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| 1 | Mnk kinase pathway: Cellular functions and biological outcomes显示文摘The mitogen-activated protein kinase(MAPK) interacting protein kinases 1 and 2(Mnk1 and Mnk2) play important roles in controlling signals involved in mRNA translation. In addition to the MAPKs(p38 or Erk), multiple studies suggest that the Mnk kinases can be regulated by other known kinases such as Pak2 and/or other unidentified kinases by phosphorylation of residues distinct from the sites phosphorylated by the MAPKs. Several studies have established multiple Mnk protein targets, including PSF, heterogenous nuclear ribonucleoprotein A1, Sprouty 2 and have lead to the identification of distinct biological functions and substrate specificity for the Mnk kinases. In this review we discuss the pathways regulating the Mnk kinases, their known substrates as well as the functional consequences of engagement of pathways controlled by Mnk kinases. These kinases play an important role in mRNA translation via their regulation of eukaryotic initiation factor 4E(eIF4E) and their functions have important implications in tumor biology as well as the regulation of drug resistance to anti-oncogenic therapies. Other studies have identified a role for the Mnk kinases in cap-independent mRNA translation, suggesting that the Mnk kinases can exert important functional effects independently of the phosphorylation of eIF4 E. The role of Mnk kinases in inflammation and inflammationinduced malignancies is also discussed. | Sonali Joshi Leonidas C Platanias | 2014 | World Journal of Biological Chemistry2014，5，3： | 16 |
| 2 | Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection显示文摘AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis. | HMC Shantha Kumara David Gaita Hiromichi Miyagaki Xiaohong Yan Sonali AC Hearth Linda Njoh Vesna Cekic Richard L Whelan | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 4 |
| 3 | Thrombocytopenia in cirrhosis:Impact of fibrinogen on bleeding risk显示文摘AIM To investigate the relationship between baseline platelet count,clauss fibrinogen,maximum amplitude(MA) on thromboelastography,and blood loss in orthotopic liver transplantation(OLT).METHODS A retrospective analysis of our OLT Database(2006-2015) was performed.Baseline haematological indices and intraoperative blood transfusion requirements,as a combination of cell salvage return and estimation of 300 mls/unit of allogenic blood,was noted as a surrogate for intraoperative bleeding.Two groups:Excessive transfusion(>1200 mL returned) and No excessive transfusion(<1200 m L returned) were analysed.All data analyses were conducted using IBM SPSS Statistics version 23.RESULTS Of 322 OLT patients,77 were excluded due to fulminant disease;redo transplant or baseline haemoglobin(Hb) of<80 g/L.One hundred and fourteen(46.3%) were classified into the excessive transfusion group,132(53.7%) in the no excessive transfusion group.Mean age and gender distribution were similar in both groups.Baseline Hb(P≤0.001),platelet count(P=0.005),clauss fibrinogen(P=0.004) and heparinase MA(P=0.001) were all statistically significantly different.Univariate logistic regression with a cut-off of platelets<50×10~9/L as the predictor and Haemorrhage as the outcome showed an odds ratio of 1.393(95%CI:0.758-2.563;P=0.286).Review of receiver operating characteristic curves showed an area under the curve(AUC) for platelet count of 0.604(95%CI:0.534-0.675;P=0.005) as compared with AUC for fibrinogen level,0.678(95%CI:0.612-0.744;P≤0.001).A multivariate logistic regression shows United Kingdom model for End Stage Liver Disease(P=0.006),Hb(P=0.022) and Fibrinogen(P=0.026) to be statistically significant,whereas Platelet count was not statistically significant.CONCLUSION Platelet count alone does not predict excessive transfusion.Additional investigations,e.g.,clauss fibrinogen and viscoelastic tests,provide more robust assessment of bleeding-risk in thrombocytopenia and cirrhosis. | Sonali V Thakrar Susan V Mallett | 2017 | World Journal of Hepatology2017，9，6： | 4 |
