|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 2 | Efects of physical and chemical characteristics of surface sediments in the formation of shallow lake algae-induced black bloom显示文摘Surface sediments are closely related to lake black blooms. The dissolved oxygen(DO) distribution and its penetration depth in surface sediments as well as the migration and transformation of redox sensitive elements such as Fe and S at the sediment-water interface are important factors that could influence the formation of the black bloom. In this study, dredged and undredged sediment cores with diferent surface properties were used to simulate black blooms in the laboratory. The Micro Profiling System was employed to explore features of the DO and ∑ H2 S distribution at the sediment-water interface. Physical and chemical characteristics in sediments and pore waters were also analyzed. The results showed that sediment dredging efectively suppressed the black blooms. In the undredged treatment, DO penetration depth was only 50 μm. Fe2+concentrations, ∑ H2 S concentrations, and ∑ H2 S production rates were remarkably higher in surface sediments and pore waters compared to control and dredged treatments. Furthermore, depletion of DO and accumulation of Fe2+and ∑ H2 S in surface sediments and pore waters provided favorable redox environments and necessary material sources for the blooms. The study results proved that physical and chemical characteristics in surface sediments are important factors in the formation of the black bloom, and could provide scientific guidance for emergency treatment and long-term pre-control of black blooms. | Qiushi Shen Cheng Liu Qilin Zhou Jingge Shang Lei Zhang ChengXin Fan | 2013 | Journal of Environmental Sciences2013，25，12： | 43 |
| 3 | The Global Stratotype Section and Point (GSSP) for the boundary between the Capitanian and Wuchiapingian Stage (Permian)显示文摘 | Yugan Jin Shuzhong Shen Charles M. Henderson Xiangdong Wang Wei Wang Yue Wang Changqun Cao Qinghua Shang | 2006 | Episodes2006，29，4： | 39 |
| 4 | Beyond hypoxia: Occurrence and characteristics of black blooms due to the decomposition of the submerged plant Potamogeton crispus in a shallow lake显示文摘Organic matter-induced black blooms(hypoxia and an offensive odor) are a serious ecosystem disasters that have occurred in some large eutrophic shallow lakes in China. In this study, we investigated two separate black blooms that were induced by Potamogeton crispus in Lake Taihu, China. The main physical and chemical characteristics, including color- and odor-related substances, of the black blooms were analyzed. The black blooms were characterized by low dissolved oxygen concentration(close to 0 mg/L), low oxidation-reduction potential, and relatively low pH of overlying water. Notably higher Fe2+and∑S2-were found in the black-bloom waters than in waters not affected by black blooms. The black color of the water may be attributable to the high concentration of these elements, as black FeS was considered to be the main substance causing the black color of blooms in freshwater lakes. Volatile organic sulfur compounds, including dimethyl sulfide, dimethyl disulfide, and dimethyl trisulfide, were very abundant in the black-bloom waters. The massive anoxic degradation of dead Potamogeton crispus plants released dimethyl sulfide, dimethyl disulfide, and dimethyl trisulfide, which were the main odor-causing compounds in the black blooms. The black blooms also induced an increase in ammonium nitrogen and soluble reactive phosphorus levels in the overlying waters. This extreme phenomenon not only heavily influenced the original lake ecosystem but also greatly changed the cycling of Fe, S, and nutrients in the water column. | Qiushi Shen Qilin Zhou Jingge Shang Shiguang Shao Lei Zhang Chengxin Fan | 2014 | Journal of Environmental Sciences2014，26，2： | 33 |
