|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 2 | Overexpression of PGA37/MYB118 and MYB115 promotes vegetative-to-embryonic transition in Arabidopsis显示文摘从 non-germline 房间的体的胚胎的形成对更高的植物唯一并且能被操作在许多种类。以前的研究表明包括 WUSCHEL (WUS )/PLANT 生长 ACTIVATOR6 (PGA6 ) ,几 Arabidopsis 基因的 overexpression 纵容繁荣,叶状的 COTYLEDON1 (LEC1 ) ,和 LEC2,能引起 vegetative-to-embryonic 转变或体的胚胎的形成。这里,我们报导那在 Arabidopsis PGA37 基因的一个 gain-of-function 变化,编码 MYB118 抄写因素,导致的 vegetative-to-embryonic 转变,从根将生物的活组织移植于培养基中培养的体的胚胎的形成,和提高的 LEC1 表示水平。两倍变异的分析证明 WUS 没被 PGA37/MYB118 为体的胚胎的正式就职要求。另外, MYB115 的 overexpression, PGA37/MYB118 的一个相当或相同的事物,引起了象 pga37 一样显型。两倍异种没显示出的 myb118 myb115 明显的发展畸形。一起,这些结果建议 PGA37/MYB118 和 MYB115 支持 vegetative-to-embryonic 转变,通过 WUS 的一个发信号的小径独立人士。 | Xingchun wang Qi-Wen Niu Chong Teng Chao Li Jinye Mu Nam-Hai Chua Jianru Zuo | 2009 | Cell Research2009，19，2： | 30 |
| 3 | New prospecting progress using information and big data of coal and oil exploration holes on sandstone-type uranium deposit in North China显示文摘1.Objective A series of Mesozoic-Cenozoic continental sedimentary basins exist in North China,coexisting with coal,oil/gas,and salt resources.Many previous drilling projects have been conducted within these basins to explore coal,petroleum,and mineral resources,however,these data have not been integrated due to different industries owners.In order to efficiently explore the large-sized,easily extracted,and environmentally friendly,sandstone-type uranium deposits,previous coal and oil exploration drilling-hole data are systematically collected, processed,and analyzed to improve the sandstone-type uranium prospecting exploitation.At the same time,we also discussed the uranium source,ore-forming process and model for the sandstone-type uranium deposits. | Ruo-shi Jin Pei-sen Miao Xian-zhang Sima Reng-An Yu Yin-hang Cheng Chao Tang Tian-fu Zhang Cong Ao Xue-ming Teng | 2018 | China Geology2018，1，1： | 12 |
| 4 | Macrophage Inhibitory Cytokine-1 as a Novel Diagnostic and Prognostic Biomarker in Stage I and II Nonsmall Cell Lung Cancer显示文摘 | Yu-Ning Liu Xiao-Bing Wang Teng Wang Chao Zhang Kun-Peng Zhang Xiu-Yi Zhi Wei Zhang Ke-Lin Sun | 2016 | Chinese Medical Journal2016，，17： | 12 |
| 5 | Ultra-small MoS2 nanodots with rapid body clearance for photothermal cancer therapy显示文摘因为这些 nanomaterials 的长期的保留,许多无机的 nanomaterials 的临床的翻译被毒性问题严重地在身体妨碍。在这研究,我们基于极端小的瞬间 2 nanodots 开发了一个 bio-clearable theranostic 代理人,它被一条灵巧的自底向上的途径通过铵 tetrathiomolybdate 的一步舞 solvothermal 分解综合。在由谷胱甘肽(GSH ) 的修正以后,没有聚集,获得的瞬间 2-GSH nanodots 在各种各样的生理的缓冲区展出了 sub-10-nm 水动力学直径。没有出现在 vitro 毒性可估计,如此的瞬间 2-GSH nanodots 与强壮在红外线附近(NIR ) 吸收度能导致癌症房间的显著 photothermal 脱离。在之上静脉内(i.v ) 注射,瞬间 2-GSH nanodots 的有效肿瘤累积被 photoacoustic 成像观察,并且进一步由瞬间的 biodistribution 的分析证实了。尤其是,与有更大的尺寸的常规瞬间 2 nanoflakes 相对照,瞬间 2-GSH nanodots 经由尿显示出有效身体清理,在注射剂量的多数在就七天以内被清除的地方。老鼠上的肿瘤的 Photothermal 脱离然后与瞬间 2-GSH nanodots 被认识到,完成优秀治疗学的功效。这研究与有效肿瘤 homing/treatment 能力,以及快速的身体清理行为介绍极端小的 nanoparticle 的一种新类型,为没有长期的毒性担心的癌症 theranostics 使它有希望。 | Teng Liu Yu Chao Min Gao Chao Liang Qian Chen Guosheng Song Liang Cheng Zhuang Liu | 2016 | Nano Research2016，9，10： | 10 |
| 6 | Crack monitoring method based on Cu coating sensor and electrical potential technique for metal structure显示文摘Advanced crack monitoring technique is the cornerstone of aircraft structural health monitoring.To achieve real-time crack monitoring of aircraft metal structures in the course of service,a new crack monitoring method is proposed based on Cu coating sensor and electrical potential difference principle.Firstly,insulation treatment process was used to prepare a dielectric layer on structural substrate,such as an anodizing layer on 2A12-T4 aluminum alloy substrate,and then a Cu coating crack monitoring sensor was deposited on the structure fatigue critical parts by pulsed bias arc ion plating technology.Secondly,the damage consistency of the Cu coating sensor and2A12-T4 aluminum alloy substrate was investigated by static tensile experiment and fatigue test.The results show that strain values of the coating sensor and the 2A12-T4 aluminum alloy substrate measured by strain gauges are highly coincident in static tensile experiment and the sensor has excellent fatigue damage consistency with the substrate.Thirdly,the fatigue