| 4 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 5 | Review of current progress in hole-transporting materials for perovskite solar cells显示文摘Recent advancements in perovskites’ application as a solar energy harvester have been astonishing. The power conversion efficiency(PCE) of perovskite solar cells(PSCs) is currently reaching parity(>25 percent), an accomplishment attained over past decades. PSCs are seen as perovskites sandwiched between an electron transporting material(ETM) and a hole transporting material(HTM). As a primary component of PSCs, HTM has been shown to have a considerable effect on solar energy harvesting, carrier extraction and transport, crystallization of perovskite, stability, and price. In PSCs, it is still necessary to use a HTM.While perovskites are capable of conducting holes, they are present in trace amounts, necessitating the use of an HTM layer for efficient charge extraction. In this review, we provide an understanding of the significant forms of HTM accessible(inorganic, polymeric and small molecule-based HTMs), to motivate further research and development of such materials. The identification of additional criteria suggests a significant challenge to high stability and affordability in PSC. | Prerna Mahajan Bhavya Padha Sonali Verma Vinay Gupta Ram Datt Wing Chung Tsoi Soumitra Satapathi Sandeep Arya | 2022 | Journal of Energy Chemistry2022，31，5： | 3 |
| 6 | Discovery and preclinical development of ⅢM-160, a Bergenia ciliatabased anti-inflammatory and anti-arthritic botanical drug candidate显示文摘Objective: Bergenia ciliata(Haw.) Sternb. is used in the Indian traditional system of medicine to treat various ailments including rheumatism and to heal wounds. The objective of the present study was to perform a preclinical characterization of the B. ciliata-based botanical extract IIIM-160.Methods: ⅢM-160 was chemically standardized and analyzed for heavy metal content, aflatoxins,pesticides and microbial load. The in vitro and in vivo efficacies were determined in suitable models of inflammation, arthritis and nociception. An acute oral toxicity study was performed in Swiss albino mice.A suitable oral formulation was developed and characterized.Results: Bergenin was found to be the major component(9.1% w/w) of ⅢM-160. The botanical lead displayed inhibition of lipopolysaccharide-induced production of proinflammatory cytokines in THP-1 cells, with selectivity toward interleukin-6(IL-6) and had an excellent safety-window. It showed anti-inflammatory, anti-arthritic and antinociceptive activity in animal models and was not toxic at oral doses up to 2 g/kg in Swiss-albino mice. The gastroretentive, sustained-release capsule formulation showed sustained-release of the bergenin over the period of 24 h, resulting in improved plasma-exposure of bergenin in Sprague–Dawley rats.Conclusion: The dual-activity of IL-6 inhibition and antinociception marks the suitability of ⅢM-160 for treating rheumatoid arthritis. This study will serve as the benchmark for further research on this botanical formulation. | Sandip B.Bharate Vikas Kumar Sonali S.Bharate Bikarma Singh Gurdarshan Singh Amarinder Singh Mehak Gupta Deepika Singh Ajay Kumar Surjeet Singh Ram A.Vishwakarma | 2019 | Journal of Integrative Medicine2019，17，3： | 3 |
| 7 | Metabolic bariatric surgery and type 2 diabetes mellitus:an endocrinologist's perspective显示文摘Traditional treatment of T2 DM consisting of modification of diet,an exercise regimen,and pharmacotherapy has problems of poor lifestyle modifications and fail tend of treatment over time,now bariatric surgery is recommended for treatment of obese patients with T2 DM because its great improvements on weight loss and metabolic.In this article,effects of bariatric surgery on diabetes and diabetes-related complications are reviewed. | Sonali Ganguly Hong Chang Tan Phong Ching Lee Kwang Wei Tham | 2015 | The Journal of Biomedical Research2015，29，2： | 3 |
| 8 | Viral hepatitis:Past,present,and future显示文摘Each hepatitis virus—Hepatitis A,B,C,D,E,and G—poses a distinct scenario to the patient and clinician alike.Since the discovery of each virus,extensive knowledge regarding epidemiology,virologic properties,and the natural clinical and immunologic history of acute and chronic infections has been generated.Basic discoveries about host immunologic responses to acute and chronic viral infections,combined with virologic data,has led to vaccines to prevent Hepatitis A,B,and E and highly efficacious antivirals for Hepatitis B and C.These therapeutic breakthroughs are transforming the fields of hepatology,transplant medicine in general,and public and global health.Most notably,there is even an ambitious global effort to eliminate chronic viral hepatitis within the next decade.While attainable,there are many barriers to this goal