- hibition on endothelial cell ELAM-1 mRNA expression 显示文摘 | Suzuki Y Wang W Vu TH | 1992 | Biochem Biophys Res Commun1992，184，3： | 1 |
| 15 | The regulation of gonadotropin release by neurohormones and gonadal steroids in the African catfish, Clarias gariepinus 显示文摘 | De Leeuw R Goos H J Th Van Oordt P G W J | 1987 | Aquaculture1987，63，14： | 1 |
| 16 | Water flow and solute transport process in the unsaturated zone显示文摘 | Nielsen D R Van Genuchten M Th Biggar J W | 1986 | Water Resources Research1986，22，9： | 1 |
| 17 | PI state space cur- rent control of grid-connected PWM converters with LCL filters 显示文摘 | DANNEHL J FUCHS F W TH X F | 2010 | IEEE Transactions on Power Electronics2010，25，9： | 1 |
| 18 | The per- formance of human dental pulp stem cells on different three-di- mensional scaffold materials 显示文摘 | Zhang W Walboomers XF van Kuppevelt TH | 2006 | Biomat2006，27，33： | 1 |
| 19 | Update on scar management: guidelines for treating Asian patients 显示文摘 | Kim S Choi TH Liu W | 2013 | Plast Reconstr Surg2013，132，6： | 1 |
| 20 | Biological denitrification in microbial fuel cells 显示文摘 | Clauwaert P Rabaey K Aelterman P Schamphelaire LD Pham TH Boeckx P Boon N Verstraete W | 2007 | Environ Sci Teehnol2007，41，9： | 1 |
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