performance discrepancy between samples with the coating sensor and original samples was investigated.The result shows that there is no obvious negative influence on the fatigue performance of the 2A12-T4 aluminum alloy after preparing the Cu coating sensor on its surface.Finally,crack monitoring experiment was carried out with the Cu coating sensor.The experimental results indicate that the sensor is sensitive to crack,and crack origination and propagation can be monitored effectively through analyzing the change of electrical potential values of the coating sensor. | Hou Bo He Yuting Cui Ronghong Gao Chao Zhang Teng | 2015 | Chinese Journal of Aeronautics2015，28，3： | 10 |
| 7 | Catalytic ozonation treatment of papermaking wastewater by Ag-doped NiFe2O4 : Performance and mechanism显示文摘The catalytic ozonation treatment of secondary biochemical effluent for papermaking wastewater by Ag-doped nickel ferrite was investigated.Ag-doped catalysts prepared by sol-gel method were characterized,illustrating that Ag entirely entered the crystalline of Ni Fe2O4 and changed the surface properties.The addition of catalyst enhanced the removal efficiency of chemical oxygen demand and total organic carbon.The results of gas chromatography-mass spectrometer,ultraviolet light absorbance at 254 nm and threedimensional fluorescence excitation-emission matrix suggested that aromatic compounds were efficiently degraded and toxic substances,such as dibutyl phthalate.In addition,the radical scavenging experiments confirmed the hydroxyl radicals acted as the main reactive oxygen species and the surface properties of catalysts played an important role in the reaction.Overall,this work validated potential applications of Ag-doped Ni Fe2O4 catalyzed ozonation process of biologically recalcitrant wastewater. | Junyu Zhao Jiashun Cao Yujie Zhao Teng Zhang Di Zheng Chao Li | 2020 | Journal of Environmental Sciences2020，32，11： | 7 |
| 8 | lncRNA NEAT1 promotes the Taxol resistance of breast cancer via sponging the miR-23a-3p-FOXA1 axis显示文摘Breast cancer is the most prevalent malignancy among women worldwide.Paclitaxel(Taxol)is a widely applied chemotherapeutic agent against breast cancer.Although Taxol therapy has achieved improvements recently,development of chemoresistance of breast cancer patients is a major obstacle,leading to therapeutic failure.Long non-coding RNAs(lncRNAs)play pivotal roles in tumorigenesis and progresses of breast cancer.However,the biological roles and molecular targets of lncRNA NEAT1 in Taxol-resistant breast cancer remain unclear.Here,we report that NEAT1 is significantly upregulated in breast tumors and cell lines.In addition,silencing NEAT1 effectively sensitizes breast cancer cells to Taxol.Bioinformatical analysis and luciferase assay demonstrated that miR-23a-3p could be sponged and downregulated by NEAT1.We demonstrated that miR-23a-3p was downregulated and functioned as a tumor suppressor in breast cancer.Furthermore,in the established Taxol-resistant MDA-MB-231 breast cancer cell line,we detected significantly increased NEAT1 expression and downregulated miR-23a-3p expression.Importantly,FOXA1 was identified and validated as a direct target of miR-23a-3p in breast cancer cells.Rescue experiments demonstrated that the restoration of miR-23a-3p in NEAT1-overexpressing Taxol-resistant breast cancer cells successfully overcame the NEAT1-promoted Taxol resistance.Taken together,our results revealed the clinical roles and molecular mechanisms for the NEAT1-mediated chemoresistance,providing new insights into the development of non-coding RNA-based therapeutic strategies for enhancing the anti-cancer effects of traditional chemotherapeutic drugs. | Lin Zhu Fengchun Wang Wenhui Fan Zhi Jin Chao Teng Jianxin Zhang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 7 |