that are being actively investigated in basic and clinical labs on the local,national,and international scales.Herein,we discuss pertinent clinical information and recent organizational guidelines for each of the individual hepatitis viruses while also synthesizing this information with the latest research to focus on exciting future directions for each virus. | Matthew August Odenwald Sonali Paul | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 9 | Validity of subjective assessment as screening tool for dry eye disease and its association with clinical tests显示文摘AIM: To determine the role of subjective assessment using Mc Monnies dry eye questionnaire in diagnosing dry eye disease and its association with clinical tests.METHODS: There were 500 patients screened for dry eye using Mc Monnies dry eye questionnaire between May to October 2013 at the outpatient Department of Ophthalmology of a medical college hospital. All 500 patients were subjected to clinical tests. Dry eye was defined as having one or more symptoms often or all the time. Positive signs were if one or both eyes revealed tear film breakup time(TBUT) of ≤10s, a Schirmer test score of ≤10 mm, a Rose Bengal staining score of ≥1, a Lissamine green staining score of ≥1 or existence of meibomian gland disease(≥grade 1). Statistical analysis was performed to describe the distribution of symptoms and signs, to assess the correlations between Mc Monnies score(MS) and variable clinical signs of dry eye, and to explore the association between dry eye symptoms and variable clinical signs. Analysis was performed using software package Epi info. A Probability(P) value using Chi-square test of <0.005 was taken as significant.· RESULTS: Dry eye prevalence with symptoms(questionnaire), Schirmer test, TBUT, Rose Bengal staining and Lissamine green staining was 25.6%,15.20%, 20.80%, 23.60%, and 22.60% respectively. Among those with severe symptoms(MS>20), 75.86% had a low TBUT(<10s), 58.62% had a low Schirmer's I test(≤10 mm),86.20% had Rose Bengal staining score of ≥1, 79.31%had Lissamine green staining score of ≥1. We found statistically significant associations between positive Schirmer test and arthritis(P <0.002), dryness elsewhere(P <0.001), contact lens use(P < 0.002), systemic medication(P <0.0001), sleeping with eyes partly open(P <0.002), history of dry eyes treatment(P <0.0001),environmental factors(P <0.001), swimming(P <0.001).· CONCLUSION: Subjective assessment plays an important role in diagnosing dry eye disease. There is strong correlation between MS and Schirmer test, TBUT,Rose Bengal staining and Lissamine green staining in normal as well as marginal and pathological dry eye. | Kavita R Bhatnagar Sonali Pote Sudeep Pujari Dhiraj Deka | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 2 |
| 10 | River Rafting in Mountainous Regions of Uttarakhand:Impacts,Suggested Mitigation Measures and Sustainability显示文摘Uttarakhand state in India is well known for its mountainous ecosystems,traditional communities and a variety of ecotourism destinations.Among various tourism activities,River Rafting along the banks of the Ganges River has increased tremendously for two decades,and has had unprecedented impacts on the traditional communities and the bio-diversity.Therefore,it is meaningful to do a comprehensive study on the various impacts associated with river rafting so as to suggest the pathways to achieve the environmental sustainability in this region.In this study,we collected primary data from randomly selected population units across all stake holders such as local people(n = 100),and camp personnel(n = 22),through a pre-tested questionnaire survey between August 2009 and May 2010.The questionnaire contains issues on culture,social,economic,institutional and associated perceived impacts on pollution and biodiversity including views for sustainability.Secondary information was also collected from various sources and government records to supplement and strengthen the analysis.The impacts were analyzed qualitatively through a ranking mechanism to facilitate the decision making process.The perception of the interviewee about the various possible impacts of rafting was discussed with mitigating mechanism.The ranking analysis as percollected data reveals that economy and education of local community was improved significantly;however aquatic and terrestrial fauna,social cohesion and pollution(water,air,land) were significantly deteriorated.The results show that the existing practices are not sufficient to address the adverse impacts.Improvement in practices is necessary,mainly in the policy regime.Based on the analysis,some measures are recommended on how to protect community interest and environment with the development of river rafting as an ecotourism opportunity. | Parth Sarathi MAHAPATRA Rajiv PANDEY Sonali PRADHAN | 2012 | Journal of Mountain Science2012，9，4： | 2 |