| 5 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 6 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 7 | Impact of different benthic animals on phosphorus dynamics across the sediment-water interface显示文摘As a diagenetic progress, bioturbation influences solute exchange across the sediment-water interface (SWI). Different benthic animals have various mechanical activities in sediment, thereby they may have different effects on solute exchange across the SWI. This laboratory study examined the impacts of different benthic animals on phosphorus dynamics across the SWI. Tubificid worms and Chironomidae larvae were introduced as model organisms which, based on their mechanical activities, belong to upward-conveyors and gallery-diffusers, respectively. The microcosm simulation study was carried out with a continuous flow culture system, and all sediment, water, and worms and larvae specimens were sampled from Taihu Lake, China. To compare their bioturbation effects, the same biomass (17.1 g wet weight (ww)/m 2 ) was adopted for worms and larvae. Worms altered no oxygen penetration depth in sediment, while larvae increased the O 2 penetration depth, compared to the control treatment. Their emergence also enhanced sediment O 2 uptake. The oxidation of ferrous iron in pore water produced ferric iron oxyhydroxides that adsorbed soluble reactive phosphorus (SRP) from the overlying water and pore water. Larvae built obviously oxidized tubes with about 2 mm diameter and the maximum length of 6 cm in sediment, and significantly decreased ferrous iron and SRP in the pore water compared to the control and worms treatments. Worms constructed no visually-oxidized galleries in the sediment in contrast to larvae, and they did not significantly alter SRP in the pore water relative to the control treatment. The adsorption of ferric iron oxyhydroxides to SRP caused by worms and larvae inhibited SRP release from sediment. Comparatively, worms inhibited more SRP release than larvae based on the same biomass, as they successively renewed the ferric iron oxyhydroxides rich oxidation layer through their deposition. | Lei Zhang Xiaozhi Gu Chengxin Fan Jingge Shang Qiushi Shen Zhaode Wang Ji Shen | 2010 | Journal of Environmental Sciences2010，22，11： | 14 |
| 8 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 9 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 10 | Design and development of an oral remdesivir derivative W116 against SARS-CoV-2显示文摘Dear Editor,Since the declaration of COVID-19 as a global pandemic on March 11,2020,this pandemic has been circulating for 17 months throughout the world,leading to more than 200 million infections and nearly 4.4 million deaths as of August 15,2021.The pathogen of COVID-19 is a novel coronavirus named SARS-CoV-2,which shares-79%genome sequence identity with SARS-CoV.1 At the early stage of the COVID-19 outbreak,5ARS-CoV-2 caused great panic in the hardest-hit areas due to its high transmissibility and pathogenicity.To fight the COVID-19 crisis,drug repurposing was immediately pursued in order to find potential therapeutics. | Yuanchao Xie Wanchao Yin Yumin Zhang Weijuan Shang Zhen Wang Xiaodong Luan Guanghui Tian Haji A.Aisa Yechun Xu Gengfu Xiao Jia Li Hualiang Jiang Shuyang Zhanq Leike Zhang H.Eric Xu Jingshan Shen | 2021 | Cell Research2021，31，11： | 12 |
