|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Estrogen enhances the functions of CD4^(+)CD25^(+)Foxp3^(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro显示文摘Cross-talk has been shown to occur between the immune system and bone metabolism pathways.In the present study,we investigated the impact of CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells on osteoclastogenesis and bone resorption.Treg cells that were isolated and purified from peripheral blood mononuclear cells(PBMCs)of healthy adults inhibited both the differentiation of osteoclasts(OCs)from human embryo bone marrow cells(BMCs)and the pit formation in a dose-dependent manner.In cell cocultures,the production levels of both interleukin-10(IL-10)and transforming growth factor-beta 1(TGF-β1)were proportionally upregulated as the ratio of Treg cells to BMCs was increased,and the inhibition of OC differentiation and bone resorption by Treg cells was completely reversed by anti-IL-10 and anti-TGF-β1 antibodies.Treatment of BMC and Treg cell cocultures with 17β-estradiol(E2)at concentrations between 10^(-7) and 10^(-9) mol/l suppressed OC differentiation and bone resorption more efficiently than it did in cultures of BMCs alone;this enhanced suppression occurred via the stimulation of Treg cell IL-10 and TGF-b1 expression.These data suggest that Treg cells suppress OC differentiation and bone resorption by secreting IL-10 and TGF-β1.E2 enhances the suppressive effects of Treg cells on OC differentiation and bone resorption by stimulating IL-10 and TGF-β1 secretion from these cells.Therefore,Treg cell-derived IL-10 and TGF-b1 are likely involved in the regulation of E2 on bone metabolism and represent potential therapeutic targets for the treatment of postmenopausal osteoporosis(PMO). | CY Luo L Wang C Sun DJ Li | 2011 | Cellular & Molecular Immunology2011，8，1： | 33 |
| 2 | 急性缺血性脑卒中后低脉压与不良预后相关显示文摘众所周知,脉压与心脏功能、动脉僵硬度、体液状态和血管事件有关。该研究旨在探讨基于中国台湾地区脑卒中登记资料的急性缺血性脑卒中(acute ischemic stroke,AIS)患者入院时脉压的预后作用。 | 刘莉 叶鹏 Tang SC Yin JH Liu CH Sun MH Lee JT Sun Y Hsu CS Sun MC Lin CH Chen CH Lien LM Muo CH Jeng JS Hsu CY | 2017 | 中华高血压杂志2017，25，7： | 5 |
| 3 | Determination of dioxopromethazine hydrochloride by capillary electrophoresis with electrochemiluminescence detection显示文摘 | Li YH Wang CY Sun JY | 2005 | Analytica Chimica Acta2005，550，12： | 1 |
| 4 | Early gestational intrauterine infection induces postnatal lung inflammation and arrests lung development in a rat model 显示文摘 | Zhan CY Yuan TM Sun Y | 2011 | J Matern Fetal Neonatal Meal2011，24，2： | 1 |
| 5 | The inflammatory modulation effect of glutamine-enriched total parenteral nutrition in postoperative gastrointestinal cancer patients显示文摘 | Lu CY Shih YL Sun LC | 2011 | Am Surg2011，77，1： | 1 |
| 6 | Hepatitis B virus infection and related factors in hemodialysis patients in China-systematic review and meta-analysis 显示文摘 | Wang CY Sun JH Zhu B | 2010 | Ren Fail2010，32，10： | 1 |
| 7 | Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction: a double-blinded, prospective, randomized, controlled trial显示文摘 | Sun ZT Yang CY Cui Z | 2011 | J Anesth2011，25，6： | 1 |
| 8 | Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction:a double-blinded,prospective,randomized,controlled trial显示文摘 | Sun ZT Yang CY Cui Z | 2011 | J Anesthesia2011，25，6： | 1 |
| 9 | Effects of intensive glucose control on incidence of cardiovascular events in patients with type 2 diabetes: a meta-analysis 显示文摘 | Zhang CY Sun AJ Zhang SN | 2010 | Ann Med2010，42，4： | 1 |
| 10 | Effect of intravenous dezocine on fentanyl - induced cough during generalanesthesia induction : a doub- le- blinded, prospective, randomized, controlledtrial显示文摘 | Sun ZT Yang CY Cui Z | 2011 | J Anesth2011，25，： | 1 |
| 11 | Highly water-dispersible biocompatible magnetite particles with low cytotoxicity stabilized by citrate groups显示文摘 | Liu J Sun ZK Deng YH Zou Y Li CY Guo XH | 2009 | Angew Chem Int Ed2009，48，： | 1 |
| 12 | Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification 显示文摘 | Tsai KL Sun Y J Huang CY | 2007 | Nucleic Acids Res2007，35，20： | 1 |
| 13 | An assessment of the efficacy and safety of sildenafil administered to patients with erectile dysfunction referred for posterior urethroplasty :a single-center experience 显示文摘 | Fu Q Sun XJ Tang CY | 2012 | J Sex Med2012，9，1： | 1 |
| 14 | The inflammatory modulation effect of glutamine-enriehed total parenteral nutrition in post- operative gastrointestinal cancer patients显示文摘 | Lu CY Shih YL Sun LC | 2011 | Am Surg2011，77，1： | 1 |
| 15 | Effect of intravenous d-ezocine on fentonyl-induced cough during general anesthesia induction:a double-hlinded,prospective, randomized, controlled trial 显示文摘 | SUN Z T YANG CY CUI Z | 2011 | J Anesth2011，25，6： | 1 |
| 16 | Taurine protected kidney from oxidative injury through mitochondrial-linked pathway in a rat model of nephrolithiasis显示文摘 | LI CY DENG YL SUN BH | 2009 | Urol Res2009，37，4： | 1 |
| 17 | Thermoresponsive keto- profen-imprinted monolith prepared in Ionic liquid显示文摘 | Sun X Zhao CY Wang XH | 2014 | Anal Bioanal Chem2014，406，22： | 1 |
| 18 | Effect of levosimendan on esti- mated glomerular filtration rate in hospitalized patients with decom- pensated heart failure and renal dysfunction显示文摘 | Hou ZQ Sun ZX Su CY | 2013 | Cardiovasc Ther2013，31，2： | 1 |
| 19 | Cornea-specific expression of K12 keratin during mouse development 显示文摘 | Liu CY Zhu G Westerhausen LA Converse R Kao CW Sun TT | 1993 | Curr Eye Res1993，12，11： | 1 |
| 20 | Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction: a double-blinded, prospective, randomized, controlled trial 显示文摘 | Sun ZT Yang CY Cui Z | 2011 | J Anesth2011，25，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员