| 9 | Rh-incompatible hemolytic disease of the newborn in Hefei显示文摘BACKGROUND Anti-D antibody is not the common cause of Rh-isoimmunization in Chinese neonatal jaundice.Recent change in national population policy has followed by an increase in Rh-isoimmunization related hemolytic disease of the newborn(HDN).Unfortunately,regional status of Rh-HDN is unavailable.We hypothesize that Rh-HDN in our region is most commonly due to anti-E antibody.AIM To investigate the prevalence of hemolytic disease of the newborn due to Rhisoimmunization in Hefei City.METHODS Retrospective review of data obtained from Children’s Hospital of Anhui and Hefei Blood Center between January 2017 and June 2019.Status of minor blood group antibody was studied in the corresponding mothers.RESULTS Totally 4138 newborns with HDN admitted during the study period and 116(2.8%)received blood exchange transfusion(BET).Eighteen newborns(0.43%)with proven Rh-incompatible HDN were identified.All were not the first-born baby.Thirteen mothers were RhD(+)(72%)and five were RhD(-).The distribution of Rh-related antibodies in mothers was ten anti-E(55%),five anti-D(27%),and for one anti-C,anti-c,and anti-E/c(6%)each.Thirteen(72.2%)were qualified for BET,relative risk for BET was 28.9 as compared to other types of HDN,but only 10 received due to parenteral refusal.All(100%)RhD related HDN received BET which is not significantly different from RhE related HDN(81.8%).CONCLUSION As expected,all Rh-incompatible HDN newborns were not the first-born.Contrary to the Caucasian population,anti-D induced HDN is not the most common etiology.In our region,anti-E(11/18,61%)is the most common cause of Rh-HDN. | Shao-Hua Bi Liang-Liang Jiang Li-Ying Dai Hong Zheng Jian Zhang Li-Li Wang Chao Wang Qiao Jiang Yu Liu Yong-Li Zhang Juan Wang Chao Zhu Guang-Hui Liu Ru-Jeng Teng | 2019 | World Journal of Clinical Cases2019，7，20： | 7 |
| 10 | Estrogen and insulin synergistically promote endometrial cancer progression via crosstalk between their receptor signaling pathways显示文摘Objective: Despite evidence that estrogens and insulin are involved in the development and progression of many cancers, their synergistic role in endometrial carcinoma(EC) has not been analyzed yet.Methods: Here, we investigated how estrogens act synergistically with insulin to promote EC progression. Cell growth in vitro and in vivo, effects of estradiol and insulin on apoptosis and cell cycle distribution, and expression and activation of estrogen receptor(ER), insulin receptor(InsR), and key proteins in the PI3K and MAPK pathways were examined after combined stimulation with estradiol and insulin.Results: Compared to EC cells treated with estradiol or insulin alone, those treated with both estradiol and insulin exhibited stronger stimulation. Estradiol significantly induced phosphorylation of InsR-β and IRS-1, whereas insulin significantly induced phosphorylation of ER-α. In addition, treatment with both insulin and estradiol together significantly increased the expression and phosphorylation of Akt, MAPK, and ERK. Notably, InsR-β inhibition had a limited effect on estradiol-dependent proliferation,cell cycle, and apoptosis, whereas ER-α inhibition had a limited insulin-dependent effect, in EC cell lines. Insulin and estradiol individually and synergistically promoted EC xenograft growth in mice.Conclusions: Estrogen and insulin play synergistic roles in EC carcinogenesis and progression by activating InsR-β and ER-α,promoting a crosstalk between them, and thereby resulting in the activation of downstream PI3K/Akt and MAPK/ERK signaling pathways. | Wenyan Tian Fei Teng Jinping Gao Chao Gao Guoyan Liu Yanfang Zhang Shizhu Yu Wei Zhang Yingmei Wang Fengxia Xue | 2019 | Cancer Biology & Medicine2019，16，1： | 6 |
| 11 | Computer-aided ionic liquid design for alkane/cycloalkane extractive distillation process显示文摘A computer-aided ionic liquid design(CAILD) study is presented for the frequently encountered alkane/cycloalkane separations in petrochemical industry. Exhaustive experimental data are first collected to extend the UNIFAC-IL model for this system, where the proximity effect in alkanes and cycloalkanes is considered specifically by defining distinct groups. The thermodynamic performances of a large number of ILs for 4 different alkane/cycloalkane systems are then compared to select a representative example of such separations. By applying n-heptane/methylcyclohexane extractive distillation as a case study, the CAILD task is cast as a mixed-integer nonlinear programming(MINLP) problem based on the obtained task-specific UNIFAC-IL model and two semi-empirical models for IL physical properties. The top 5 IL candidates determined by solving the MINLP problem are subsequently introduced into Aspen Plus for process simulation and economic analysis, which finally identify 1-hexadecyl-methylpiperidinium tricyanomethane([C_(16)MPip][C(CN)_3]) as the best entrainer for this separation. | Zhen Song Xinxin Li He Chao Fan Mo Teng Zhou Hongye Cheng Lifang Chen Zhiwen Qi | 2019 | Green Energy & Environment2019，4，2： | 6 |