| 11 | Inhibitive effects of anti-oxidative vitamins on mannitol-induced apoptosis of vascular endothelial cells显示文摘Objective: Study blood vessel injury and gene expression indicating vascular endothelial cell apoptosis induced by mannitol with and without administration of anti-oxidative vitamins. Methods: Healthy rabbits were randomly divided into four groups. Mannitol was injected into the vein of the rabbit ear in each animal. Pre-treatment prior to mannitol injection was per- formed with normal saline (group B), vitamin C (group C) and vitamin E (group D). Blood vessel injury was assessed under electron and light microscopy. In a second experiment, cell culture specimen of human umbilical vein endothelial cells were treated with mannitol. Pre-treatment was done with normal saline (sample B), vitamin C (sample C) and vitamin E (sample D). Total RNA was extracted with the original single step procedure, followed by hybridisation and analysis of gene expression. Results: In the animal experiment, serious blood vessel injury was seen in group A and group B. Group D showed light injury only, and normal tissue without pathological changes was seen in group C. Of all 330 apoptosis-related genes analysed in human cell culture specimen, no significant difference was seen after pre-treatment with normal saline, compared with the gene chip without pre-treatment. On the gene chip pre-treated with vitamin C, 45 apoptosis genes were down-regulated and 34 anti-apoptosis genes were up-regulated. Pre-treatment with vitamin E resulted in the down-regulation of 3 apoptosis genes. Conclusion: Vitamin C can protect vascular endothelial cells from mannitol-induced injury. | PAN Kai-yu SHEN Mei-ping YE Zhi-hong DAI Xiao-na SHANG Shi-qiang | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，10： | 11 |
| 12 | Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury显示文摘High mobility group box 1(HMGB1)is a ubiquitous nuclear protein that is present in almost all cells and regulates the activity of innate immune responses in both intracellular and extracellular settings.Current evidence suggests that HMGB1 plays a pivotal role in human pathological and pathophysiological processes such as the inflammatory response,immune reactions,cell migration,aging,and cell death.Sepsis is a systemic inflammatory response syndrome(SIRS)that occurs in hosts in response to microbial infections with a proven or suspected infectious etiology and is the leading cause of death in intensive care units worldwide,particularly in the aging population.Dysregulated systemic inflammation is a classic characteristic of sepsis,and suppression of HMGB1 may ameliorate inflammation and improve patient outcomes.Here,we focus on the latest breakthroughs regarding the roles of HMGB1 in sepsis and sepsis-related organ injury,the ways by which HMGB1 are released,and the signaling pathways and therapeutics associated with HMGB1.This review highlights recent advances related to HMGB1:the regulation of HMBG1 might be helpful for both basic research and drug development for the treatment of sepsis and sepsis-related organ injury. | Chao Deng Lin Zhao Zhi Yang Jia-jia Shang Chang-yu Wang Ming-zhi Shen Shuai Jiang Tian Li Wen-cheng Di Ying Chen He Li Ye-dong Cheng Yang Yang | 2022 | Acta Pharmacologica Sinica2022，43，3： | 11 |
| 13 | Development of the personalized criteria for microscopic review following four different series of hematology analyzer in a Chinese large scale hospital显示文摘 | CUI Wei WU Wei WANG Xin WANG Geng HAO Ying-ying CHEN Yu LUO Dan SHOU Wei-ling ZHANG Shuo XIANG Xue-fang SI Yong-zhen CHEN Qian CAI Hao LI Tan SHEN Han SHANG Kun ZHANG Yong-qiang | 2010 | Chinese Medical Journal2010，，22： | 10 |
| 14 | Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition)显示文摘In the early February,2020,we called up an experts' committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis,treatment and prevention of coronavirus disease 2019 (COVID-19) in children,which has been published in this journal.With accumulated experiences in the diagnosis and treatment of COVID-19 in children,we have updated the consensus statement and released the second edition recently.The current version in English is a condensed version of the second edition of consensus statement on diagnosis,treatment and prevention of COVID-19 in children.In