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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | 中加合作农业生态学“双语+精品”课程建设的探索与实践显示文摘在国际教育合作背景下,福建农林大学引进的农业生态学(Agroecology)课程与福建省甚至全国高校双语课程相比具有独特的优势。本文回顾了中加合作《农业生态学》双语课程的引进和适应过程,以及其作为福建省'精品课程'的教学体系、风格、方式及其建设成效;最后作者提出从促进国际交流、加强教材建设和教学成果的推广应用等3方面努力把该课程建成国家级'双语示范课程'。 | 王松良 Claude D Caldwell Shannon Kilyanek 林德喜 魏丽卿 | 2010 | 福建农林大学学报(哲学社会科学版)2010，13，1： | 12 |
| 3 | Client-level predictors of treatment engagement,outcome and dropout:moving beyond demographics显示文摘Background Despite the availability of evidence-based treatments for posttraumatic stress disorder(PTSD),significant heterogeneity in the effectiveness of PTSD treatment persists,especially in community settings.Client demographics used to understand this variability in treatment outcome and dropout have yielded mixed results.Despite increasing evidence for the importance of attending to treatment engagement in community settings,few studies have explored client-level predictors.Aim The purpose of this study is to explore client-level predictors of treatment outcome and dropout beyond client demographics,and to identify client-level predictors of treatment engagement in community settings.Method Secondary data analysis was conducted with data collected as part of an implementation-effectiveness hybrid study of cognitive processing therapy(CPT)for PTSD in a diverse community healthcentre.Providers(n=19)treated(n=52)clients as part of their routine clinical care.Non-demographic client-level predictors included barriers to treatment,quality of life,session-level language and employment history assessed at baseline.Treatment engagement included number of weeks in the study,number of sessions with repeated CPT content,number of unique CPT sessions attended,frequency of session attendance and consistency of session attendance.Results Results showed language as a significant predictor of treatment engagement.There were significant differences between Spanish and English-speaking clients,with the former having a tendency to repeat more session content than the latter(β=1.4 sessions,p=0.003),and also less likely to attend treatment frequently(r=0.62,p=0.009)and consistently(r=0.57,p=0.027)if high logistical and financial barriers were endorsed.Irrespective of language,clients who reported high quality of life at baseline were less likely to repeat CPT session content(β=-0.3,p=0.04),and those with increased baseline barriers to treatment had deceleration in PTSD symptom improvement over time(β=-0.62,p<0.05).In terms of treatment engagement moderators impacting treatment outcome,clients who repeated more session content were more likely to complete treatment(0R=1.84,p=0.037).Conclusion Identification of client-level predictors of treatment engagement,outcome and dropout is essential to optimise treatment,particularly in community settings. | Soo-jeong Youn Margaret-Anne Mackintosh Shannon Wiltsey Stirman Kay lie A Patrick Yesenia Aguilar Silvan Anna D Bartuska Derri L Shtasel Luana Marques | 2019 | General Psychiatry2019，32，6： | 2 |
| 4 | Assessment of sala tolerance in rice cultivars in response to salinity problems in California 显示文摘 | Shannon M C Rhoades J D Draper J H | 1998 | Crop Science1998，38，2： | 2 |
| 5 | Parietal lobe contributions to episodic memory retrieval显示文摘 | Wagner A D Shannon B J Kahn I | 2005 | Trends Cogn Sci2005，9，： | 1 |
| 6 | Influence of age and dose on the end-organ responses to atrial natriuretic peptide in humans显示文摘 | Clark BA Elahi D Shannon RP | 1991 | Am J Hypertens1991，4，： | 1 |
| 7 | 显示文摘 | Shannon R D | 1976 | Acta Crystallogr Sect A1976，32，： | 1 |
| 8 | Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides显示文摘 | Shannon R D | 1976 | Acta Cryst1976，32，： | 1 |
| 9 | In vitro cytokine production by normal human peripheral blood mononuclear cells as a measure of immunocomponent or the state of activation显示文摘 | Friberg D Bryant J Shannon W | 1999 | Clin Diagn Immunol1999，1，3： | 1 |
| 10 | 显示文摘 | Shannon R D | 1993 | J Appl Phys1993，73，： | 1 |
| 11 | Soil water and tempera- ture regimes in drip and sprinkler irrigation, and implications to soy- bean emergence显示文摘 | Wang D Shannon M C Grieve C M et at | 2000 | Agricultural Water Management2000，43，： | 1 |
| 12 | Revised ejective ionic radii and systematic studies of interatomic distance in halides and chalcogenides 显示文摘 | SHANNON R D | 1976 | Actacrystallogr A1976，32，： | 1 |
| 13 | Revised ejective ionic radii and systematic studies of interatomic distance in halides and chalcogenides显示文摘 | SHANNON R D | 1976 | Acta Crystallogr A1976，32，1： | 1 |
| 14 | Biomechanical anal- ysis of anterior poly-methyl-methacrylate reconstruction following total spondylectomy for metastatic disease显示文摘 | Shannon FJ DiResta GR Ottaviano D | 2004 | Spine (Phila Pa 1976)2004，29，19： | 1 |
| 15 | Revised Effective Ionic Radii and Systematic Studies of Interatomic Distances in Ha/ides and Chaleogenides 显示文摘 | Shannon R D | 1976 | Acta Crystallographic Section A : Foundations1976，32，： | 1 |
| 16 | 查看详情显示文摘 | Shannon R D | | 0，，5： | 1 |
| 17 | Indentification of mutator insertional mutants of starch branching enzyme 2a in corn显示文摘 | Yuan Yao Klucinec J D Shannon J C Thompson D B Guilitinan M J | 2001 | plant physiol2001，125，： | 1 |
| 18 | A simple method for evaluation of sprout characters in soybean 显示文摘 | Lee J D Shannon J G Jeong Y S | 2007 | guphytica2007，153，12： | 1 |
| 19 | Inferring Internet Denial of Service Activity 显示文摘 | Moore D Shannon C Brown D J | 2006 | ACM Transactions on Computer Systems2006，24，2： | 1 |
| 20 | Fundamen- tal aspects of stress corrosion cracking显示文摘 | DANAL D SHANNON W BOGGS J E | 1959 | Corro- sion1959，，： | 1 |
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