|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Undifferentiated embryonal sarcoma of the liver:Clinical characteristics and outcomes显示文摘BACKGROUND Undifferentiated embryonal sarcoma of the liver(UESL)is a rare liver malignancy originating from primary mesenchymal tissue.The clinical manifestations,laboratory tests,and imaging examinations of the disease lack specificity and the preoperative misdiagnosis rate is high.The overall prognosis is poor and survival rate is low.AIM To investigate the diagnosis,treatment,and prognosis of UESL.METHODS We performed a retrospective,single-center cohort study in Shengjing Hospital of China Medical University,which is a central hospital in northeast China.From 2005 to 2017,we recruited 14 patients with pathologically confirmed UESL.We analyzed the clinical manifestations,laboratory tests,imaging examinations,pathological examinations,therapy,and prognosis of these patients.RESULTS There were nine males and five females aged 2-60 years old included in the study.The major initial symptoms were abdominal pain(71.43%)and fever(57.14%).Preoperative laboratory tests revealed that seven patients had increased leukocyte levels,four showed a decrease in hemoglobin levels,seven patients had increased glutamyl transpeptidase levels,nine had increased lactate dehydrogenase levels,and three showed an increase in carbohydrate antigen 199.There was no difference in the rate of misdiagnosis in preoperative imaging examinations of UESL between adults and children(6/6 vs 5/8,P=0.091).The survival rate after complete resection was 6/10,while that after incomplete resection was 0/4(P=0.040),suggesting that complete resection is important to improve survival rate.In total,five out of the eight children achieved survival.During the follow-up,the maximum survival time was shown to be 11 years and minimum survival time was 6 mo.Six adult patients relapsed late after surgery and all of them died.CONCLUSION Preoperative imaging examination for UESL has a high misdiagnosis rate.Multidisciplinary collaboration can improve the diagnostic accuracy of UESL.Complete surgical resection is the first choice for treatment of UESL. | Chong Zhang Chang-Jun Jia Can Xu Qiu-Ju Sheng Xiao-Guang Dou Yang Ding | 2020 | World Journal of Clinical Cases2020，8，20： | 8 |
| 2 | A New Cyclic Peptide from Schnabelia tetradonta显示文摘A new cyclic octapeptide (schnabepeptide B) was isolated from the aerial part ofSchnabelia tetradonta (Sun) C. Y. Wu et C. Chen (Lamiaceae). Its structure was elucidated ascyclo-(NH-Trp-Gly1-Leu1-Gly2-Pro1-Pro2-Leu2-Pro3-CO) on the basis of extensive 2D NMR andMS spectra. | Hui DOU, Yan ZHOU, Shu lin PENG, Li Sheng DING Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041 | 2003 | Chinese Chemical Letters2003，14，9： | 7 |
| 3 | Inhibitory effects of EGFR antisense oligodeoxynucleotide in human colorectal cancer cell line显示文摘INTRODUCTIONEpidermal-growth-factor receptor(EGFR) is apolypeptide with 1186 amino acids,which binds toEGF family growth factors.Two major naturalligands in the family interact with EGFR:one isEGF,the other is transforming growth factor-α(TGF-α).When EGF or TGF-α,binds to EGFR,tyrosine kinase activity is induced which in turntriggers a series of events regulating the cellgrowth.The importance of EGFR in growthregulating pathways was confirmed by the fact | Yong He Jun Zhou Jin Sheng Wu Ke Feng Dou | 2000 | World Journal of Gastroenterology2000，6，5： | 5 |
