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| 1 | Elevated uric acid in- crease the risk for kidney disease显示文摘 | Obermayr RP Temml C Gutjabr G | 2008 | J Am Soc Nephrol2008，19，12： | 1 |
| 2 | Serum androgen levels in men:impact of health status and age显示文摘 | Schatzl G Maderbacher S Temml C | 2003 | Urology2003，61，3： | 1 |
| 3 | Elevated uric acid increases the risk for kidney disease显示文摘 | Obemayr RP Temml C Gutjahr G | 2008 | J Am Soc Nephrol2008，19，12： | 1 |
| 4 | The association between vascular risk factors and lower urinary tract symptoms in both sexes显示文摘 | Ponholzer A Temml C Wehrberger C | 2006 | Eur Urol2006，50，3： | 1 |
| 5 | Elevated Uric AcidIncreases the Risk for Kidney Disease 显示文摘 | Rudolf P Obermayr Christian Temml | 2008 | J Am Soc Nephrol2008，19，： | 1 |
| 6 | Urinary inconti- nence in both sexes: Prevalence rates and impact on quality of life and sexual life 显示文摘 | Temml C Haidinger G Schmidbauer J | 2000 | Neurourol Urodyn2000，19，3： | 1 |
| 7 | Prevalence and correlates for interstitial cystitis symptoms in women participating in a health screening project 显示文摘 | Temml C Wehrberger C Riedl C | 2007 | European Urology2007，51，： | 1 |
| 8 | Elevated uric acid Increa- ses the risk for kidney disease 显示文摘 | Obermayr R P Temml C Gutjahr G | 2008 | J Am Soc Nephrol2008，19，12： | 1 |
| 9 | Urinary incontinence in both sexes:prevalence rates and impact on quality of life and sexual life显示文摘 | Temml C Haidinger G Schmidbauer J | 2000 | Neurourol Urodyn2000，19，3： | 1 |
| 10 | Elevated uric acid increa- ses the risk for kidney disease显示文摘 | Obermayr RP Temml C Gutjahr G | 2008 | Am Soc Nephrol2008，19，12： | 1 |
| 11 | Elevated u- ric acid increases the risk for kidney disease显示文摘 | Obermayr RP Temml C Gutjahr G | 2008 | J Am Soc Nephrol2008，19，12： | 1 |
| 12 | Prevalence of the overactive bladder syndrome by applying the International Continence Society definition显示文摘 | Heidler S Ponhoizer A et el | 2005 | Eur Urol2005，48，4： | 1 |
| 13 | Are lower urinary tract symptoms influenced by metabolic syndrome?显示文摘 | TEMML C OBERMAYR R MARSZALEK M | 2009 | Urology2009，73，3： | 1 |
| 14 | From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution显示文摘Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction.Lipid mediators orchestrate both the initiation and resolution of inflammation.Switching from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation,though drug candidates exhibiting such features are unknown.Starting from a library of Vietnamese medical plant extracts,we identified isomers of the biflavanoid 8-methylsocotrin-4’-ol from Dracaena cambodiana,which limit inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile from leukotrienes to specialized pro-resolving mediators(SPM).Elucidation of the absolute configurations of 8-methylsocotrin-4’-ol revealed the 2 S,γSisomer being most active,and molecular docking studies suggest that the compound binds to an allosteric site between the 5-lipoxygenase subdomains.We identified additional subordinate targets within lipid mediator biosynthesis,including microsomal prostaglandin E2 synthase-1.Leukotriene production is efficiently suppressed in activated human neutrophils,macrophages,and blood,while the induction of SPM biosynthesis is restricted to M2 macrophages.The shift from leukotrienes to SPM was also evident in mouse peritonitis in vivo and accompanied by a substantial decrease in immune cell infiltration.In summary,we disclose a promising drug candidate that combines potent 5-lipoxygenase inhibition with the favorable reprogramming of lipid mediator profiles. | Tran Thi Van Anh Alilou Mostafa Zhigang Rao Simona Pace Stefan Schwaiger Christian Kretzer Veronika Temml Carsten Giesel Paul M.Jordan Rossella Bilancia Christina Weinigel Silke Rummler Birgit Waltenberger Tran Hung Antonietta Rossi Hermann Stuppner Oliver Werz Andreas Koeberle | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 1 |
| 15 | Is erectile dysfunction an indicator for increased risk of coronary heart disease and stroke?显示文摘 | Ponholzer A Temml C Obermayr R | 2005 | Eur Urol2005，48，3： | 1 |
| 16 | Prevalence and correlates for interstitial cystitis symptoms in women participating in a health screening project显示文摘 | Temml C Wehrberger C Riedl C | 2007 | Eur Urol2007，51，3： | 1 |
| 17 | Elevated uric acid increases the risk for kidney disease显示文摘 | Obermayr RP Temml C Gutjahr G Knechtelsdorfer M Oberbauer R Klanser-Braun R | 2008 | J Am Soc Nephrol2008，19，12： | 1 |
| 18 | Predictors of new-onset decline in kidney function in a general middle-European population显示文摘 | Obermayr RP Temml C Knechtelsdorfer M Gutjahr G Kletsmayr J Heiss S | 2008 | Nephrol Dial Transplant2008，23，4： | 1 |
| 19 | Cross - sectional study of noeturia in both sexes: analysis of a voluntary health screening project 显示文摘 | Sehatzl G Temml C Sehmidbauer J | 2000 | Urology2000，56，： | 1 |
| 20 | Elevated uric acid increases the risk for kidney disease显示文摘 | Obermayr RP Temml C Gutjahr G | 2008 | J Am Soc Nephrol2008，19，： | 1 |
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