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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Determination of pyrazine and flavor variations inpeanutgenotypes during roasting显示文摘 | Baker G L Cornell J A Gorbet D W Okeefe S F Sims C A Talcott ST | 2003 | Journal of Food Science2003，68，1： | 1 |
| 3 | Association within a family of a balanced autosomal translocation with major mental illness显示文摘 | St Clair D Blackwood D Muir W Carothers A Walker M Spowart G Gosden C Evans H J | | 0，，8706： | 1 |
| 4 | the Anodic dissolution of magnesium in chloride and sulphate solutions显示文摘 | SONG G ATRENS A ST JOHN D WU X NAIRN J | 1997 | Corrosion Science1997，39，1011： | 1 |
| 5 | Functional analysis and chromosomal mapping of Gata5,a gene encoding a zinc finger DNA-binding protein显示文摘 | Nemer G Qureshi ST Malo D | 1999 | Mamm Genome1999，10，10： | 1 |
| 6 | Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon inducible immunoproteasome 显示文摘 | Yang Z Gagarin D St Laurent G | 2009 | Arterioscler ThrombVascBiol2009，29，8： | 1 |
| 7 | Corrosion resistance of aged die cast magnesium alloy AZ91D显示文摘 | SONG G L BOWLES A L JOHN D H ST | 2004 | Materials Science and Engineering2004，366，： | 1 |
| 8 | Factors influencing condom use among Af- rican American women: implications for risk reduction inter- ventions显示文摘 | St Lawrence J S Eldridge G D Reitman D Little C E Shelby M C Brasfield T L | 1998 | Am J Community Psychol1998，26，： | 1 |
| 9 | Allelic variation of human serotonin transporter gene expression显示文摘 | Heils A Teufel A Petri S St(o)ber G Riederer P Bengel D & Lesch K.P | | 0，，06： | 1 |
| 10 | Clinicopathological study of seven cases of spinal cord teratoma: a possible germ cell origin 显示文摘 | Parmar D Dean AF Phookun G Bridges LR | 1998 | Histopathology1998，32，1： | 1 |
| 11 | Microporosity formation in Al-Si-Cu-Mg casting alloys 显示文摘 | Sigworth G K Caceres C H St John D H Barresi J | 1997 | AFS Trans1997，105，： | 1 |
| 12 | Antigenic and genetic char- acteristics of swine - origin 2009 A( H1N1 ) influenza viruses cir- culating in humans 显示文摘 | Garten R J Davis C T Russell C A Shu B Lindstrom S Balish A Sessions W M Xu X Skepner E Deyde V Okomo - Adhi- ambo M Gubareva L Barnes J Smith C B Emery S L Hillman M J Rivailler P Smagala J de Graaf M Burke D F Fouchier R A Pappas E Alpuche - Aranda C M Lopez - Gatell H Ohvera H Lopez I Myers C A Faix D Blair P J Yu C Keene K M Dotson P D Jr Boxrud D Sambol A R Abid S H St George K Bannerman T Moore A L Stringer D J Blevins P Demmler - Harrison G J Ginsberg M Kriner P Waterman S Smole S Guevara H F Belongia E A Clark P A Beatrice S T Donis R Katz J Finelli L Bridges C B Shaw M Jernigan D B Uyeki T M Smith D J Klimov A I Cox N J | 2009 | Science2009，325，5937： | 1 |
| 13 | The role of iron in the formation of porosity in Al-Si-Cu-base casting alloys 显示文摘 | Schaffer G B St John D H | 1999 | Metall Mater Trans1999，30，： | 1 |
| 14 | Soil-landscape analysis in relation to soil distribution and mapping at a site within the Weyburn Association显示文摘 | King G J Acton D F Arnaud R J St | 1983 | Canadian Journal of Soil Science1983，63，4： | 1 |
| 15 | Normal Laparo scopic Anatomy of the Bovine Abodomen 显示文摘 | Anderson D E Gaughan E M St Jean G | 1993 | Am J Vet Res1993，54，： | 1 |
| 16 | Neonatal gastrointestinal perorations 显示文摘 | St Vif D Lebouthiffier G Lujks FI | 1992 | J Pediatri Surg1992，27，10： | 1 |
| 17 | The anodic dissolution of magnesium in chloride and sulphate solutions显示文摘 | SONG G ATRENS A ST John D | 1997 | Corrosion Science1997，39，1011： | 1 |
| 18 | Synthesis and comparative biodegradability studies of three poly(alkylene succinate)s显示文摘 | Bikiaris D N Papageorgiou G Z Achilias D S st al | 2006 | Polym Degrad and Stab2006，91，1： | 1 |
| 19 | Corrosion behavior of magnesium in ethylene glycol显示文摘 | SONG G ST JOHN D | 2004 | Corrosion Science2004，46，： | 1 |
| 20 | The anodic dissolutionof magnesium in chloride and sulphate solutions 显示文摘 | Song G Atrens A St John D | 1997 | Corrosion Science1997，39，1011： | 1 |
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