| 4 | Mesenchymal stem cells rescue acute hepatic failure by polarizing M2 macrophages显示文摘AIM To investigate whether M1 or M2 polarization contributes to the therapeutic effects of mesenchymal stem cells(MSCs) in acute hepatic failure(AHF).METHODS MSCs were transfused into rats with AHF induced by D-galactosamine(DGal N). The therapeutic effects of MSCs were evaluated based on survival rate and hepatocyte proliferation and apoptosis. Hepatocyte regeneration capacity was evaluated by the expression of the hepatic progenitor surface marker epithelial cell adhesion molecule(Ep CAM). Macrophage polarization was analyzed by M1 markers [CD68,tumor necrosis factor alpha(TNF-α),interferon-γ(IFN-γ),inducible nitric oxide synthase(INOS)] and M2 markers [CD163,interleukin(IL)-4,IL-10,arginase-1(Arg-1)] in the survival and death groups after MSC transplantation.RESULTS The survival rate in the MSC-treated group was increased compared with the DPBS-treated control group(37.5% vs 10%). MSC treatment protected rats with AHF by reducing apoptotic hepatocytes and promoting hepatocyte regeneration. Immunohistochemical analysis showed that MSC treatment significantly increased the expression of Ep CAM compared with the control groups(P < 0.001). Expression of Ep CAM in the survival group was significantly up-regulated compared with the death group after MSC transplantation(P = 0.003). Transplantation of MSCs significantly improved the expression of CD163 and increased the gene expression of IL-10 and Arg-1 in the survival group. IL-4 concentrations were significantly increased compared to the death group after MSC transplantation(88.51 ± 24.51 pg/m L vs 34.61 ± 6.6 pg/m L,P < 0.001). In contrast,macrophages showed strong expression of CD68,TNF-α,and INOS in the death group. The concentration of IFN-γ was significantly increased compared to the survival group after MSC transplantation(542.11 ± 51.59 pg/m L vs 104.07 ± 42.80 pg/m L,P < 0.001).CONCLUSION M2 polarization contributes to the therapeutic effects of MSCs in AHF by altering levels of anti-inflammatory and pro-inflammatory factors. | yan-wei li chong zhang qiu-ju sheng han bai yang ding xiao-guang dou | 2017 | World Journal of Gastroenterology2017，23，45： | 3 |
| 5 | Programmed death 1, ligand 1 and 2 correlated genes and their association with mutation, immune infiltration and clinical outcomes of hepatocellular carcinoma显示文摘BACKGROUND The exact regulation network of programmed death 1(PD-1), programmed death ligand 1(PD-L1), and programmed death ligand 2(PD-L2) signaling in immune escape is largely unknown. We aimed to describe the gene expression profiles related to PD-1 as well as its ligands PD-L1 and PD-L2, thus deciphering their possible biological processes in hepatocellular carcinoma(HCC).AIM To find the possible mechanism of function of PD-1, PD-L1, and PD-L2 in HCC.METHODS Based on the expression data of HCC from The Cancer Genome Atlas, the PD-1/PD-L1/PD-L2 related genes were screened by weighted correlation network analysis method and the biological processes of certain genes were enriched. Relation of PD1/PD-L1/PD-L2 with immune infiltration and checkpoints was investigated by co-expression analysis. The roles of PD-1/PD-L1/PD-L2 in determination of clinical outcome were also analyzed.RESULTS Mutations of calcium voltage-gated channel subunit alpha1 E, catenin beta 1, ryanodine receptor 2, tumor suppressor protein p53, and Titin altered PD-1/PDL1/PD-L2 expression profiles in HCC. PD-1, PD-L1, and PD-L2 related genes were mainly enriched in biological procedures of T cell activation, cell adhesion, and other important lymphocyte effects. In addition, PD-1/PD-L1/PD-L2 was related with immune infiltration of CD8 T cells, cytotoxic