the current version,diagnosis and treatement criteria have been optimized,and early identification of severe and critical cases is highlighted.The early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical practice.This version of experts consensus will be valuable for better prevention,diagnosis and treatment of COVID-19 in children worldwide. | Kun-Ling Shen Yong-Hong Yang Rong-Meng Jiang Tian-You Wang Dong-Chi Zhao Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Bao-Ping Xu Zheng-De Xie Zhi-sheng Liu Xing-wang Li Li-Kai Lin Yun-Xiao Shang Sai-Nan Shu Yan Bai Min Lu Gen Lu Ji-Kui Deng Wan-Jun Luo Li-Juan Xiong Miao Liu Yu-Xia Cui Le-Ping Ye Jia-Fu Li Jian-Bo Shao Li-Wei Gao Yong-Yan Wang Xue-Feng Wang | 2020 | World Journal of Pediatrics2020，16，3： | 9 |
| 15 | Synthesis and cytotoxic evaluation of new colchicine derivatives bearing 1,3,4-thiadiazole moieties显示文摘寻找新奇 anticancer 代理人,包含 1,3,4-thiadiazole 一半的一系列 N 甲基 colchiceinamide 衍生物(7a7i ) 被综合,并且他们的结构被证实由光谱分析。这些混合物的 Cytotoxicity 被 MTT 试金与四根人的肿瘤房间线在 vitro 作比较,即 A2780, A549, BEL7402,和 MCF-7。结果显示特别地,大多数衍生物显示出重要 anticancer 活动混合物 7h 和 7i 显示出更多的有势力所有屏蔽癌症房间的细胞毒素的活动比用番红花作原料而制成的植物盐基。 | Li-Hong Shen Hong-Yu Li Hui-Xia Shang Shu-Ting Tian Yi-Sheng Lai Li-Jie Liu | 2013 | Chinese Chemical Letters2013，24，4： | 7 |
| 16 | Valproic acid attenuates the multiple-organ dysfunction in a rat model of septic shock显示文摘背景 Valproic 酸(VPA ) 在一处高度致命的 poly 损伤和出血性的吃惊模型或另外的严重侮辱改进早幸存和机关功能。我们估计了 VPA 是否能在一个老鼠模型改进机关功能腐败吃惊并且说明了四十只 Sprague-Dawley 老鼠随机被分到四个组(n=10 ) 的可能的 mechanisms.Methods:控制组, VPA 组, LPS 组,和 LPS+VPA 组。Lipopolysaccharide (LPS )(10 mg/kg ) 静脉内地被注射复制试验性的模型腐败吃惊。老鼠与 VPA 被对待(300 mg/kg, i.v ) 或盐。在 LPS 注射以后的六个小时,血为煤气的分析,浆液丙氨酸 aminotransferase 的测量, aspartate aminotransferase,尿氮, creatinine 和肿瘤坏死 factor-alpha 被取样。肺,肝和肾为组织病理学说的评价被收集。另外, myeloperoxidase 活动和肿瘤坏死因素 -- 在肺的织物是在肺的 histone H3 的 measured.Acetylation 被西方的 blotting.Results LPS 也评估在 PaO2 导致了重要减少,它被 VPA 管理增加跟随的 LPS 注射。另外, LPS 也在丙氨酸 aminotransferase, aspartate aminotransferase,尿氮, creatinine,和肿瘤坏死 factor-alpha 的浆液层次导致了增加。然而,这些增加在 LPS+VPA 组被稀释。从 LPS 组的肺,肝和肾显著地与控制组相比被损坏。然而,损坏在 LPS+VPA 组被稀释。在肺的织物的 Myeloperoxidase 活动和肿瘤坏死 factor-alpha 层次与控制组相比在 LPS 组显著地增加了。这些增加显著地在 LPS+VPA 组被禁止。在在 LPS 组的肺织物的 histone H3 的 Acetylation 与控制相比被禁止。然而,在 LPS+VPA 组的 histone H3 的 acetylation 的水平显著地与有 VPA 的处理能稀释的 LPS group.Conclusions 相对照被提高导致的 LPS 引起的多重机关损坏腐败吃惊。我们的数据也建议有益的效果是部分地由于在正常 acetylation 动态平衡的煽动性的 cytokines 和恢复的减少。 | SHANG You JIANG Yuan-xu Ding Ze-jun Shen Ai-ling XU San-peng YUAN Shi-ying YAO Shang-long | 2010 | Chinese Medical Journal2010，，19： | 7 |
| 17 | Occurrence and removal of N-nitrosodimethylamine and its precursors in wastewater treatment plants in and around Shanghai显示文摘六废水处理植物(WWTP ) 被调查评估出现和移动 N-nitrosodimethylamine (NDMA ) , NDMA 形成潜力(FP ) 和四位特定的 NDMA 先锋, dimethylamine (直接存储器存取) , trimethylamine (TMA ) , dimethylformamide (DMFA ) 和 dimethylaminobenzene (DMAB ) 。与直接存储器存取功能的组一起的直接存储器存取和第三级的胺通常在市政的废水存在。化学上提高的主要过程(CEPP ) 没在 NDMA 或 NDMA FP 的移动上有效果。在有第二等的处理过程的 WWTP,可观的可变性在 NDMA (19%85%) 和 NDMA FP (16%76%) 的移动被观察,而且,在 NDMA 和 NDMA FP 的移动之间没有明确的关系。直接存储器存取很好在所有六调查 WWTP 被移开;它的移动效率比 97% 大。为第三级的胺的移动,生物学的处理与氮的硝化作用和 denitrification 处理移动效率最好比常规激活的污泥处理。为 TMA, DMFA 和 DMAB 的最好的移动效率分别地是 95% , 68% 和 72% 。CEPP 能移开 73% TMA, 23% DMFA 和 36% DMAB。在紫外消毒以后,仅仅, 17% NDMA 由于低剂量被移开紫外在 WWTP 被使用。尽管氯化能减少 NDMA 先锋, NDMA 集中实际上在氯化以后被增加。 | Lin WANG Yongmei LI Xiaoling SHANG Jing SHEN | 2014 | Frontiers of Environmental Science & Engineering2014，8，4： | 7 |
