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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Critical analysis of feeding jejunostomy following resection of upper gastrointestinal malignancies显示文摘AIM To assess nutritional recovery,particularly regarding feeding jejunostomy tube(FJT)utilization,following upper gastrointestinal resection for malignancy. METHODS A retrospective review was performed of a prospectively-maintained database of adult patients who underwent esophagectomy or gastrectomy(subtotal or total)for cancer with curative intent,from January 2001 to June 2014. Patient demographics,the approach to esophagectomy,the extent of gastrectomy,FJT placement and utilization at discharge,administration of parenteral nutrition(PN),and complications were evaluated. All patients were followed for at least ninety days or until death.RESULTS The 287 patients underwent upper GI resection,comprised of 182 esophagectomy(n=107 transhiatal,58.7%; n=56 Ivor-Lewis,30.7%)and 105 gastrectomy [n=63 subtotal(SG),60.0%; n=42 total(TG),40.0%]. 181 of 182 esophagectomy patients underwent FJT,compared with 47 of 105 gastrectomy patients(99.5% vs 44.8%,P < 0.0001),of whom most had undergone TG(n=39,92.9% vs n=8 SG,12.9%,P < 0.0001). Median length of stay was similar between esophagectomy and gastrectomy groups(14.7 d vs 17.1 d,P=0.076). Upon discharge,87 esophagectomy patients(48.1%)were taking enteral feeds,with 53(29.3%)fully and 34(18.8%)partially dependent. Meanwhile,20 of 39 TG patients(51.3%)were either fully(n=3,7.7%)or partially(n=17,43.6%)dependent on tube feeds,compared with 5 of 8 SG patients(10.6%),all of whom were partially dependent. Gastrectomy patients were significantly less likely to be fully dependent on tube feeds at discharge compared to esophagectomy patients(6.4% vs 29.3%,P=0.0006). PN was administered despite FJT placement more often following gastrectomy than esophagectomy(n=11,23.4% vs n=7,3.9%,P=0.0001). FJT-specific complications requiring reoperation within 30 d of resection occurred more commonly in the gastrectomy group(n=6),all after TG,compared to 1 esophagectomy patient(12.8% vs 0.6%,P=0.0003). Six of 7 patients(85.7%)who experienced tube-related complications required PN.CONCLUSION Nutritional recovery following esophagectomy and gastrectomy is distinct. Operations are associated with unique complication profiles. Nutritional supplementation alternative to jejunostomy should be considered in particular scenarios. | Andrew M Blakely Saad Ajmal Rachel E Sargent Thomas T Ng Thomas J Miner | 2017 | World Journal of Gastrointestinal Surgery2017，9，2： | 4 |
| 3 | Expression of alpha-hemoglobin stabilizing protein gene during human erythropoiesis显示文摘 | DOS SANTOS C O DUARTE A S SAAD S T | 2004 | Exp Hematol2004，32，2： | 1 |
| 4 | Polyethylene glycol 4000 attenuates adhesion formation in rats by suppression of peritoneal inflammation and collagen incorporation显示文摘 | Nagelschmidt M Minor T Saad S | 1998 | Am J Surg1998，176，： | 1 |
| 5 | High-accuracy Reference-free Ultrasonic Location Estimation 显示文摘 | Saad M M Bleakley C Ballal T | 2012 | IEEE Transaction on Instrumentation and Measurement2012，61，6： | 1 |
| 6 | Diagnostic value of HepParl, pCEA, CD10, and CD34 expression in separating hepatocellular carcinoma from metastatic carcinoma in fine-needle aspiration cytology 显示文摘 | Saad R S Luckasevic T M Noga C M | 2004 | Diagn Cytopathol2004，30，1： | 1 |
| 7 | Successful trans-plantation of porcine livers after warm ischemic insult insitu and cold preservation including postconditioning withgaseous oxygen显示文摘 | Minor T Saad S Nagelschmidt M | 1998 | Transplantation1998，65，9： | 1 |
| 8 | Extention of tolerance of pcrcine liver by cold preservation including post-conditioning with gaseous oxygen显示文摘 | Saad S Minor T Kotting M | 2001 | Transplantation2001，71，4： | 1 |
| 9 | Interleukin 1 beta and tumor necrosis factor level stored platelet concentrates and the association gene polymorphisms显示文摘 | ADDAS-CARVALHO M ORIGA A F SAAD S T | 2004 | Transfusion2004，44，： | 1 |
| 10 | Interleukin 1 beta and tumor necrosis factor levels in stored platelet concentrates and the association with gene polymorphisms 显示文摘 | Addas-Carvalh O M Origa A F Saad S T | 2004 | Transfusion2004，44，7： | 1 |
| 11 | Extension of ischemic tolerance of porcine livers by cold preservation including postconditioning with gaseous oxygen 显示文摘 | Saad S Minor T Kotting M Fu Z X | 2001 | Transplantation2001，71，4： | 1 |
| 12 | Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure 显示文摘 | Polhill T S Saad S Poronnik P | 2004 | Am J Physiol Renal Physiol2004，287，2： | 1 |
| 13 | A study comparing various noninvasive methods of detecting bladder cancer in urine显示文摘 | SAAD A HANBURY D C MCNICHOLAS T A | 2002 | BJU Int2002，89，4： | 1 |
| 14 | Polyethylene glycol 4000 attenuates adhesion formation in rats by suppression of peritoneal inflammation and collagen incorporation显示文摘 | Nagelschmidt M Minor T Saad S | | 0，，01： | 1 |
| 15 | Acute intoxica- tion of deltamethrin in monosex Nile tilapia, Oreochromis niloticus with special reference to the clinical, biochemical and haematological effects 显示文摘 | EI-Sayed Y S Saad T T E1-Bahr S M | 2007 | Environmental Toxicology and Pharmacology2007，24，： | 1 |
| 16 | Identification and sequencing of ESTs from the halophyte grass Aeluropus littoralis 显示文摘 | Zouari N Saad R B legavre T | 2007 | Gene2007，404，12： | 1 |
| 17 | Coalition formation games for collaborative spectrum sensing 显示文摘 | SAAD W HAN Z BASAR T | 2012 | IEEE Trans On Veh Technology2012，60，1： | 1 |
| 18 | Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer显示文摘 | Saad M Garbuzenko OB Minko T | 2008 | Nanomedicine (Lond)2008，3，6： | 1 |
| 19 | Response of broad bean (Vicia faba ) to method of phosphorus application and foliar application of micronutrients 显示文摘 | Thalooth A T Yakout G M Saad A O M | 2001 | Plant Nutrition2001，92，1： | 1 |
| 20 | Adap tive observers for nonlinearly parameterized class of non linear systems 显示文摘 | FARZA M M'SAAD M MAATOUG T | 2009 | Automatiea2009，45，10： | 1 |
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