lymphocytes,fibroblasts, and myeloid dendritic cells. Immune checkpoints of CTLA4, CD27, CD80, CD86, and CD28 were significantly related to the PD-1/PD-L1/PD-L2 axis. Clinically, PD-1 and PD-L2 expression was correlated with recurrence(P = 0.005 for both), but there was no significant correlation between their expression and HCC patient survival.CONCLUSION Mutations of key genes influence PD-1, PD-L1, and PD-L2 expression. PD-1, PDL1, and PD-L2 related genes participate in T cell activation, cell adhesion, and other important lymphocyte effects. The finding that PD-1/PD-L1/PD-L2 is related to immune infiltration and other immune checkpoints would expand our understanding of promising anti-PD-1 immunotherapy. | Qiu-Ju Sheng Wen-Yue Tian Xiao-Guang Dou Chong Zhang Yan-Wei Li Chao Han Yao-Xin Fan Ping-Ping Lai Yang Ding | 2020 | World Journal of Gastrointestinal Oncology2020，12，11： | 2 |
| 6 | Carbon Materials for Chemical Capacitive Energy Storage显示文摘 | Yunpu Zhai Yuqian Dou Dongyuan Zhao Pasquale F. Fulvio Richard T. Mayes Sheng Dai | 2011 | Adv. Mater2011，，42： | 2 |
| 7 | Regiospecificand enantioselective synthesis of methylated metabolites oftea catechins显示文摘 | Sheng BiaoWan Q Ping Dou Tak Hang Chan | 2006 | Tetrahedron2006，62，25： | 1 |
| 8 | Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease显示文摘Liver fibrosis is a pathological condition characterized by replacement of normal liver tissue with scar tissue,and also the leading cause of liver-related death worldwide.During the treatment of liver fibrosis,in addition to antiviral therapy or removal of inducers,there remains a lack of specific and effective treatment strategies.For thousands of years,Chinese herbal medicines(CHMs)have been widely used to treat liver fibrosis in clinical setting.CHMs are effective for liver fibrosis,though its mechanisms of action are unclear.In recent years,many studies have attempted to determine the possible mechanisms of action of CHMs in treating liver fibrosis.There have been substantial improvements in the experimental investigation of CHMs which have greatly promoted the understanding of anti-liver fibrosis mechanisms.In this review,the role of CHMs in the treatment of liver fibrosis is described,based on studies over the past decade,which has addressed the various mechanisms and signaling pathways that mediate therapeutic efficacy.Among them,inhibition of stellate cell activation is identified as the most common mechanism.This article provides insights into the research direction of CHMs,in order to expand its clinical application range and improve its effectiveness. | LI Yanwei LU Yunrui NIAN Mozuo SHENG Qiuju ZHANG Chong HAN Chao DOU Xiaoguang DING Yang | 2023 | Chinese Journal of Natural Medicines2023，21，9： | 1 |
| 9 | Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives显示文摘11-Oxo-10,11-dihydroxy-5H-indolo [3,2, b ]quinoline7 羧基的酸被 polyphosphorous 酸明确地获得有最佳的反应条件的催化环合。生物试金证明它潜在地禁止 proteasomal 在 vitro 的像糜蛋白酶的活动并且压制乳癌房间生长。 | Sheng Biao Wan Zhe Lin Liu Di Chen Qing Ping Dou Tao Jiang | 2007 | Chinese Chemical Letters2007，18，10： | 1 |
| 10 | New Curvature - Compensation Technique for CMOS Band gap Reference with Sub - 1 - V Operation 显示文摘 | Ming - Dou Ker Jung - Sheng Chen Ching - Yun Chu | 2005 | IEEE Journal of Solid State Circuits2005，，： | 1 |
| 11 | Trajectory analyses of the dust storms over East Asia显示文摘 | Sheng P X Meng G L Dou W Y | 1994 | Acta Meteor Sinica1994，8，2： | 1 |
| 12 | Modified laparo- scopie and open splenectomy and azygoportal dise0nneeti0n for por- tal hypertension 显示文摘 | Dou - Sheng Bai jian - Jun Qian Ping Chen | 2014 | Surg Endosc2014，，28： | 1 |
