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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Origins of breast cancer subtypes and therapeutic implications 显示文摘 | Sims AH Howell A Howell S J Clarke R B | 2007 | Nature Clin Pract Oncol2007，4，12： | 1 |
| 3 | Evaluation of fly ash as a soil amendment for the Atantic coastal plain:Ⅰ, soil hydraulic properties and elemental leaching显示文摘 | Ghodrati M Sims J T Vasilas B L | 1995 | Water Air and soil pollution1995，8，1： | 1 |
| 4 | Phosphorus loss in agricultural drainage: Historical perspective and current research显示文摘 | Sims J T Simard R R Joern B C | 1998 | Journal of Environmental Quality1998，27，： | 1 |
| 5 | Nonmehing-flesh trait in peaches is not related to low ethylene production rates显示文摘 | Brovelli E A Brecht J K Sherman W B Sims C A | 1999 | HortScience1999，34，： | 1 |
| 6 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 7 | Nutrient management for intensive animal agriculture:policies and practices for sustainabl ity 显示文摘 | Sims J T BergstrOm Bowman B T | 2005 | Soil Use and Management2005，21，： | 1 |
| 8 | A parametric formulation of the generalized spectral subtraction method 显示文摘 | Sim B L Tong Y C Chang J S | 1998 | IEEE Trans on Speech and Audio Pro- cessing1998，6，4： | 1 |
| 9 | Influence of dietary energy source on performance and fatty liver syn- drome in White Leghorn laying hens显示文摘 | Bragg D B Sim J S Hodgson G C | 1973 | Poult Sci1973，52，2： | 1 |
| 10 | Orientation characterization and photoconductive properties of ethylenediamine bridged silicon phthalocyanine polymer thin film显示文摘 | SIM J H ONG B S REED C A | 1996 | Thin Solid Films1996，40，2： | 1 |
| 11 | Changes in cell wall composition during ripening of grape berries显示文摘 | NUNAN K J SIMS IM BACIC A ROBINSON S P F1NCHER G B | 1998 | Plant Physiology1998，118，3： | 1 |
| 12 | Field performance of transgenic cotton containing the Bt gene显示文摘 | Stone T B Sims S R Marron P G J | 1989 | Proc Invertebr Pathol1989，53，： | 1 |
| 13 | Phosphorus Loss in Agricultural Drainage: Historical Perspective and Current Research显示文摘 | Sims J T Simard R R Joern B C | 1998 | Journal environmental quality1998，27，2： | 1 |
| 14 | B-type natriuretic peptide and mortality in extremely low birth weight infants with pulmonary hypertension:a retrospective cohort analysis显示文摘 | Cuna A Kandasamy J Sims B | 2014 | BMC Pediatr2014，14，： | 1 |
| 15 | The impact of glycosylation on the biological function and structure of human immunoglobulin's显示文摘 | Arnold J N Wormald M R Sim R B | 2007 | Ann Rev Immunol2007，25，： | 1 |
| 16 | The impact of glyeosylation on the biological function and structure of human immunoglobulin's显示文摘 | Arnold J N WormaldMR Sim R B | 2007 | Ann Rev Immunol2007，25，： | 1 |
| 17 | Accelerated deployment of an agricultural nutrient management tool:the maryland phosphorus site index显示文摘 | Coale F J Sims J T Leytem A B | 2002 | J Environ Qual2002，31，： | 1 |
| 18 | Enhancing the benefits of fly ash as a soil amendment by pre-leaching 显示文摘 | Ghodrati M Sims J T Vasilas B L | 1995 | Soil Science1995，159，： | 1 |
| 19 | Urinary inconti- nence in a community sample of older adults:prevalence and impact on quality of life显示文摘 | Sims J Browning C Lundgren-Lindquist B | 2011 | Disabil Rehabil2011，33，1516： | 1 |
| 20 | Evaluation of fly ash as a soil a mendment for the Atlantic coastal plain:Ⅱ Soil chemical properties and cop grow显示文摘 | Vasilas B L Ghodrati M | 1995 | Water Air and Soil Pollution1995，81，34： | 1 |
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