| 12 | Granular porous calcium carbonate particles for scalable and high-performance solar-driven thermochemical heat storage显示文摘Calcium carbonate is promising thermochemical heat storage material for next-generation solar power systems due to its high energy storage density,low cost,and high operation temperature.Researchers have tried to improve energy storage performances of calcium carbonate recently,but most researches focus on powders,which are not suitable for scalable applications.Here,novel granular porous calcium carbonate particles with very high solar absorptance,energy storage density,abrasive resistances,and energy storage rate are proposed for direct solar thermochemical heat storage.The average solar absorptance is improved by 234%compared with ordinary particles.Both cycle stability and abrasive resistances are excellent with almost no decay of energy storage density over 25 cycles nor apparent particle weight loss over 24 h of continuous operation insides a planetary ball mill.In addition,the decomposition temperature is reduced by 2.8%–5.6%while the reaction rate of heat storage is enhanced by 80%–205%depending on the CO_(2) partial pressure.The decomposition process of doped granular porous CaCO_(3) particles is found to involve three overlapping processes.This work provides new routes to achieve scalable direct solar thermochemical heat storage for next-generation high-temperature solar power systems. | SONG Chao LIU XiangLei XUAN YiMin ZHENG HangBin GAO Ke TENG Liang DA Yun LI Chuan LI YongLiang DING YuLong | 2021 | Science China(Technological Sciences)2021，64，10： | 4 |
| 13 | Principal component analysis and belief-rule-base aided health monitoring method for running gears of high-speed train显示文摘Dear editor,We propose a data-driven health monitoring method for running gears of a high-speed train.In the proposed approach,the principal component analysis(PCA)method is used to perform feature extraction while the belief-rule-base(BRB)method is used to perform health monitoring tasks.To improve the monitoring performance. | Chao CHENG Xinyu QIAO Wanxiu TENG Mingliang GAO Bangcheng ZHANG Xiaojing YIN Hao LUO | 2020 | Science China(Information Sciences)2020，63，9： | 4 |
| 14 | Single-Step Organization of Plasmonic Gold Metamaterials with Self-Assembled DNA Nanostructures显示文摘Self-assembled DNA nanostructures hold great promise as nanoscale templates for organizing nanoparticles(NPs)with nearatomistic resolution.However,large-scale organization of NPs with high yield is highly desirable for nanoelectronics and nanophotonic applications.Here,we design fve-strand DNA tiles that can readily self-assemble into well-organized micrometerscale DNA nanostructures.By organizing gold nanoparticles(AuNPs)on these self-assembled DNA nanostructures,we realize the fabrication of one-and two-dimensional Au nanostructures in single steps.We further demonstrate the one-pot synthesis of Au metamaterials for highly amplifed surface-enhanced Raman Scattering(SERS).Tis single-step and high-yield strategy thus holds great potential for fabricating plasmonic metamaterials. | Shaokang Ren Jun Wang Chunyuan Song Qian Li Yanjun Yang Nan Teng Shao Su Dan Zhu Wei Huang Jie Chao Lianhui Wang Chunhai Fan | 2019 | Research2019，，1： | 4 |