| 13 | Multiple Effects Tailoring the Self-organization Behaviors of Triphenylene Side-chain Liquid Crystalline Polymers via Changing the Spacer Length显示文摘Long-alkyl tail triphenylene(TP) side-chain liquid crystalline polymers(SCLCPs) with different spacer length(P-m-TP,m =2,3,4,6,8,which is the number of carbon atom in the flexible alkyl spacers) have been successfully synthesized via free radical polymerization.The differential scanning calorimetry(DSC),polarized light microscopy(POM),ultraviolet-visible spectroscopy(UVVis),wide-angle X-ray diffraction(WAXD) and small-angle X-ray scattering(SAXS) measurements were performed to investigate the influence of multiple effects on the self-organization behaviors of P-m-TP,including steric effect,decoupling effect and π-π stacking effect.The experimental results revealed that P-m-TP(m = 2,3,4) formed the columnar phase which was developed by the TP moieties and the main chain as a whole,suggesting that the side-chains had strong steric effect even though the number of spacer length(m)exceeded 4.In addition,the clearing points(Tis) of the polymers were above 300 °C.When m = 6 and 8,the polymers displayed hexagonal columnar phase and exhibited the low Tis(91 and 80 °C respectively),originating from the self-assembly of triphenylene due to the decoupling effect and π-π stacking effect.This work offers a viable and inspiring pathway to control the phase transition temperature and phase structure of TP SCLCPs via simply tailoring the spacer length and increasing the alkyl tail length of TP. | Xiang-Hui Han Xi-Wen Yang Sheng Chen Hang Luo Dou Zhang Hai-Liang Zhang | 2018 | Chinese Journal of Polymer Science2018，36，8： | 1 |
| 14 | HBeAg-negative Patients with Chronic Hepatitis B Virus Infection and Normal Alanine Aminotransferase:Wait or Treat?显示文摘Alanine aminotransferase(ALT)is a common clinical indicator of liver inflammation.The current Chinese guidelines for the management of chronic hepatitis B(CHB)recommend antiviral treatment for patients with detectable hepatitis B virus(HBV)DNA and persistent ALT levels(ALTs)exceeding the upper limit of normal.However,it has been recently reported that patients with chronic HBV infection,especially HBeAg-negative patients with persistently normal ALTs,may have liver biopsy findings of significant inflammation and fibrosis.For HBeAg-negative patients with chronic HBV infection and normal ALTs,many controversial questions have been asked.To treat or not?When to initiate the treatment?Which drug is appropriate?In this review,we summarize the available data on the management of HBeAg-negative patients with chronic HBV infection and normal ALTs with the aim of improving the current clinical management. | Qiuju Sheng Ning Wang Chong Zhang Yaoxin Fan Yanwei Li Chao Han Ziyi Wang Shuqi Wei Xiaoguang Dou Yang Ding | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 15 | Randomized, three‐arm study to optimize lamivudine efficacy in hepatitis B e antigen‐positive chronic hepatitis B patients显示文摘 | Xieer Liang Jun Cheng Yongtao Sun Xinyue Chen Tong Li Hao Wang Jianning Jiang Xiaoping Chen Hui Long Hong Tang Yanyan Yu Jifang Sheng Shijun Chen Junqi Niu Hong Ren Junping Shi Xiaoguang Dou Mobin Wan Jiaji Jiang Qing Xie Guangfeng Shi Qin Ning Chengwei C | 2015 | J Gastroenterol Hepatol2015，，4： | 1 |
