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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 2 | The role of fine particle lactose on the dispersion and deaggregation of salbutamol sulphate in an air stream in vitro 显示文摘 | ZENG X M MARTIN G P TEE S K | 1998 | Int J Pharm1998，176，1： | 1 |
| 3 | Chaotic Behavior in Erbium-doped Fiber Ring Lasers显示文摘 | Luo L G Tee T J Chu P L | 1998 | J Opt Soc Am B1998，15，3： | 1 |
| 4 | Anchoring skeletal muscledevelopment and disease:the role of ankyrin repeat domiancontaining proteins in muscle physiology显示文摘 | TEE J M PEPPELENBOSCH M P | 2010 | Critical Reviews inBiochemistry and Molecular Biology2010，45，4： | 1 |
| 5 | Genetic polymor phism of urokinase type plasminogen activator is interacting with plasminogen activator inhibito>1 to raise risk of cervical neoplasia显示文摘 | Tee Y T Wang P H Tsai H T | 2012 | J Surg Oncol2012，106，2： | 1 |
| 6 | The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites 显示文摘 | HERBERT T P TEE A R PROUD C G | 2002 | J Biol Chem2002，277，11： | 1 |
| 7 | Chironomidae haemoglobins: their detection and role in allergy to midges in the Sudan and elsewhere 显示文摘 | Cranston P S Tee R D Credland P F Kay A B | 1983 | Memoirs of American Entomological Society1983，34，： | 1 |
| 8 | Barrier Lyapunov Func- tions for the control of output-constrained nonlinear systems显示文摘 | Tee K P Ge S S Tay E H | 2009 | Automatica2009，45，4： | 1 |
| 9 | Advances in lung cancer diagnosis and staging: endobronchial ultrasound 显示文摘 | Koh M S Tee A Wong P | 2008 | Intern Med J2008，38，2： | 1 |
| 10 | Tuberous sclerosis complex gene products,Tuberin and Hamartin,control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb显示文摘 | MANNING B D ROUX P P | 2003 | Curr Biol2003，13，15： | 1 |
| 11 | Clinical and molecular genetic features of ARC syndrome显示文摘 | Gissen P Tee L Johnson CA | | 0，，： | 1 |
| 12 | Approximation-based control of uncertain helicopter dynamics 显示文摘 | Ge S S Ren B Tee K P | 2009 | IET Control Theory and Applications2009，3，7： | 1 |
| 13 | Regu- lation of targets of mTOR ( mammalian target of rapa- mycin) signalling by intracellular amino acid availa- bility 显示文摘 | BEUGNET A TEE A R TAYLOR P M | 2003 | Biochemical Journal2003，372，： | 1 |
| 14 | Chaotic behavior in erbium-doped fiber-ring lasers显示文摘 | Luo L G Tee T J Chu P L | 1998 | Opt Soc Am B1998，15，3： | 1 |
| 15 | Evaluation of matrix metalloproteinase 2 expression in cervical carcinogenesis using tissue array and integrated optical density for immunoreactivity显示文摘 | Tee Y T Han C P Ko J L et a! | 2007 | Reprod Sci2007，14，3： | 1 |
| 16 | Clinical and molecular genetic features of ARC syndrome显示文摘 | Gissen P Tee L Johnson CA | | 0，，03： | 1 |
| 17 | Approximation-based control of nonlinear MIMO time-delay systems显示文摘 | Ge S S Tee K P | 2007 | Automatica2007，43，1： | 1 |
| 18 | Stability and motor adaptation in human arm movements显示文摘 | BURDET E TEE K P KAWARTO M | 2006 | Biological Cybernetics2006，94，： | 1 |
| 19 | Approximation-based control of nonlinear mimo time-delay systems 显示文摘 | GE S S TEE K P | 2007 | Automatica2007，43，1： | 1 |
| 20 | Barrier Lyapunov Functions for the control of output-constrained nonlinear systems显示文摘 | Tee K P Ge S S Tay E H | 2009 | Automatica2009，45，4： | 1 |
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