| 11 | Flood susceptibility modelling using advanced ensemble machine learning models显示文摘Floods are one of nature's most destructive disasters because of the immense damage to land,buildings,and human fatalities.It is difficult to forecast the areas that are vulnerable to flash flooding due to the dynamic and complex nature of the flash floods.Therefore,earlier identification of flash flood susceptible sites can be performed using advanced machine learning models for managing flood disasters.In this study,we applied and assessed two new hybrid ensemble models,namely Dagging and Random Subspace(RS)coupled with Artificial Neural Network(ANN),Random Forest(RF),and Support Vector Machine(SVM)which are the other three state-of-the-art machine learning models for modelling flood susceptibility maps at the Teesta River basin,the northern region of Bangladesh.The application of these models includes twelve flood influencing factors with 413 current and former flooding points,which were transferred in a GIS environment.The information gain ratio,the multicollinearity diagnostics tests were employed to determine the association between the occurrences and flood influential factors.For the validation and the comparison of these models,for the ability to predict the statistical appraisal measures such as Freidman,Wilcoxon signed-rank,and t-paired tests and Receiver Operating Characteristic Curve(ROC)were employed.The value of the Area Under the Curve(AUC)of ROC was above 0.80 for all models.For flood susceptibility modelling,the Dagging model performs superior,followed by RF,the ANN,the SVM,and the RS,then the several benchmark models.The approach and solution-oriented outcomes outlined in this paper will assist state and local authorities as well as policy makers in reducing flood-related threats and will also assist in the implementation of effective mitigation strategies to mitigate future damage. | Abu Reza Md Towfiqul Islam Swapan Talukdar Susanta Mahato Sonali Kundu Kutub Uddin Eibek Quoc Bao Pham Alban Kuriqi Nguyen Thi Thuy Linh | 2021 | Geoscience Frontiers2021，12，3： | 2 |
| 12 | In vivo antianxiety and antidepressant activity of Murraya paniculata leaf extracts显示文摘OBJECTIVE: Different parts of Murraya paniculata have been used traditionally for treating several ailments including mental disorders. The present study was designed to evaluate the antianxiety and antidepressant potential of M. paniculata leaves using elevated plus maze model and forced swim test, respectively.METHODS: Extracts of M. paniculata made with petroleum ether(60–80 °C), chloroform, ethanol and water were evaluated for antianxiety and antidepressant activity. The anxiolytic chloroform extract was subjected to column chromatography, yielding five fractions(F_1–F_5). Fraction F_5(100 mg/kg), which showed notable anxiolytic activity, was further chromatographed to get four subfractions(F_(5.1)–F_(5.4)). Simultaneously, the ethanol extract was partitioned with ethyl acetate to obtain ethyl acetate soluble fraction(EASF) and ethyl acetate insoluble fraction. Phytochemical screening of bioactive extracts/fractions and detection of mahanimbine in M. paniculata leaf extract by thin-layer chromatography was also carried out.RESULTS: Fraction F_(5.3)(25 mg/kg) and EASF(20 mg/kg) showed significant anxiolytic and antidepressant activity, respectively. Thin-layer chromatography and phytochemical screening demonstrated the absence of mahanimbine in M. paniculata leaves. Coumarins were observed to be responsible for the anxiolytic activity.CONCLUSION: The results validate the traditional use of M. paniculata leaves in the treatment of mental disorders. | Pragya Sharma Sonali Batra Ashwani Kumar Anupam Sharma | 2017 | Journal of Integrative Medicine2017，15，4： | 2 |
