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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | The larvicidal activity of Agave sisalana against L4 larvae of Aedes aegypti is mediated by internal necrosis and inhibition of nitric oxide production显示文摘 | Fabiola C. Nunes Jacqueline A. Leite Louise H. G. Oliveira Patrícia A. P. S. Sousa Márcio C. Menezes Jo?o P. S. Moraes Sandra R. Mascarenhas Valdir A. Braga | 2015 | Parasitology Research2015，，2： | 1 |
| 3 | Industrial application of AISI 4340 steels treated in cathodic cage plasma nitriding technique显示文摘 | RIBEIRO K J B de SOUSA R R M de ARAJO F O | 2008 | Materials Science and Engineering:2008，479，： | 1 |
| 4 | Mucoadhesive platforms for targeted delivery to the colon显示文摘 | Felipe J.O. Varum Francisco Veiga Jo?o S. Sousa Abdul W. Basit | 2011 | International Journal of Pharmaceutics2011，，1： | 1 |
| 5 | Inhibition of tissue inflammation and bacterial translocation as ones of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice显示文摘 | Flaviano S. Martins Angélica T. Vieira Samir D.A. Elian Rosa M.E. Arantes Fabiana C.P. Tiago Lirlandia P. Sousa Helena R.C. Araújo Paulo F. Pimenta Cláudio A. Bonjardim Jacques R. Nicoli Mauro M. Teixeira | 2013 | Microbes and Infection2013，，： | 1 |
| 6 | The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms显示文摘 | Karine Maria Martins Bezerra Carvalho José Delano Barreto Marinho Filho Tiago Sousa de Melo Ana Jérsia Araújo Josiane da Silva Quetz Maria do Perpétuo Socorro Saldanha da Cunha Karina Moura de Melo Armenio Andre de Carvalho Almeida da Silva Adriana Rocha | 2015 | Evidence-Based Complementary and Alternative Medicine2015，，： | 1 |
| 7 | Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes显示文摘 | Ara(u)jo EP De Sousa CT Ueno M | 2007 | Endocrinology2007，148，12： | 1 |
| 8 | Multidimensional optimization of promising antitumor xanthone derivatives显示文摘 | Carlos M.G. Azevedo Carlos M.M. Afonso Diana Sousa Raquel T. Lima M. Helena Vasconcelos Madalena Pedro Jo?o Barbosa Arlene G. Corrêa Salette Reis Madalena M.M. Pinto | 2013 | Bioorganic & Medicinal Chemistry2013，，11： | 1 |
| 9 | Modified binary PSO for feature selection using SVM applied to mortality prediction of septic patients显示文摘 | Susana M. Vieira Luís F. Mendon?a Gon?alo J. Farinha Jo?o M.C. Sousa | 2013 | Applied Soft Computing Journal2013，，8： | 1 |
| 10 | Incidence of Salmonella from poultry products and their susceptibility to antimicrobial agents显示文摘 | Patr??cia Antunes Cristina Réu Jo?o Carlos Sousa Lu??sa Peixe Nazaré Pestana | 2002 | International Journal of Food Microbiology2002，，2： | 1 |
| 11 | Less Than 12 Nodes in the Surgical Specimen After Total Mesorectal Excision Following Neoadjuvant Chemoradiation: It means more than you think!显示文摘 | Luiz Felipe de Campos-Lobato Luca Stocchi Jo?o Batista de Sousa Martin Buta Ian C. Lavery Victor W. Fazio David W. Dietz Matthew F. Kalady | 2013 | Annals of Surgical Oncology2013，，11： | 1 |
| 12 | Ocimum basilicum:antibacterial activity and association study with antibiotics against bacteria of clinical importance显示文摘 | Araújo Silva V Pereira da Sousa J | 2015 | Pharm Biol2015，10，10： | 1 |
| 13 | Cathodic cage nitriding of samples with different dimensions显示文摘 | Sousa R R M de Arau jo F 0 de Ribeiro K J B | 2007 | Materials Science and Engineering A2007，465，12： | 1 |
| 14 | Renal denervation in patients with resistant hypertension: Six-month results显示文摘 | Hélder Dores Manuel de Sousa Almeida Pedro de Araújo Gon?alves Patrícia Branco Augusta Gaspar Henrique Sousa Angela Canha Gomes Maria Jo?o Andrade Maria Salomé Carvalho Rui Campante Teles Luís Raposo Henrique Mesquita Gabriel Francisco Pereira Machado Mig | 2014 | Revista Portuguesa de Cardiologia (English Edition)2014，，： | 1 |
| 15 | Optimiza- tion of levofloxacin-loaded crosslinked chitosan microspheres for in- haled aerosol therapy显示文摘 | Marisa C Gaspar Jo Alberto A C C Pais | 2015 | Eur J Pharm Biopharm2015，96，： | 1 |