| 18 | A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland显示文摘Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children worldwide.In this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland.During November2014 to June 2016,the prospective study was conducted in 13 hospitals.The hospitalized children under 18 years old who met the criteria for CAP were enrolled.The throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay.Viral pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases.The most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south China.Human enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection.In conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP.RSV was the most important virus in hospitalized children with CAP in Chinese mainland. | Yun Zhu Baoping Xu Changchong Li Zhimin Chen Ling Cao Zhou Fu Yunxiao Shang Aihuan Chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen | 2021 | Virologica Sinica2021，36，6： | 7 |
| 19 | Prevalence of late-onset hypogonadism among middle-aged and elderly males in China:results from a national survey显示文摘This study aimed to propose an operational definition of late-onset hypogonadism(LOH)that incorporates both clinical symptoms and serum testosterone measurements to evaluate the prevalence of LOH in aging males in China.A population-based sample of 6296 men aged 40 years-79 years old was enrolled from six representative provinces in China.Serum total testosterone(TT),sex hormone-binding globulin(SHBG),and luteinizing hormone(LH)were measured and free testosterone(cFT)was calculated.The Aging Males’Symptoms(AMS)scale was used to evaluate the LOH symptoms.Finally,5078 men were included in this analysis.The TT levels did not decrease with age(P=0.59),and had no relationship with AMS symptoms(P=0.87 for AMS total score,P=0.74 for≥3 sexual symptoms).The cFT levels decreased significantly with age(P<0.01)and showed a negative association with the presence of≥3 sexual symptoms(P=0.03).The overall estimated prevalence of LOH was 7.8%(395/5078)if a cFT level<210 pmol l−1 combined with the presence of≥3 sexual symptoms was used as the criterion of LOH.Among them,26.1%(103/395)and 73.9%(292/395)had primary and secondary hypogonadism,respectively.After adjustment for confounding factors,primary and secondary hypogonadism was positively related to age and comorbidities.Body mass index was an independent risk factor for secondary hypogonadism.The results suggest that the AMS total score is not an appropriate indicator for decreased testosterone,and that the cFT level is more reliable than TT for LOH diagnosis.Secondary hypogonadism is the most common form of LOH. | Yi-Jun Liu Xu-Bo Shen Na Yu Xue-Jun Shang Yi-Qun Gu Lian-Dong Zuo Cheng-Liang Xiong Zhen Ye Yuan-Zhong Zhou | 2021 | Asian Journal of Andrology2021，23，2： | 6 |
| 20 | Simultaneous Removal of H_2S and Organosulfur Compounds from Liquefied Petroleum Gas Using Formulated Solvents: Solubility Parameter Investigation and Industrial Test显示文摘The performance of four formulated solvents(labeled as UDS-I, UDS-II, UDS-III, and UDS-IV) for removing methyl mercaptan from liquefied petroleum gas was predicted based on a two-dimensional solubility parameter theory. The calculation results show that UDS-IV has the closest solubility parameter to that of methyl mercaptan as compared with other tested solvents, indicating the strongest affinity and the highest solubility for methyl mercaptan. The industrial tests at a plant for desulfurization of LPG produced from the delayed coker have shown that the UDS solvents have the excellent performance for removal of organosulfur compounds(mainly methyl mercaptan). Although the sulfur loading dramatically increases, the total sulfur content of LPG treated with UDS-IV can be reduced by about 50% in comparison with N-methyl diethanolamine. In addition, UDS-IV has superior regeneration performance and selectivity for sulfur compounds over hydrocarbons. The industrial test and the solubility parameter calculation results are in good agreement with each other. | Zhang Feng Shen Benxian Sun Hui Liu Jichang Shang Jianfeng | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，1： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员