| 15 | Sonodynamic therapy with immune modulatable two-dimensional coordination nanosheets for enhanced anti-tumor immunotherapy显示文摘Ultrasound with deep penetration depth and high security could be adopted in sonodynamic therapy(SDT)by activating sonosensitizers to generate cytotoxic reactive oxygen species(ROS).Herein,two-dimensional(2D)coordination nanosheets composed of Zn^(2+)and Tetrakis(4-carboxyphenyl)porphyrin(TCPP)are fabricated.While exhibiting greatly enhanced ultrasoundtriggered ROS generation useful for noninvasive SDT,such Zn-TCPP 2D nanosheets show high loading capacity of oligodeoxynudeotides such as cytosine—phosphorothioate-guanine(CpG),which is a potent toll like receptor 9(TLR9)agonist useful in activating immune responses.Highly effective SD T of primary tumors could release tumor-associated antigens,which working together with Zn-TCPP/CpG adjuvant nanosheets could function like whole-tumor-cell vaccines and trigger tumor-specific immune responses.Interestingly,ultrasound itself could strengthen anti-tumor immune responses by improving the tumor-infiltration of T cells and limiting regulatory T cells in the tumor microenvironment.Thus,SDT using Zn-TCPP/CpG nanosheets after destruction of primary tumors could induce potent antitumor immune responses to inhibit distant abscopal tumors without direct SD T treatment.Moreover,SDT with Zn-TCPP/CpG could trigger strong immunological memory effects to inhibit cancer recurrence after elimination of primary tumors.Therefore,the 2D coordination nanosheet may be a promising platform to deliver potent SDT-triggered immunotherapy for highly effective cancer treatment. | Wenjun Zhu Qian Chen Qiutong Jin Yu Chao Lele Sun Xiao Han Jun Xu Longlong Tian Jinglei Zhang Teng Liu Zhuang Liu | 2021 | Nano Research2021，14，1： | 3 |
| 16 | An accurate SISAR imaging method of ground moving target in forward scatter radar显示文摘In order to accurately extract the profile image of the ground moving targets(GMT) in the forward scatter radar(FSR),a forward scatter signal model of GMT is built based on the Fresnel-Kirchhoff diffraction formula,the multipath propagation model and the high order phase approximation method.The classical shadow inverse synthetic aperture radar(SISAR) imaging algorithm is modified using the proposed signal model.In the modified imaging algorithm,the impacts of ground reflection,non-linear variation of target Doppler frequency and the target motion direction on imaging accuracy are discussed.Meanwhile,non-linear and time-dependent parameters are used to compensate for the motion phase of the GMT forward scatter signal,and a novel estimation method of the height difference and median line height of the target profile is put forward under the multipath interference.Finally,both the accuracy of the proposed signal model and the effectiveness of the modified imaging algorithm are validated by the simulation results. | HU Cheng LI XiaoLiang LONG Teng ZHOU Chao | 2012 | Science China(Information Sciences)2012，55，10： | 3 |
| 17 | SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice显示文摘Establishment of the primordial follicle(PF)pool is pivotal for the female reproductive lifespan;however,the mechanism of primordial folliculogenesis is poorly understood.Here,the transcription factor SP1 was shown to be essential for PF formation in mice.Our results showed that SP1 is present in both oocytes and somatic cells during PF formation in the ovary.Knockdown of Sp1 expression,especially in pregranulosa cells,significantly suppressed nest breakdown,oocyte apoptosis,and PF formation,suggesting that SP1 expressed by somatic cells functions in the process of primordial folliculogenesis.We further demonstrated that SP1 governs the recruitment and maintenance of Forkhead box L2-positive(FOXL2^+)pregranulosa cells using an Lgr5-EGFP-IRES-CreER^T2(Lgr5-KI)reporter mouse model and a FOXL2^+ cell-specific knockdown model.At the molecular level,SP1 functioned mainly through manipulation of NOTCH2 expression by binding directly to the promoter of the Notch2 gene.Finally,consistent with the critical role of granulosa cells in follicle survival in vitro,massive loss of oocytes in SP1 knockdown ovaries was evidenced before puberty after the ovaries were tranSP1anted under the renal capsules.Conclusively,our results reveal that SP1 controls the establishment of the ovarian reserve by regulating pregranulosa cell development in the mammalian ovary. | Han Cai Bingying Liu Huarong Wang Guanghong Sun Lizhao Feng Ziqi Chen Jiaqi Zhou Jiawei Zhang Tuo Zhang Meina He Tingting Yang Qirui Guo Zhen Teng Qiliang Xin Bo Zhou Hua Zhang Guoliang Xia Chao Wang | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 18 | High prevalence of occult hepatitis B virus infection in patients with B cell non-Hodgkin’s lymphoma显示文摘 | Ming-Huang Chen Liang-Tsai Hsiao Tzeon-Jye Chiou Jin-Hwang Liu Jyh-Pyng Gau Hao-Wei Teng Wei-Shu Wang Ta-Chung Chao Chueh-chuan Yen Po-Min Chen | 2008 | Annals of Hematology2008，，6： | 2 |
