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| 1 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 2 | Cerebral autoregulation in patients with end-stage liver disease显示文摘 | Strauss GI Hansen BA Herzog T | 2000 | Eur J Gastroenterol Hepatol2000，12，7： | 1 |
| 3 | Processing of the envelope glycoproteins of pestviruses 显示文摘 | Rumenapf T Unger G Strauss J H | 1993 | J Virol1993，67，6： | 1 |
| 4 | Mechanical/thermal de- watering-a new process for the utilisation of ligite for power generation显示文摘 | Strauss K Bergins C Wild T | 2006 | Fuel2006，，2： | 1 |
| 5 | The miRNA path- way intrinsically controls self-renewal of Drosophila germline stem cells 显示文摘 | Park J K Liu X Strauss T J | 2007 | Ctrr Biol2007，17，： | 1 |
| 6 | Animia in cervical cancers: impact on survival, patterns of relapse, and association with hypoxia and angiogenesis 显示文摘 | Dunst J Kuhnt T Strauss HG | 2003 | Int Radiat Oncol Biol Phys2003，56，3： | 1 |
| 7 | C3 nephritic factor and hypocomplementaemia in a clinically healthy individual显示文摘 | Gewurz A T Imherr S M Strauss S | 1983 | Clin Exp Immunol1983，54，1： | 1 |
| 8 | Sonographic feature of horseshoe kidney:review of 34 patients显示文摘 | Strauss S Dushnitsky T Peer A | 2000 | J Uhras Med2000，19，1： | 1 |
| 9 | The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cells 显示文摘 | PARK J K LIU X STRAUSS T J | 2007 | Current Biology2007，17，6： | 1 |
| 10 | Computed tomography versus watersolube contrast swallow in the detectionof intra thoracic anastomotic leak complicating esophagogastrectomy (IvorLewis): a prospective study in 97patients 显示文摘 | Strauss C Mal F Pemiceni T | 2011 | Ann Surg2011，251，4： | 1 |
| 11 | Insights from stable S and O isotopes into biogeochemical processes and genesis of Lower Cambrian barite-pyrite concretions of South China显示文摘 | Goldberg T Mazumdar A Strauss H | 2006 | Organic Geochemistry2006，37，10： | 1 |
| 12 | Surgical management of meniscal tears显示文摘 | Shybut T Strauss EJ | 2011 | Bull NYU Hosp Jt Dis2011，69，1： | 1 |
| 13 | Biocatalytic transformation of racemates into chiral building blocks in 100% chemical yield and 100% enantiomeric excess 显示文摘 | Strauss U T Faber U Felferand K | 1999 | Tetrahedron : Asymmetry1999，10，1： | 1 |
| 14 | Agrobacterium mediated transformation of hybrid poplar suspension cultures and regeneration of transformed plants显示文摘 | Howe G T Goldfarb B Strauss S H | 1994 | Plant Cell Tiss Organ Cult1994，36，： | 1 |
| 15 | Neonatal IVH- mechanisms and management 显示文摘 | Kenet G Kuperman A A Strauss T | 2011 | Thromb Res2011，127，3： | 1 |
| 16 | Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis显示文摘 | Lin D Sugawara T Strauss JF 3rd | 1995 | Science1995，267，： | 1 |
| 17 | Reconstructing marine redox conditions for the Early Cambrian Yangtze Platform: Evidence from biogenic sulphur and organic carbon isotopes 显示文摘 | Goldberg T Strauss H Guo Q J Liu C Q | 2007 | Palaeogeogr Palaeoclimatol Palaeoecol2007，254，12： | 1 |
| 18 | Prevalence and clinical impact of left atrial thrombus and dense spontaneous echo contrast in patients with atrial fibrillation and low CHADS2 score 显示文摘 | Kleemann T Becker T Strauss M | 2009 | Eur J Echocardiogr2009，10，3： | 1 |
| 19 | Expression of ICOS on human melanoma-infiltrating CD4(+)CD25highFoxp3(+) T regulatory cells:implications and impact on tumor-mediated immune suppression显示文摘 | Strauss L Bergmann C Szczepanski M J Lang S Kirkwood J M Whiteside T L | 2008 | J Immunol2008，180，： | 1 |
| 20 | ^87Sr/^86Sr, δ^13C and δ^18O evolution of Phanerozoic seawater 显示文摘 | Veizer J Ala D Azmy K Bruckschen P Buhl D Bruhn F Carden G A F Diener A Ebneth S Godderis Y Jasper T Korte C Pawellek F Podlaha O G Strauss H | 1999 | Chem Geol1999，161，13： | 1 |
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