| 13 | Effect of cytokinins on in vitro multiplication of Sophora tonkinensis显示文摘Objective:To determine the effects of different cytokinins at various concentrations onin vitro shoot multiplication of an important medicinal plant.Methods:Nodal explants(1.5-2.0 cm)of Sophora tonkinensiswere used.Multiple shoots were induced from nodal explants cultured onthe Murashige and Skoog(MS)medium supplemented with 0.0,0.5,1.0,2.0,4.0,8.0,or 16.0μmol2-isopentyladenine(2iP),N6 benzyladenine,kinetin or thiadiazuron.Results:Among the fourinvestigated cytokinins,2iP showed the best response for shoot multiplication.Maximum shootinduction(75%)was achieved on the MS medium supplemented with 2.0μmol 2iP,with a meannumber of 5.0 shoots per explant.In comparison to other cytokinins tried,2iP showed the highestshoot elongation with a mean shoot length of 4.8 cm.Root initiation was observed within 15 dwithin the transfer of shoots onto the MS basal medium,and the rooting percentage was 100%with a mean number of 5.4 roots per shoot and root length of 6.2 cm over a period of 4 weeks.Thehealthy plants,hardened and transferred to a greenhouse for proper acclimatization,exhibited100%survival.Conclusions:It can be summarized that 2iP is the optimal plant growth regulatorforSophoramultiplication. | Sonali Jana Iyyakkannu Sivanesan Byoung Ryong Jeong | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，7： | 2 |
| 14 | 浸渍硅胶薄层色谱板分离钴和镍及数字图像分析法定量(英文)显示文摘Thin layer chromatography(TLC) of cobalt and nickel has been performed on silica gel layers induced with alkali mediated cellulose extract.A novel combination of 10% aqueous solutions of Tween-20 and potassium thiocyanate in 1∶1(v/v) was identified as the best mobile phase for the selective separation of Co2+from Ni2+on the impregnated Silica Gel G layers.The chromatographic characteristics of the cations were studied and the limits of detection as well as the limits of quantification for Co2+and Ni2+were determined.The quantitative estimation of the cations was achieved from the digital image analysis of respective chromatograms.The proposed quantitative method was successfully applied with 0-0.50% error for the determination of Co2+from Ni2+in spiked samples of bauxite,soil and rock containing common cations such as Al3+,Fe2+,Ti4+,Zn2+,Mn2+,Cu2+,Cr6+,Mg2+,etc.under the optimized chromatographic conditions. | P A MOHAMED NAJAR R G SONALI M T NIMJE K V RAMANA RAO | 2012 | 色谱2012，30，10： | 2 |
| 15 | Er^(3+)-Yb^(3+)-Na^(+):ZnWO_(4) phosphors for enhanced visible upconversion and temperature sensing applications显示文摘The crystal structure and surface morphology of the Er^(3+)/Yb^(3+)/Na+:ZnWO_(4) phosphors synthesized by solid state reaction method were analyzed by X-ray diffraction(XRD) and field emission scanning electron microscopy(FESEM) analysis.The frequency upconversion(UC) emission study in the developed phosphors was investigated by using 980 nm laser diode excitation.The effect of codoping in the Er^(3+):ZnWO_(4) phosphors on the UC emission intensity was studied.The UC emission bands that are exhibited in the blue(490 nm),green(530,552 nm),red(668 nm) and NIR(800 nm) region correspond to the ^(4)F_(7/2)→^(4)I_(15/2).^(2)H_(11/2),^(4)S_(3/2)→^(4)I_(15/2),^(4)F_(9/2)→^(4)I_(15/2) and ^(4)I9/2→^(4)I_(15/2) transitions,respectively.The temperature sensing performance of the Er^(3+)-Yb^(3+)-Na+:ZnWO_(4) phosphors was investigated based on the 2 H_(11/2)→^(4)I_(15/2) and ^(4)S_(3/2)→^(4)I_(15/2) thermally coupled transitions of the Er^(3+)ions.The photometric study was also carried out for the developed phosphors. | Sonali Biswas Lakshmi Mukhopadhyay Manisha Mondal Vineet Kumar Rai | 2021 | Journal of Rare Earths2021，39，3： | 1 |
| 16 | Cone-Beam CT Diagnostic Applications: Caries, Periodontal Bone Assessment, and Endodontic Applications显示文摘 | Donald A. Tyndall Sonali Rathore | 2008 | Dental Clinics of North America2008，，4： | 1 |
| 17 | Ewing’s sarcoma of primitive neuroectodermal tumour of cervix: a case report 显示文摘 | Sonali D Kanan Y | 2014 | J Evolution Med Dental Sci2014，3，1： | 1 |
| 18 | Electronic Structure,Chemical Bonding,and Optical Properties of Paraelectric BaTiO3显示文摘 | SAHA SONALI SINHA T P MOOKERJEE ABHIJIT | 2000 | Physical Review B2000，62，： | 1 |
| 19 | Cone-Beam CT Diagnostic Applications: Caries, Periodontal Bone Assessment, and Endodontic Applications显示文摘 | Donald A. Tyndall Sonali Rathore | 2008 | Dental Clinics of North America2008，，4： | 1 |
| 20 | Antiulcer effect of mammalian lignan precursors from flaxseed 显示文摘 | Sonali Joshi Sagar Mandawgade Vinam Mehta Sadhana Sathaye | 2008 | Informa Healthcare2008，46，5： | 1 |
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