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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Liver transplantation for adult polycystic liver disease 显示文摘 | Swenson K Seu P Kinkhabwala M | 1998 | Hepatology1998，28，： | 1 |
| 3 | Vitamin D status and bone and connective tissue turnover in brown bears (Ursus arctos) during hibernation and the active state显示文摘 | Vestergaard P St?en OG Swenson JE | | 0，，06： | 1 |
| 4 | Vitamin D status and bone and connective tissue turnover in brown bears (Ursusarctos)during hibernation and the active state显示文摘 | Vestergaard P Stoen OG Swenson JE | 2011 | PLoS One2011，，21： | 1 |
| 5 | Synthesis and Structures of Mono-and Bis(amidinate)Complexes of Aluminum显示文摘 | Coles M P Swenson D C Jordan R F | 1997 | Organometallics1997，16，： | 1 |
| 6 | A study to evaluatesafety and efficacy of mepolizumab in patients with moderate per- sistent asthma显示文摘 | Flood-Page P Swenson C Faiferman I | 2007 | Am J Respir Crit Care Med2007，176，： | 1 |
| 7 | Liposome technology and the development of Myocet TM ( liposomal doxoru- bicin citrate) 显示文摘 | SWENSON CE PERKINS WR ROBERT P | 2001 | Breast2001，2，2： | 1 |
| 8 | A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma显示文摘 | Flood-Page P Swenson C Faiferman I | 2007 | Am J Respir Crit Care Med2007，176，： | 1 |
| 9 | Zinc and copper status in ewes supplemented with sulfate-and amino acid-complexed forms of zinc and copper显示文摘 | Hatfield P G Swenson C K Kott R W Ansotegui R P Roth N J Robinson B L | 2001 | Journal of Animal Science2001，79，1： | 1 |
| 10 | Hypoxic ventilato- ry response, ventilation, gas exchange, and fluid balance in acute mountain sickness显示文摘 | Bartsch P Swenson ER Paul A | 2002 | High Alt Med Biol2002，3，： | 1 |
| 11 | Extension of saphenous thrombus into the femoral vein:a potential complication of new endovenous ablation techniques显示文摘 | Mozes G Kalra M Carmo M Swenson L Gloviczki P | 2005 | J Vasc Surg2005，41，： | 1 |
| 12 | Hypoxic ventila tory response, ventilation, gas exchange, and fluid balance in a cute mountain sickness显示文摘 | BARTSCH P SWENSON E R PAUL A | 2002 | High Alt Med Biol2002，3，4： | 1 |
| 13 | Zinc and copper status in ewes supplemented with sulfate-and amino acid-complexed forms of zinc and copper显示文摘 | Hatfield P G Swenson C K and R W Kott | 2001 | Journal of Animal Science2001，，79： | 1 |
| 14 | In Vitro and In Vivo Antifungal Activity of Amphotericin B Lipid Complex: Are Phospholipases Important? 显示文摘 | Swenson CE Perkins WR Roberts P | 1998 | Antimicrob Agents Chemother1998，42，4： | 1 |
| 15 | Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload 显示文摘 | Hu P Zhang D Swenson L | 2003 | Am J Physiol Heart Circ Physiol2003，285，3： | 1 |
| 16 | Thyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms 显示文摘 | Bejarano P A Nikiforov Y E Swenson E S | 2000 | Appl immunohistoehem Mol Morphol2000，8，3： | 1 |
| 17 | ICF ignition capsule neutron, gamma ray, and high energy x-ray images显示文摘 | Bradley P A Wilson D C Swenson F J | 2003 | Rev Sci In- strum2003，74，3： | 1 |
| 18 | A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma 显示文摘 | Flood-Page P Swenson C Faiferman I | 2007 | Am J Respir Crit Care Med2007，176，11： | 1 |
| 19 | Thymidylate synthase inhibitors 显示文摘 | MALLIH SWENSON S | 1999 | Semin Oncol1999，26，6： | 1 |
| 20 | Climate Model Biases in Seasonality of Continental Water Storage Revealed by Satellite Gravimetry 显示文摘 | Swenson S C Milly P | 2006 | Water Resources Research2006，42，： | 1 |
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