|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver surgery in cirrhosis and portal hypertension显示文摘The prevalence of hepatic cirrhosis in Europe and the United States, currently 250 patients per 100000 inhabitants, is steadily increasing. Thus, we observe a significant increase in patients with cirrhosis and portal hypertension needing liver resections for primary ormetastatic lesions. However, extended liver resections in patients with underlying hepatic cirrhosis and portal hypertension still represent a medical challenge in regard to perioperative morbidity, surgical management and postoperative outcome. The Barcelona Clinic Liver Cancer classification recommends to restrict curative liver resections for hepatocellular carcinoma in cirrhotic patients to early tumor stages in patients with Child A cirrhosis not showing portal hypertension. However, during the last two decades, relevant improvements in preoperative diagnostic, perioperative hepatologic and intensive care management as well as in surgical techniques during hepatic resections have rendered even extended liver resections in higher-degree cirrhotic patients with portal hypertension possible. However, there are few standard indications for hepatic resections in cirrhotic patients and risk stratifications have to be performed in an interdisciplinary setting for each individual patient. We here review the indications, the preoperative risk-stratifications, the morbidity and the mortality of extended resections for primary and metastatic lesions in cirrhotic livers. Furthermore, we provide a review of literature on perioperative management in cirrhotic patients needing extrahepatic abdominal surgery and an overview of surgical options in the treatment of hepatic cirrhosis. | Christina Hackl Hans J Schlitt Philipp Renner Sven A Lang | 2016 | World Journal of Gastroenterology2016，22，9： | 21 |
| 2 | Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study显示文摘AIM: To prospectively analyze the impact of increased intestinal permeability(IP) on mortality and the occurrence of infections in patients with cirrhosis.METHODS: IP was quantified using the lactulose/mannitol(L/M) test in 46 hospitalized patients with cirrhosis(25 Child-Pugh A/B, 21 Child-Pugh C) and in 16 healthy controls. Markers of inflammation [LPSbinding protein, Interleukin-6(IL-6)] and enterocyte death [intestinal fatty-acid binding protein(I-FABP)] were determined in serum using enzyme-linked immunosorbent assays. Patients were followed for one year and assessed for survival, liver transplantation, the necessity of hospitalization and the occurrence of bacterial infections. The primary endpoint of the study was defined as differences in survival between patients with pathological and without pathological lactulose/mannitol test.RESULTS: Thirty-nine(85%) patients with cirrhosis had a pathologically increased IP index(L/M ratio > 0.07) compared to 4(25%) healthy controls(P < 0.0001). The IP index correlated with the ChildPugh score(r = 0.484, P = 0.001) and with serum IL-6(r = 0.342, P = 0.02). Within one year, nineteen(41%) patients developed a total of 33 episodes of hospitalization with bacterial or fungal infections. Although patients who developed spontaneous bacterial peritonitis(SBP)(n = 7) had a higher IP index than patients who did not(0.27 vs 0.14, P = 0.018), the baseline IP index did not predict time to infection, infection-free survival or overall survival, neither when assessed as linear variable, as tertiles, nor dichotomized using an established cut-off. In contrast, model for end-stage liver disease score, Child-Pugh score, the presence of ascites, serum IL-6 and I-FABP were univariate predictors of infection-free survival.CONCLUSION: Although increased IP is a frequent phenomenon in advanced cirrhosis and may predispose to SBP, it failed to predict infection-free and overall survival in this prospective cohort study. | Anika Vogt Philipp A Reuken Sven Stengel Andreas Stallmach Tony Bruns | 2016 | World Journal of Gastroenterology2016，22，11： | 8 |
