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| 1 | 骨骼肌诱导型一氧化氮合成酶基因表达和细胞凋亡在心力衰竭进展中的作用显示文摘目的 :探讨慢性充血性心力衰竭 ( CHF)患者骨骼肌中诱导型一氧化氮合成酶 ( i NOS)基因表达与反映 CHF进展指标及细胞凋亡的关系 ,进一步了解可能影响 CHF进展的因素 ,为临床 CHF的治疗提供理论依据。方法 :用反转录多聚酶链式反应 ( RT- PCR)以及脱氧核糖核酸转化酶分析方法分别测定 2 1例 CHF患者 (扩张型心肌病 14例 ,缺血性心肌病 7例 ) ,其中 NYHA分级 级 14例 , 级 7例及 8例健康人骨骼肌标本中 i NOS基因表达和细胞凋亡 ,用心肺功能测定仪对症状限制性最大氧耗 ( VO2 max)进行连续测定。结果 :健康人骨骼肌中无i NOS基因表达及细胞凋亡 ,而 2 1例 CHF患者中有 18例 ( 85 .7% )显示 i NOS表达。 NYHA 级者 i NOS基因表达较健康者有增高趋势 ,但差异无显著性意义 ( P >0 .0 5 ) ,而 NYHA 级者 i NOS基因表达显著高于 NYHA 级 ( P <0 .0 1)。 i NOS基因表达与 VO2 max呈显著负相关 ( r =- 0 .6,P <0 .0 1)。 i NOS基因高表达 ( i NOS/GAPDH率≥ 0 .3 )患者骨骼肌细胞凋亡率高于 i NOS基因中度表达 ( i NOS/ GAPDH率 <0 .3 )患者的骨骼肌细胞凋亡率 ,P <0 .0 1。结论 :i NOS基因表达与 NYHA分级和 VO2 max显著相关 ,i NOS基因表达可反映 CHF疾病进展 ,i NOS在 | 姜红 姜波 李裕舒 Adams V Hambrecht R Schuler G | 2001 | 临床心血管病杂志2001，17，10： | 3 |
| 2 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 3 | Space durable polymeric films: Advanced materials for inflatable struc tures and thermal control Applications 显示文摘 | SCHULER P HAGHIGHAT R | 1999 | SAMPEJournal1999，5，35： | 2 |
| 4 | A Case Study of the HR Department at Swiss Bank Corporation: Customerization for Organizational Effectiveness显示文摘 | Schuler R S | 1988 | Asia Pacific Journal of Human Resources1988，26，4： | 1 |
| 5 | Technical and strategic human resource management effectiveness as determinants of finn performance显示文摘 | Huselid M A Jackson S E Schuler R S | 1997 | Academy of Management Journal1997，39，： | 1 |
| 6 | Linking Competitive Strategies with Human Resource Management Practices显示文摘 | JACKSON S E | 1987 | Academy of Management Executive1987，1，3： | 1 |
| 7 | Developmental vari- ation in cytochrome P450 expression in Papilio polyxenes in re- sponse to xanthotoxin, a hostplant allelochemicals 显示文摘 | Harrison T L Zangerl A R Schuler M A | 2001 | Archives of Insect Biochemistry Physiology2001，48，4： | 1 |
| 8 | International human resource management : a North American perspective 显示文摘 | SCHULER R S TARIQUE I | 2007 | The Inter- national Journal of Human Resource Management2007，18，5： | 1 |
| 9 | International Human Resource Management:Review and Critique显示文摘 | BUDHWAR P S FLORKOWSKI G W | 2002 | International Journal of Management Reviews2002，4，1： | 1 |
| 10 | Crystallization-induced reactions of copolymers: I , Ring-sized isomerization of poly(ester acetals)显示文摘 | Lenz R W Martin E Schuler A N | 1973 | J Polym Sci Polym Chem1973，11，： | 1 |
| 11 | Damping gimballess inertial navigation system显示文摘 | Grammatikos A Schuler A R Fegley K A | 1967 | IEEE Transactions on Aerospace and Electronic Systems1967，3，3： | 1 |
| 12 | Technical and strategic human resource effectiveness as determinants of firm performance显示文摘 | Huselid M A Jackson S E Schuler R S | | 0，，01： | 1 |
| 13 | Endothelial progenitor cells:implications for cardiovascular disease显示文摘 | MObius - Winkler S Hollriegel R Schuler G | | 0，，01： | 1 |
| 14 | Biomineralization of magnetic iron minerals in bacteria 显示文摘 | FRANKEL R B BAZYLINSKI D A SCHULER D | 1998 | Supramolecular Science1998，5，： | 1 |
| 15 | Hypersensitivity and idiosyncratic reactions to oxaliplatin 显示文摘 | Thomas R R Quinn M G Schuler B | 2003 | Cancer2003，97，9： | 1 |
| 16 | Bacterial magnetosomes: Microbiology, biomineralization and biotechnological applications 显示文摘 | SCHULER D FRANKEL R B | 1999 | Appl Microbiol Biotechnol1999，52，： | 1 |
| 17 | Determinants of Human Resource Management Priorities and Implications for Industrial Relations显示文摘 | JACKSON S E | 1989 | Journal of Management1989，15，1： | 1 |
| 18 | Linking competitive strategy and human resource management practices显示文摘 | SCHULER R S JACKSON S E | 1987 | Academy of Management Executive1987，，3： | 1 |
| 19 | Retinoblastom 显示文摘 | Bomfeld N Schuler A Boloni R | 2006 | Ophthalmology2006，103，1： | 1 |
| 20 | Regular physical exercise and low - fat diet :effects on progression of coronary artery disease显示文摘 | Schuler G Hambrecht R Schliert G | 1992 | Circulation1992，86，： | 1 |
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