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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 3 | The COA360: A Tool for Assessing the Cultural Competency of Healtheare Organizations 显示文摘 | LaVeist TA Relosa R Sawaya N | 2008 | J Healthc Manag2008，53，4： | 1 |
| 4 | Hyperoxia mediates acute lung injury and increased lethality in murine Legionella pneumonia: the role of apoptosis显示文摘 | Tateda K Deng JC Moore TA Newstead MW Paine R 3rd Kobayashi N | 2003 | J Immunol2003，170，8： | 1 |
| 5 | Analysis of risk factors-especially different types of plexitis-for postoperative relapse in Crohn's disease显示文摘AIM To evaluate the presence of submucosal and myenteric plexitis and its role in predicting postoperative recurrence.METHODS Data from all patients who underwent Crohn's disease(CD)-related resection at the University of Szeged, Hungary between 2004 and 2014 were analyzed retrospectively. Demographic data, smoking habits, previous resection, treatment before and after surgery, resection margins, neural fiber hyperplasia, submucosal and myenteric plexitis were evaluated as possible predictors of postoperative recurrence. Histological samples were analyzed blinded to the postoperative outcome and the clinical history of the patient. Plexitis was evaluated based on the appearance of the most severely inflamed ganglion or nerve bundle. Patients underwent regular follow-up with colonoscopy after surgery. Postoperativerecurrence was defined on the basis of endoscopic and clinical findings, and/or the need for additional surgical resection. RESULTS One hundred and four patients were enrolled in the study. Ileocecal, colonic, and small bowel resection were performed in 73.1%, 22.1% and 4.8% of the cases, respectively. Mean disease duration at the time of surgery was 6.25 years. Twenty-six patients underwent previous CD-related surgery. Forty-three point two percent of the patients were on 5-aminosalicylate, 20% on corticosteroid, 68.3% on immunomodulant, and 4% on anti-tumor necrosis factor-alpha postoperative treatment. Postoperative recurrence occurred in 61.5% of the patients; of them 39.1% had surgical recurrence. 92.2% of the recurrences developed within the first five years after the index surgery. Mean disease duration for endoscopic relapse was 2.19 years. The severity of submucosal plexitis was a predictor of the need for second surgery(OR = 1.267, 95%CI: 1.000-1.606, P = 0.050). Female gender(OR = 2.21, 95%CI: 0.98-5.00, P = 0.056), stricturing disease behavior(OR = 3.584, 95%CI: 1.344-9.559, P = 0.011), and isolated ileal localization(OR = 2.671, 95%CI: 1.033-6.910, P = 0.043) were also predictors of postoperative recurrence. No association was revealed between postoperative recurrence and smoking status, postoperative prophylactic treatment and the presence of myenteric plexitis and relapse.CONCLUSION The presence of severe submucosal plexitis with lymphocytes in the proximal resection margin is more likely to result in postoperative relapse in CD. | Agnes Milassin Anita Sejben László Tiszlavicz Zita Reisz Gyorgy Lázár Mónika Szucs Renáta Bor Anita Bálint Mariann Rutka Zoltán Szepes Ferenc Nagy Klaudia Farkas Tamás Molnár | 2017 | World Journal of Gastrointestinal Surgery2017，9，7： | 1 |
| 6 | T i t a n i u m -w a t e r l oop h ea t p i p e o p e r a t i n gc h a r a c t e r i s t i c s u n d e r s t a n d a r d a nd e l e v a t e da ccel er at ion f i e l d s 显示文摘 | A J F l e m i n g S K T h o m a s k L Y e r k e s e ta l | 2010 | Journal of T h e r m o p h y s i c sand Heat T r a n s f e r2010，24，1： | 1 |
| 7 | R e a s o n s lo r a n d d e v e lo p m e n ts in in te rn a tio n a ls c ie n tific c o lla b o ra tio n : d o e s a n A s ia - P a c ific r e se a rc h a r e a e x is t Iro m a b ib lio m e tric p o in t o l v iew显示文摘 | H A U S T E IN S T U N G E R D H E IN R IC H S G e ta l | 2011 | S c ie n to m e tr ic s2011，86，3： | 1 |
| 8 | Outcome mea r u rement:Show i ngresults in the nonprof it sector显示文摘 | P l a n t z M C Ta y l o r G r e e n w a y M Hend r ick s M | 1997 | New directionsfor Evaluation1997，，75： | 1 |
| 9 | A highly efficient Cu/LaZ03 catalyst for transfer dehydrogenation of primaryaliphatic alcohols显示文摘 | Shi R Wang F Ta N | 2010 | Green Chem2010，120，： | 1 |
| 10 | A vaccine that prevents pregnance in woman显示文摘 | Ta|war G P Om sing I3 R Chatter jee P N | 1994 | P Natl Acad Sci USA1994，91，18： | 1 |
| 11 | The algorithmic analysis of hybrid systems显示文摘 | Alur R Courcoubetis C Halbwachs N Henzinger TA Ho PH Nicollin X Olivero A Sifakis J Yovine S | | 0，，01： | 1 |
| 12 | V e r t e b r a l f r a c t u r e s i n p a t i e n t s w i t hankylosing spondylitis:a retrospective analysis of66 patients显示文摘 | A l t e n b e r n d J B i t u S L e m b u r g S e ta 1 | 2009 | Rofo2009，，18： | 1 |
| 13 | P u b l i c a t io n , c o o p e ra tio n a n d p ro d u c tiv itym e a s u r e s in s c ie n tific r e s e a r c h 显示文摘 | G A U F F R IA U M L A R S E N P 0 M A Y E I e ta l | 2007 | S c ie n to m e tri c s2007，73，2： | 1 |
| 14 | The transmembrane CXC-chemokine ligand 16 is induced by IFN-and TNF-and shed by the activity of the disintegrin-like metalloproteinase ADAM10显示文摘 | Abel S Hundhausen C Mentlein R Schulte A Berkhout TA Broadway N | 2004 | J Immunol2004，172，： | 1 |
| 15 | M ethodologyfor vertical-navigation flight-trajectory cost calculationusing a perform ance d atabase显示文摘 | M U R R IE TA M E N D O ZA A B O TEZ R M | 2015 | Journal ofA erospace Inform ation System s2015，12，51： | 1 |
| 16 | E v a l u a t i n g H e a l t h I m p a c t Assessment显示文摘 | Q u i g l e y R o b e r t J Ta y l o r L o r r a i n e C | 2004 | Journal of the Royal Institute of Public Health2004，118，： | 1 |
| 17 | Adiponectin actions in the cardiovascular system显示文摘 | Hopkins TA Ouchi N Shibata R | | 0，，： | 1 |
| 18 | Comparison of retroperitoneoscopic nephrectomy with open surgery for tuberculous nonfunctioning kidneys显示文摘 | HemalA K Gup ta N P Kumar R | 2000 | J Urol2000，164，1： | 1 |
| 19 | T h e P r o m is e o fEntrepreneurship as A Field o f Research 显示文摘 | S h a n e S V e n k a ta r a m a n S | 2000 | Academy o fManagement R ev iew2000，25，1： | 1 |
| 20 | Improvement of N-glycan site occupancy of therapeutic glycoproteins produced in Pichia pastoris显示文摘 | Choi B-K Warburton S Lin H Patel R Boldogh I Meehl M d'Anjou M Pon L Stadheim TA Sethuraman N | | 0，，03： | 1 |
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