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| 1 | Role of bile acid sequestrants in the treatment of type 2 diabetes显示文摘Cholestyramine is a first-generation bile acid sequestrant(BAS) and antihyperlipidemic agent that currentl y has limited use because of its relatively weak effect on lowering low density-lipoprotein(LDL)-chol es terol(C) and poor tolerability.The current first choice drugs for hyper-LDL-cholesterolemia are 3-hy droxy-3-me t hyl-glutaryl coenzyme A reductase inhibitors(statins) because of their strong LDL-C lowering effects and efficacy in prevention of card io vascular disease.Howe ver,after lowering the target levels of LDL-C in very high risk patients,combination therapy with statins and other antihyper lipidemic drugs may become more important for treatment of hyper-LDL-cholesterolemia.Second-generation BASs such as coles evelam and colestimide have a glucose-lowering effect and improved tolerance,which has led to re-evaluation of their utility in combination with statins or antidiabetic agents. | Kohzo Takebayashi Yoshimasa Aso Toshihiko Inukai | 2010 | World Journal of Diabetes2010，1，5： | 4 |
| 2 | Effect of proton pump inhibitors on glycemic control in patients with diabetes显示文摘Gastrin is a linear peptide hormone which is secreted mostly in the stomach pyloric antrum G cells. Although the main role of this hormone is the promotion of the secretion of gastric acid from the stomach parietal cells, gastrin can also behave as a growth factor and stimulate gastric cell proliferation. It is also reported that gastrin promotes β cell neogenesis in the pancreatic ductal complex, modest pancreatic β cell replication, and improvement of glucose tolerance in animal models, in which the remodeling of pancreatic tissues is promoted. These findings suggest the possibility that gastrin has the potential to promote an increase of β cell mass in pancreas, and therefore that gastrin may improve glucose tolerance. Proton pump inhibitors(PPIs) are wildly used clinically for the therapy of gastro-esophageal reflex disease, gastritis due to excess stomach acid, and gastric ulcers. PPIs indirectly elevate serum gastrin levels via a negative feedback effect. Recent evidence has revealed the beneficial effect of PPIs on glycemic control especially in patients with type 2 diabetes mellitus(T2DM), probably via the elevation of the levels of serum gastrin, although the detailed mechanism remains unclear. In addition, the beneficial effects of a combination therapy of gastrin or a PPI with a glucagon-like peptide-1 receptor agonist on glycemic control in animal models have been demonstrated. Although PPIs may be possible candidates for a new approach in the therapy of diabetes, a prospective, longterm, randomized, double-blind, placebo-controlled study is needed to establish the effect of PPIs on glycemic control in a large number of patients with T2 DM. | Kohzo Takebayashi Toshihiko Inukai | 2015 | World Journal of Diabetes2015，6，10： | 2 |
| 3 | Clinicopathological and prognostic significance of thymidine phosphorylase and proliferating cell nuclear antigen in gastric carcinoma 显示文摘 | Konno S Takebayashi Y Aiba M | 2001 | Cancer Lett2001，166，1： | 1 |
| 4 | Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-120 cells显示文摘 | Sumizawa T Takebayashi Y | 1999 | J Natl Cancer Inst1999，91，19： | 1 |
| 5 | Thymidine phosphorylase in human esophageal squamous cell carcinoma 显示文摘 | Takebayashi Y Natsugoe S Baba M | 1999 | Cancer1999，85，2： | 1 |
| 6 | Ecteinascidin743 induces protein linked DNA breaks in human colon carci noma HCT 116 cells and is cytotoxic independently of topoi somerase I expression显示文摘 | Takebayashi Y Goldwasser F Urasaki Y et aL | 2001 | ClinCancer Res2001，7，1： | 1 |
| 7 | Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma显示文摘 | MINETA H MIURA K TAKEBAYASHI S | 2003 | Oral Oncol2003，39，1： | 1 |
| 8 | Aldosterone blockadc attenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicated by diabetic nephropathy显示文摘 | Takebayashi K Matsumoto S Aso Y | 2006 | J Clin Endocrinol Metab2006，91，6： | 1 |
| 9 | Thymidine phosphorylase in human esophageal squamous cell car cinoma显示文摘 | TAKEBAYASHI Y NATSUGOE S BABA M | 1999 | Cancer1999，85，2： | 1 |
| 10 | Poisoning of human DNA topoisomerase Ⅰ by ecteinascidin 743, an anti cancer drug that selectively aikyl, ates DNA in the minor groove显示文摘 | Takebayashi Y Pourquier P Yoshida A | 1999 | Proc Natl Acad Sci USA1999，96，13： | 1 |
| 11 | Expression of beta--catenin in developing auditory epithelia of mice显示文摘 | Takebayashi S Nakagawa T Kojima K | 2004 | Acta Otolaryngol2004，，： | 1 |
| 12 | Conversion of ectoderm into a neural fate by ATH-3, a verte- brate basic helix-loophelix gene homologous to Drosophlia proneural gene atonal显示文摘 | Takebayashi K Takahashi S Yokota C | 1997 | EMBO J1997，16，： | 1 |
| 13 | Decreased levels of whole blood glial cell line-derived neurotrophic factor (GDNF) in remitted patients with mood disorders显示文摘 | Takebayashi M Hisaoka K Nishida A | 2006 | Int J Neuropsychopharmacol2006，9，： | 1 |
| 14 | Significance of adventitial inflammation of coronary artery in patients with unstable angina:results at autopsy显示文摘 | Kohchi K Takebayashi S Hiroki T | 1985 | Circulation1985，71，4： | 1 |
| 15 | Diagnosis of the nutcracker syndroj with color Doppler sonography:correlation with flow paaems on retrograde left renal venography显示文摘 | Takebayashi S Ueki T Ikeda N | 1999 | AJR1999，172，： | 1 |
| 16 | Dependence of biodegradation and release behavior on physical proper- ties of poly ( caprolactone ) - based polyurethanes显示文摘 | Watanabe A Takebayashi Y Ohtsubo T | 2009 | Journal of Applied Polymer Science2009，114，1： | 1 |
| 17 | Aldosterone blockake attenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicatded by diabetic nephropathy显示文摘 | Takebayashi K Matsumoto S Aso Y | 2006 | J Clin Endocrinol Metab2006，91，6： | 1 |
| 18 | Using helical CT to evaluate renal cell carcinoma in patients undergoing hemodialysis:Value of early enhanced images显示文摘 | Hidai H Chiba T | 1999 | AJR1999，172，2： | 1 |
| 19 | Thymidine phosphorylase expression in gastric carcinoma as a marker for metastasis显示文摘 | Konno S Takebayashi Y Higashimoto M | 2003 | Anticancer Res2003，23，6： | 1 |
| 20 | Expression of the ad renomedullin gene in epithelial ovarian cancer显示文摘 | Hata K Takebayashi Y Akiba S | 2000 | Mol Hum Re- prod2000，6，10： | 1 |
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