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| 1 | MRI of magnetically labeled mesenchymal stem cells in hepatic failure model显示文摘AIM:To track intravascularly transplanted mesenchymal stem cells (MSCs) labeled with superparamagnetic iron oxide (SPIO) by using magnetic resonance imaging (MRI) in an experimental rabbit model of hepatic failure.METHODS:Human MSCs labeled with FDA-approved SPIO particles (Feridex) were transplanted via the mes-enteric vein into rabbits (n=16) with carbon tetrachloride-induced hepatic failure.Magnetic resonance (MR) examinations were performed with a 3.0 T clinical scanner immediately before and 2 h and 1,3,and 7 d after transplantation.Signal intensity (SI) changes on T2weighted MRI were measured,and correlation between MR findings and histomorphologic findings was also investigated.RESULTS:SI on T2-weighted MRI decreased significantly in the liver 2 h after injection of human MSCs and returned gradually to the levels found before injection in 7 d.Changes in SI in the liver at 2 h,1,3,and 7 d were 41.87% ± 9.63%,10.42% ± 4.3%,5.12% ± 1.9%,3.75% ± 1.2%,respectively (P < 0.001).Histologic analyses confirmed the presence of MSCs in the liver,localized mainly in the sinusoids in early period (2 h and 1 d) and concentrated to the border zone in late period (3 and 7 d).The number of iron-positive cells in the liver at 2 h and on 1,3 and 7 d after transplantation was 29.2 ± 4.8,10.1 ± 3.7,6.7 ± 2.2,and 5.8 ± 2.1,respectively (P=0.013).CONCLUSION:Intravascularly injected SPIO-labeled MSCs in an experimental rabbit model of hepatic failure can be detected and followed with MRI. | Kyu Ri Son Se Young Chung Hyo-Cheol Kim Hoe Suk Kim Seung Hong Choi Jeong Min Lee Woo Kyung Moon | 2010 | World Journal of Gastroenterology2010，16，44： | 4 |
| 2 | Percutaneous balloon valvulopasty: a new method for treating congenital pulmonary valve stenosis 显示文摘 | Kan JS White RI Milchell SE | 1982 | N Engl J MED1982，307，12： | 1 |
| 3 | Percutaneous balloon Valvuplasty: A new method for treating congenital pulnionary Valve stenosts 显示文摘 | kan JS white RI Jr Mitchell SE | 1952 | N Engl J reed1952，307，： | 1 |
| 4 | Percutaneous balloon valvuloplasty:a new method for treating congenital pulmonary-value stenosis显示文摘 | Kan JS White RI Mitchell SE | 1982 | N Engl J Med1982，307，9： | 1 |
| 5 | The use of an objective structured clinical examination with postgraduate residents in pediatric显示文摘 | Hilliard RI Tallett SE | 1998 | Arch Pediat r Adolesc Med1998，152，： | 1 |
| 6 | Global hemispheric CT hypoperfusion may differentiate headache with associated neurological deficits and lymphocytosis from acute stroke显示文摘 | Pettersen JA Aviv RI Black SE | | 0，，： | 1 |
| 7 | Percutaneous balloon valvuloplasty:a new method for treating congenital pulmonaryvalve stenosis显示文摘 | Kan JS White RI Jr Mitchell SE | 1982 | N Engl J Med1982，307，9： | 1 |
| 8 | Hematopoietic stem -cell transplantation for the treatment of severe combined immunodeficiency 显示文摘 | Buckley RH Schiff SE Schiff RI | 1999 | N Engl J Med1999，340，7： | 1 |
| 9 | Combining periodic and continuous sodium hypochlorite treatment to control biofilms in dental unit water systems 显示文摘 | Plamondon TJ Mill SE | 1999 | JADA1999，131，： | 1 |
| 10 | Human severe combined immunodeficiency : Genetic, phenotypic, and functional diversity in one hundred eight infants 显示文摘 | Buckley RH Schiff RI Schiff SE | 1997 | J Pediatr1997，130，3： | 1 |
| 11 | Porcutaneous transluminal balloon valvuloplasty: A new method for treating congenital pulmonary valve stenosis 显示文摘 | Kan JS White RI Mitchell SE | 1982 | N Engl J Med1982，307，3： | 1 |
| 12 | Percutaneous balloon valvuloplasty: a new method for treating congenital pulmonary-valve stenosis 显示文摘 | Kan JS White RI Jr Mitchell SE | 1982 | N Engl J Med1982，307，9： | 1 |
| 13 | Percutaneous balloon valvuloplasty: a new method for treating congenital pulmonary valve stenosis 显示文摘 | Kan JS White RI Mitchell SE | 1982 | N Engl J Med1982，307，9： | 1 |
| 14 | Comparison of methods to enumerate bacteria in dental unit waterlines 显示文摘 | Plamondon TJ Mills SE | 1999 | Curr Microbiol1999，38，： | 1 |
| 15 | Validation of an in-office dental unit water monitoring technique 显示文摘 | Plamondon TJ Mills SE | 1998 | JADA1998，129，： | 1 |
| 16 | Percutaneous transluminal balloon valvuloplasty for pulmonary valve stenosis 显示文摘 | Kan JS White RI Mitchell SE | 1984 | Circulation1984，69，3： | 1 |
| 17 | Human severe combined immunodeficiency : genetic, phenotypic, and functional diversity in one hundred eight infants显示文摘 | Buckley RH Schiff RI Schiff SE | 1997 | J Pediatr1997，130，： | 1 |
| 18 | Pereutaneous balloon valvulnplasty : a newmethod for treating congenital pulmonary-value stenosis 显示文摘 | Kan JS White RI Mitchell SE | 1982 | N En- gl J Med1982，307，9： | 1 |
| 19 | Angioarchitecture of pulmonary arteriovenous malformations: an important consideration before embolotherapy显示文摘 | White RI Mitchell SE Barth KH | 1983 | AJR1983，140，4： | 1 |
| 20 | Angioarchitecture of pulmonary arteriovenous malformations:an important consideration before embolotherapy显示文摘 | White RI Jr Mitchell SE Barth KH | 1983 | AJR1983，140，： | 1 |
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