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| 1 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 2 | Common-mode EMI study and reduction technique for the interleaved multichannel PFC converter显示文摘 | KONG Pengju WANG Shuo LEE F C | 2008 | IEEE Transactions on Power Electronics2008，23，5： | 1 |
| 3 | Characterization and parasitic extraction of EMI filters using scattering parameters 显示文摘 | Wang Shuo Lee F C | 2005 | IEEE Transactions on Power Electronics2005，20，2： | 1 |
| 4 | Testing community velocity models for southern california using the ambient seismic field显示文摘 | Shuo M German A P Gregory C B | 2008 | Bulletin of the Seismological Society of America2008，98，6： | 1 |
| 5 | Common mode noise reduction for boost converters using general balance technique显示文摘 | WANG Shuo KONG Pengju LEE F C | 2007 | IEEE Transactions on Power Electronics2007，22，4： | 1 |
| 6 | Reducing common-mode noise in two-switch forward converter 显示文摘 | Kong Pengju Wang Shuo Lee F C | 2011 | IEEE Transactions on Power Electronics2011，26，5： | 1 |
| 7 | Taoism, Temples and Tourists: The Case of Mazu Pilgrimage Tourism 显示文摘 | SHUO Y S RYAN C LIU G | 2009 | Tourism Management2009，30，4： | 1 |
| 8 | Isolation and characterization of multipotent human periodontal ligament stem cells显示文摘 | Isabel C Gay Shuo Chen Mary MacDougall | 2007 | Orthod Craniofacial Res2007，10，： | 1 |
| 9 | Inductor winding capacitance cancellation using mutual capacitance concept for noise reduction application显示文摘 | Wang Shuo Lee F C Van Wyk J D | | 0，，02： | 1 |
| 10 | Effects of parasitic parameters on EMI filter performance显示文摘 | Wang Shuo Lee F C Chen D Y | | 0，，03： | 1 |
| 11 | Characterization and parasitic extraction of EMI filters using seat- tering parameters 显示文摘 | WANG Shuo LEE F C ODENDAAL W G | 2005 | IEEE Transactions on Power Electronics2005，20，2： | 1 |
| 12 | Isolation and character- ization of multipotent human periodontalligament stem cells 显示文摘 | Isabel C Gay Alabama Shuo Chen | 2007 | Orthod Craniofaeial Res2007，10，3： | 1 |
| 13 | Taoism, temples and tourists : The case of Mazu pilgrimage tourism 显示文摘 | Shuo Y S Ryan C Liu G | 2009 | Tourism Management2009，30，4： | 1 |
| 14 | Differential effect of IL- 27 on developing versus committed Th17 Cells 显示文摘 | Mohamed EB Bogoljub C Shuo Y | 2009 | Immunol2009，183，8： | 1 |
| 15 | Neutralizing antibodies to Oil-18 ameliorate experimental autoimmune neuritis by counter regulation of autoreactive Th1 responses to peripheral myeln antigen显示文摘 | Shuo Y Zhiguo C Elihard M | 2002 | J Neuropathol Exp Neurol2002，61，： | 1 |
| 16 | Arthroscopically assisted osteosynthesis for tibial plateau fractures 显示文摘 | Shuo SH En-Kai C Chan YS | 2003 | J Trauma2003，54，2： | 1 |
| 17 | Design of Inductor Winding Capacitance Cancellation for EMI Suppression显示文摘 | Wang Shuo Lee Fred C Jacobus Daniel Van Wyk | | 0，，06： | 1 |
| 18 | Effects of parasitic parameters on EMI filter performance显示文摘 | Wang Shuo Lee Fred C Chen Danyang | 2004 | IEEE Transactions on Power Electronics2004，19，3： | 1 |
| 19 | Willem gerhardus odendaal,characterization,evaluation and design of noise separator for conducted EMI noise diagnosis显示文摘 | Fred C Lee | 2005 | IEEE Trans on Power Electronics2005，20，4： | 1 |
| 20 | Acute toxicity, biochemical and gene expression responses of the earthworm Eisenia fetida exposed to polycyclic musks显示文摘 | Chun C Qixing Z Shuo L | 2011 | Chemosphere2011，83，8： | 1 |
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