| 16 | Performance index: An expeditious tool to screen for improved drought resistance in the Lathyrus genus显示文摘Some species of the Lathyrus genus are among the most promising crops for marginal lands, with high resilience to drought, flood, and fungal diseases, combined with high yields and seed nutritional value. However, lack of knowledge on the mechanisms underlying its outstanding performance and methodologies to identify elite genotypes has hampered its proper use in breeding. Chlorophyll a fast fluorescence transient(JIP test), was used to evaluate water deficit(WD)resistance in Lathyrus genus. Our results reveal unaltered photochemical values for all studied genotypes showing resistance to mild WD. Under severe WD, two Lathyrus sativus genotypes showed remarkable resilience maintaining the photochemical efficiency, contrary to other genotypes studied.Performance index(PIABS) is the best parameter to screen genotypes with improved performance and grain production under WD. Moreover, we found that JIP indices are good indicators of genotypic grain production under WD. Quantum yield of electron transport(wEo) and efficiency with which trapped excitons can move electrons further than QA(c0)revealed as important traits related to improved photosynthetic performance and should be exploited in future Lathyrus germplasm improvements. The JIP test herein described showed to be an expeditious tool to screen and to identify elite genotypes with improved drought resistance. | Susana Silvestre Susana de Sousa Araújo Maria Carlota Vaz Patto Jorge Marques da Silva | 2014 | Journal of Integrative Plant Biology2014，56，7： | 1 |
| 17 | Mucoadhesive plat- forms for targeted delivery to the colon显示文摘 | VARUM F JO VEGIA F SOUSA JS | 2011 | Int J Pharm2011，420，1： | 1 |
| 18 | The usefulness of the head-up tilt test in patients with suspected epilepsy显示文摘 | Inês Rangel Jo?o Freitas Ana Sofia Correia Alexandra Sousa Ana Lebreiro Carla de Sousa Maria Júlia Maciel Elsa Azevedo | 2014 | Seizure: European Journal of Epilepsy2014，，： | 1 |
| 19 | Association between weight at birth and body composition in childhood: a Brazilian cohort study显示文摘 | Pereira-Freire JA Lemos JO de Sousa AF | 2015 | Early Hum Dev2015，91，8： | 1 |
| 20 | Use of hybrid chitosan membranes and human mesenchymal stem cells from the Wharton jelly of umbilical cord for promoting nerve regeneration in an axonotmesis rat model显示文摘Many studies have been dedicated to the development of scaffolds for improving post-traumatic nerve regeneration. The goal of this study was to assess the effect on nerve regeneration, associating a hybrid chitosan membrane with non-differentiated human mesenchymal stem cells isolated from Wharton's jelly of umbilical cord, in peripheral nerve reconstruction after crush injury. Chromosome analysis on human mesenchymal stem cell line from Wharton's jelly was carried out and no structural alterations were found in metaphase. Chitosan membranes were previously tested in vitro, to assess their ability in supporting human mesenchymal stem cell survival, expansion, and differentiation. For the in vivo testing, Sasco Sprague adult rats were divided in 4 groups of 6 or 7 animals each:Group 1, sciatic axonotmesis injury without any other intervention (Group 1-Crush); Group 2, the axonotmesis lesion of 3 mm was infiltrated with a suspension of 1 250-1 500 human mesenchymal stem cells (total volume of 50 μL) (Group 2-CrushCell); Group 3, axonotmesis lesion of 3 mm was enwrapped with a chitosan type III membrane covered with a monolayer of non-differentiated human mesenchymal stem cells (Group 3-CrushChitIIICell) and Group 4, axonotmesis lesion of 3 mm was enwrapped with a chitosan type III membrane (Group 4-CrushChitIII). Motor and sensory functional recovery was evaluated throughout a healing period of 12 weeks using sciatic functional index, static sciatic index, extensor postural thrust, and withdrawal reflex latency. Stereological analysis was carried out on regenerated nerve fibers. Results showed that infiltration of human mesenchymal stem cells, or the combination of chitosan membrane enwrapment and human mesenchymal stem cell enrichment after nerve crush injury provide a slight advantage to post-traumatic nerve regeneration. Results obtained with chitosan type III membrane alone confirmed that they significantly improve post-traumatic axonal regrowth and may represent a very promising clinical tool in peripheral nerve reconstructive surgery. Yet, umbilical cord human mesenchymal stem cells, that can be expanded in culture and induced toform several different types of cells, may prove, in future experiments, to be a new source of cells for cell therapy, including targets such as peripheral nerve and muscle. | Andrea Gärtner Tiago Pereira Maria Joāo Simōes Paulo AS Armada-da-Silva Miguel L França Rosa Sousa Simone Bompasso Stefania Raimondo Yuki Shirosaki Yuri Nakamura Satoshi Hayakawa Akiyoshi Osakah Beatriz Porto Ana Lúcia Luís Artur SP Varejāo Ana Colette Maurício | 2012 | Neural Regeneration Research2012，7，29： | 1 |
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