| 3 | Management of syndesmotic injuries:What is the evidence?显示文摘Ankle fractures are accompanied by a syndesmotic injury in about 10% of operatively treated ankle fractures. Usually, the total rupture of the syndesmotic ligaments with an external rotation force is associated with a Weber type B or C fracture or a Maisonneuve fracture. The clinical assessment should consist of a comprehensive history including mechanism of injury followed by a specific physical examination. Radiographs, and if in doubt magnetic resonance imaging, are needed to ascertain the syndesmotic injury. In the case of operative treatment the method of fixation, the height and number of screws and the need for hardware removal are still under discussion. Furthermore, intraoperative assessment of the accuracy of reduction of the fibula in the incisura using fluoroscopy is difficult. A possible solution might be the assessment with intraoperative three-dimensional imaging. The aim of this article is to provide a current concepts review of the clinical presentation, diagnosis and treatment of syndesmotic injuries. | Marc Schnetzke Sven Y Vetter Nils Beisemann Benedict Swartman Paul A Grützner Jochen Franke | 2016 | World Journal of Orthopedics2016，7，11： | 4 |
| 4 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 5 | Radioactive tetracycline 显示文摘 | Torsten A Sven U | 1957 | J Am Chem Soc1957，79，2： | 1 |
| 6 | The role of market orientation and entrepreneurial orientation for new production development performance in manufacturing firms显示文摘 | JOHAN F SVEN A H | 2007 | Technology Analysis&Strategic Management2007，，11： | 1 |
| 7 | New developments in the diagnosis of bloodstream infections显示文摘 | Remco P H Peters Michiel A van Agtmael Sven A Danner | 2004 | Infectious Diseases2004，4，12： | 1 |
| 8 | The effect of the quadratic gradient term on variable-rate well tests显示文摘 | Braeuning S Jelmert T A Sven A V | 1998 | Journal of Petroleum Science and Engineering1998，21，2： | 1 |
| 9 | A role for the human NLR family member NLRC5 in antiviral responses 显示文摘 | Sven K Andreas T Menning et a/ | 2010 | J Biol Chem2010，285，26： | 1 |
| 10 | Concise stereo controlled mutes to fumagillol,fumagillin and TNP-470显示文摘 | DAVID A VOSBURGM SVEN WEILER | 2003 | Chirality2003，15，： | 1 |
| 11 | An improvement of the aluminium iodide method for ether cleavage: catalysis by quatermary ammonium iodide 显示文摘 | Sven A | 1985 | Synthesis1985，4，： | 1 |
| 12 | Approximate optimization of a two-level distribution inventory system显示文摘 | SVEN A | | 0，，： | 1 |
| 13 | The sensitivity and specificity of nonmydriatic digital stereoscopic retinal Imagine in detecting diabetic retinopathy显示文摘 | JEHANARA A THOMAS P SVEN ERIC B | 2006 | Diabetes Care2006，29，10： | 1 |
| 14 | Risk factors for acute re- spiratory morbidity in moderately preterm infants 显示文摘 | Maria A Mireille V Sven C | 2013 | Paediatr Perinat Epidemiol2013，27，2： | 1 |
| 15 | Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model显示文摘 | SVEN A LANG ANDREAS GAUMANN GUDRUN E KOEHL | | 0，，： | 1 |
| 16 | Precision calorimetry for the accurate measurement of Losses in Power Electronic Devices显示文摘 | Weier Sven Shaft Mohsin A McMahon Richard | 2010 | IEEE Transactions on Industry Applications2010，46，1： | 1 |
| 17 | Genonae sequence of the arctic methaaotroph Methylobacter tundripaludum SV96显示文摘 | Svenning M M Hestnes A G Wartiainen I | 2011 | Journal of Bacteriology2011，193，： | 1 |
| 18 | Analyzing the functional dynamics of technological innovation systems : a scheme of analysis 显示文摘 | Bergek A Staffan Jacobsson Bo Carlsson Sven Lind- mark Annika Rickne | 2008 | Research Policy2008，37，： | 1 |
| 19 | A Pilot Evaluation of Car Seat Side Support: Leading to a Redefinition of the Problem显示文摘 | Denis A Coelho Sven Dahlman | 1999 | International Journal of Industrial Ergonomics1999，24，2： | 1 |
| 20 | The effect of the quadratic gradient term on various welltests 显示文摘 | BRAEUNING S JELMERT T A SVEN A V | 1998 | Journal of Petroleum Science and Engineering1998，21，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员