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| 1 | Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients显示文摘Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( P = 0.035) and sarcopenic obese( P = 0.048) patients as well as a trend favoring obese( P = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients. | Andreas Kroh Diane Uschner Toine Lodewick Roman M Eickhoff Wenzel Sch?ning Florian T Ulmer Ulf P Neumann Marcel Binneb?sel | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 5 |
| 2 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 3 | Efficient hydrolytic hydrogenation of cellulose in the presence of Ru-loaded zeolites and trace amounts of mineral acid显示文摘 | GEBOERS J VAN DE VYVER S CARPENTIER K JACOBS P SELS B | 2011 | Catal Commun2011，47，19： | 1 |
| 4 | Development of a risk tool for deliberate self-extubation in intensive care patients显示文摘 | Moons P Sels K De Becker W | 2004 | Intensive Care Med2004，30，7： | 1 |
| 5 | Development of a risk assessment tool for deliberate self-extubation in intensive care patients显示文摘 | Moons P Sels K De Becker W | | 0，，07： | 1 |
| 6 | Vitamin K status and parenteral nutrition: the effect of Intralipid on plasma vitamin KI levels显示文摘 | DRITTIJ-REIJNDERS M J SELS J P ROUFLART M | 1994 | Eur J Clin Nutr1994，48，7： | 1 |
| 7 | Monitoring of an Aeroponic Greenhouse with a Sensor Network显示文摘 | Leong B T Chan T K Sel appan P | | 0，，3： | 1 |
| 8 | Development of a risk assess- ment tool for deliberate self-extuhation in intensive care patients 显示文摘 | Moons P Sels K DeBecker W | 2004 | Intensive Care Med2004，30，7： | 1 |
| 9 | Non-alcoholic steatohepatitis:review of a growing medical problem显示文摘 | TE SLIGTE K BOURASS I SELS J P | 2004 | Eur J Intern Med2004，15，： | 1 |
| 10 | 查看详情显示文摘 | Van de Vyver S Thomas J Geboers J Keyzer S Smet M Dehaen W Jacobs P A Sels B F | | 0，，09： | 1 |
| 11 | Development of a risk tool for deliberate self-extubation in intensive care patients显示文摘 | Moons P Sels K Becker W ct al | 2004 | Intensive care medicine2004，30，7： | 1 |
| 12 | Development of a risk tool for deliberate self-extubation in intensive care patients显示文摘 | Moons P Sels K De Becker W | 2004 | Intensive Care Medicine2004，30，7： | 1 |
| 13 | Development of a risk assessment tool fol Deliberate self-extubation in intensive care patients显示文摘 | Moons P Sels K De Becker W | 2004 | Intensive Care Med2004，30，7： | 1 |
| 14 | Development of a risk tool for deliberate self- extubation in intensive carepatients显示文摘 | Moons P Sels K De Becket W | 2004 | Inten- sive Care Med2004，30，7： | 1 |
| 15 | Multi-model approach to model selection显示文摘 | Stoica P Selén Y Li J | 2004 | Digital Signal Processing2004，14，5： | 1 |
| 16 | Development of a risk tool for deliberate self--extubation in internsive care patients 显示文摘 | Moons P Sels K De Becker W | 2004 | Intensive care medicine2004，30，： | 1 |
| 17 | Development of a risk tool for deliberate self- extubation in intensive care patients 显示文摘 | Moons P Sels K De Becker W | 2004 | Intensive Care Med2004，30，7： | 1 |
| 18 | Improved blood glucose control by insulin therapy in type 2 diabetic patients has no effect on lipoprotein(a) levels显示文摘 | Wolffenbuttel BHR Leurs P Sels JPJE | 1993 | Diabet Med1993，10，： | 1 |
| 19 | Development of a risk tool for de- liberatese'-extubation in intensive care patiens 显示文摘 | Moons P Sels K De Becker W | 2004 | Intensive Care Med2004，30，7： | 1 |
| 20 | Design and application of a field mill as a high-voltage DC meter显示文摘 | Tant P Bolsens B Sel T | | 0，，04： | 1 |
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