| 19 | Moisture transfer and phase change in unsaturated soils: an experimental study of two types of canopy effect显示文摘Canopy effect refers to the phenomenon in which moisture accumulates underneath an impervious cover.A canopy effect can lead to full saturation of the soil underneath the impervious cover.A recent theoretical study separates the canopy effect into two types.The first one is caused by evaporation-condensation in unsaturated soils,while the second one is induced by freezing-enhanced vapour transfer in unsaturated soils.To validate experimentally these two types of canopy effect and to reveal their mechanisms,moisture-migration experiments were carried out,using a newly developed laboratory apparatus for unsaturated frozen soils.Six conditions were applied to the calcareous sand,with different initial water contents and boundary temperatures.The results show that water content in the upper portion of the sample increased under an upward temperature gradient,and the increment of water content was greater if the soil was subjected to freezing.For the freezing cases,the depth of the peak water content was in line with the freezing front.And the greater the initial water content,the more the water content accumulated at the freezing front.However,a lower cooling rate seemed to facilitate vapour migration.For the unfrozen cases,the water content in the upper portion of the sample also increased;and the increases became more apparent with a higher initial moisture content.The temperature gradient can also inhibit the vapour migration.A less steep temperature gradient always resulted in a more notable inhibition effect.Test results seem to verify the theory of the canopy effect. | Zuo Yue He Ji Dong Teng Sheng Zhang Dai Chao Sheng | 2017 | Research in Cold and Arid Regions2017，9，3： | 2 |
| 20 | Associations between serum uric acid and hepatobiliary-pancreatic cancer:A cohort study显示文摘BACKGROUND Uric acid is the end product of purine metabolism.Previous studies have found that serum uric acid(SUA)levels are associated with the total cancer risk.However,due to the dual effect of uric acid on cancer,the relationship between the SUA levels and most specific-site cancer remains unclear.AIM To investigate the associations between the SUA levels and incidence of hepatobiliary-pancreatic cancer.METHODS In this prospective cohort study,444462 participants free of cancer from the UK Biobank were included.The SUA levels were measured at baseline,and the incidence of hepatobiliary-pancreatic cancer was determined by contacting the cancer registry.The hazard ratios(HRs)and 95%confidence intervals(CIs)between the SUA levels and hepatobiliary-pancreatic cancer were investigated using multiple adjusted Cox regression models adjusted for potential confounders.RESULTS In total,920 participants developed liver,gallbladder,biliary tract or pancreatic cancer during a median of 6.6 yrs of follow-up.We found that the HR of pancreatic cancer in the highest SUA group was 1.77(95%CI:1.29-2.42)compared with that in the lowest group.After stratifying by gender,we further found that SUA was associated with an increased risk of pancreatic cancer only among the females(highest quartile vs lowest quartile HR 2.04,95%CI:1.35-3.08).Among the males,the SUA levels were positively associated with the gallbladder cancer risk(highest quartile vs lowest quartile HR 3.09,95%CI:1.28-7.46),but a U-shaped association with the liver cancer risk was observed(P-nonlinear=0.03).CONCLUSION SUA is likely to have gender-specific effects on hepatobiliary-pancreatic cancer.High SUA levels are a risk factor for pancreatic cancer in females and gallbladder cancer in males.A U-shaped association with the liver cancer risk was identified. | Chong-Fei Huang Jun-Jun Huang Ning-Ning Mi Yan-Yan Lin Qiang-Sheng He Ya-Wen Lu Ping Yue Bing Bai Jin-Duo Zhang Chao Zhang Teng Cai Wen-Kang Fu Long Gao Xun Li Jin-Qiu Yuan Wen-Bo Meng | 2020 | World Journal of Gastroenterology2020，26，44： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员