| 16 | Anti-IgLON5 disease: a novel topic beyond neuroimmunology显示文摘Anti-IgLON5 disease is a recently defined autoimmune disorder of the nervous system associated with autoantibodies against IgLON5. Given its broad clinical spectrum and extremely complex pathogenesis, as well as difficulties in its early diagnosis and treatment, anti-IgLON5 disease has become the subject of considerable research attention in the field of neuroimmunology. Anti-IgLON5 disease has characteristics of both autoimmunity and neurodegeneration due to the unique activity of the antiIgLON5 antibody. Neuropathologic examination revealed the presence of a tauopathy preferentially affecting the hypothalamus and brainstem tegmentum, potentially broadening our understanding of tauopathies. In contrast to that seen with other autoimmune encephalitis-related antibodies, basic studies have demonstrated that IgLON5 antibody-induced neuronal damage and degeneration are irreversible, indicative of a potential link between autoimmunity and neurodegeneration in antiIgLON5 disease. Herein, we comprehensively review and discuss basic and clinical studies relating to anti-IgLON5 disease to better understand this complicated disorder. | Yi-ZongHeng Zhang You Ni Yi-Ning Gao Ding-Ding Shen Lu He Dou Yin Huan-Yu Meng Qin-Ming Zhou Ji Hu Sheng Chen | 2023 | Neural Regeneration Research2023，18，5： | 1 |
| 17 | A study on the reaction kinetics of HCl removal from high-temperature coal gas显示文摘 | DOU BIN LIN GAO JIN SHENG | 2001 | Fuel Processing Technology2001，72，1： | 1 |
| 18 | Evaluation of Four Candidate VNTR Loci for Genotyping 225 Chinese Clinical Mycobacterium Tuberculosis Complex Strains显示文摘Objective To evaluate four candidate variable number tandem repeat (VNTR) loci for genotyping Mycobacterium tuberculosis complex strains.Methods Genomic sequences for two M.tuberculosis strains (CCDC5079 and CCDC5180) were generated,and using published sequence data,four candidate VNTR loci were identified.The VNTRs were used to genotype 225 Chinese clinical M.tuberculosis complex strains.The discriminatory power of the VNTRs was evaluated using BioNumerics 5.0 software.Results The Hunter-Gaston Index (HGI) for BJ1,BJ2,BJ3,and BJ4 loci was 0.634,0.917,0.697,and 0.910,respectively.Combining all four loci gave an HGI value of 0.995,thus confirming that the genotyping had good discriminatory power.The HGI values for BJ1,BJ2,BJ3,and BJ4,obtained from Beijing family strain genotyping,were 0.447,0.878,0.315,and 0.850,respectively.Combining all four loci produced an HGI value of 0.988 for genotyping the Beijing family strains.We observed unique patterns for M.bovis and M.africanum strains from the four loci.Conclusion We have shown that the four VNTR loci can be successfully used for genotyping M.tuberculosis complex strains.Notably,these new loci may provide additional information about Chinese M.tuberculosis isolates than that currently afforded by established VNTR loci typing. | JIANG Yi LIU Hai Can ZHENG Hua Jun TANG Biao DOU Xiang Feng ZHAO Xiu Qin ZHU Yong Qiang LU Bing WANG Sheng Yue DONG Hai Yan ZHAO Guo Ping ZHANG Yuan Yuan KAN Biao WAN Kang Lin | 2012 | Biomedical and Environmental Sciences2012，25，1： | 1 |
| 19 | Transcriptional programming and functional interactions within the Phytophthora sojae RXLR effector repertoire显示文摘 | WANG Q HAN C FERREIRA A O YU X YE W TRIPATHYS KALE S D GU B SHENG Y SUI Y WANG X ZHANG Z CHENG B DONG S SHAN W ZHENG X DOU D TYLER B WANG Y | 2011 | The Plant Cell2011，23，6： | 1 |
| 20 | Mechanized semantics and refinement of UML-Statecharts显示文摘UML(Unified Modeling Language)是业界建模与分析的事实标准。然而,由于UML的语义信息未被精确定义,我们无法对UML模型之间的精化关系进行验证。本文使用定理证明器Coq形式定义了UML状态图的语义和模型之间的精化关系,形成机械语义。基于机械语义,模型语义信息及精化关系可以被描述为谓词及定理,在定理证明器Coq中进行证明。此方法为可验证的、无错误的建模和精化提供了一个可行的方向。 | Feng SHENG Liang DOU Zong-yuan YANG | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员