|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review显示文摘AIM: To investigate roles of genetic polymorphisms in non-alcoholic fatty liver disease(NAFLD) onset, severity, and outcome through systematic literature review. METHODS: The authors conducted both systematic and specific searches of Pub Med through December 2015 with special emphasis on more recent data(from 2012 onward) while still drawing from more historical data for background. We identified several specific genetic polymorphisms that have been most researched and, at this time, appear to have the greatest clinical significance on NAFLD and similar hepatic diseases. These were further investigated to assess their specific effects on disease onset and progression and the mechanisms by which these effects occur. RESULTS: We focus particularly on genetic polymorphisms of the following genes: PNPLA3, particularly the p. I148 M variant, TM6SF2, particularly the p. E167 K variant, and on variants in FTO, LIPA, IFNλ4, and iron metabolism, specifically focusing on HFE, and HMOX-1. We discuss the effect of these genetic variations and their resultant protein variants on the onset of fatty liver disease and its severity, including the effect on likelihood of progression to cirrhosis and hepatocellular carcinoma. While our principal focus is on NAFLD, we also discuss briefly effects of some of the variants on development and severity of other hepatic diseases, including hepatitis C and alcoholic liver disease. These results are briefly discussed in terms of clinical application and future potential for personalized medicine. CONCLUSION: Polymorphisms and genetic factors of several genes contribute to NAFLD and its end results. These genes hold keys to future improvements in diagnosis and management. | Tyler J Severson Siddesh Besur Herbert L Bonkovsky | 2016 | World Journal of Gastroenterology2016，22，29： | 12 |
| 2 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 3 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 4 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 5 | Initial management of acute bacterial meningitis in adults:summary of IDSA guidelines显示文摘 | Beckham J D Tyler K L | 2006 | Rev Neurol Dis2006，3，2： | 1 |
| 6 | Management strategies to decrease calf death losses in beef herds显示文摘 | LARSON R L TYLER J W SCHULTZ L G | 2004 | J Am Vet Med Assoc2004，224，1： | 1 |
| 7 | 医疗卫生保健文化的反思及促进健康与文化融合的建议显示文摘1医疗卫生保健文化的反思1.1健康文化与医学知识如果医务人员有充足的时间对患者进行诊断并帮助患者进行社区护理,就可在节省卫生费用的同时改善健康结果。整合型社区护理能缩小不同文化背景和群体健康需求的差异。然而,全球范围内对整合型社区护理的投入较少,原因之一就是20世纪对临床服务的重视弱化了卫生服务提供过程中的同情心理。当然,患者也对医学知识存在显性和隐性的影响(特别是当其因不遵医嘱而受到指责时)。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson JWoolf K | 2016 | 中国卫生政策研究2016，9，4： | 1 |
| 8 | Reovirusinduced apoptosis requires mitochondrial release of Smac/DIABLO and involves reduction of cellular inhibitor of apoptosis protein levels显示文摘 | Kominsky D J Bixkel R J Tyler K L | 2002 | J Virol2002，76，11： | 1 |
| 9 | Removal of Cytokine Inducing Substances by Polymyxin - B Immobilized Polystyrene - derivative Fibers during In Vitro Hemoperfusion of 10% Human Plasma Containing Staphylococcus aureus Challenge 显示文摘 | Bertrand L J Tyler W B Miguel C N | 1998 | A SAD J1998，48，： | 1 |
| 10 | Della proteins and gib- berellin-regulated seed germination and floral development in Arabidopsis 显示文摘 | Tyler L Thomas S G Hu J | 2004 | Plant Physiol2004，135，： | 1 |
| 11 | Pneumocystis carinii pneumonia in foals 显示文摘 | Cowell R L Tyler R D | 1994 | J Am Vet Med Asso1994，204，： | 1 |
| 12 | Difficulties experienced by tinnitus sufferers显示文摘 | TYLER R S BAKER L J | 1983 | J Speech Hear Disord1983，48，： | 1 |
| 13 | Cryptosporidiosis in people: it's not just about the cows 显示文摘 | CHAKO C Z TYLER J W SCHULTZ L G | 2010 | J Vet Intern Med2010，24，1： | 1 |
| 14 | Trends in Wheat-Flour Fortification with Folic Acid and Iron - Worldwide, 2004 and 2007显示文摘 | Maberly G Grummer-Strawn L Jefferds M E Pe?a-Rosas J P Serdula M K Tyler V Q Berry R J Mulinare J Parvanta I Aburto N J | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，1： | 1 |
| 15 | Organizational Impression Management: Utilizing Anticip'atory Tactics 显示文摘 | Tyler M J Connaughton L S | 2012 | Basic and Applied Social Psychology2012，，34： | 1 |
| 16 | No evidence of sleep apnea in children with attention deficit hyperactivity disorder 显示文摘 | Cooper J Tyler L Wallace I | 2004 | Clin Pediatr2004，43，： | 1 |
| 17 | Steric effects of the t-butyl group in organosilicon compounds显示文摘 | Sommer L H Tyler L J | 1953 | J Am Chem Soc1953，，76： | 1 |
| 18 | A Three-Wave FDTD Approach to Surface Scattering with Applications to Remote Sensing of Geophysical Surfaces显示文摘 | WONG P B TYLER G L BARON J E | | 0，，04： | 1 |
| 19 | DELLA proteins and gibberellin-regulated seed germination and floral development in Arabidopsis显示文摘 | Tyler L Thomas S G Hu J | 2004 | Plant Physiology2004，135，： | 1 |
| 20 | DELLA Proteins and Gibberellin-regulated Seed Germination and Floral Development in Arabidopsis 显示文摘 | TYLER L THOMAS S G HU J | 2004 | Plant Physiol2004，135，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员