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| 1 | Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?显示文摘Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue(NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is essential to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. Since antiviral immunity plays an essential role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe NA discontinuation in both groups. | Elia Moreno-Cubero Robert T Sánchez del Arco Julia Pena-Asensio Eduardo Sanz de Villalobos Joaquín Míquel Juan Ramón Larrubia | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 2 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 3 | Supercritical water oxidation process under energetically self-sufficient operation 显示文摘 | Cocero M J Alonso E Sanz M T | 2002 | Journal of Supercritical Fluids2002，24，1： | 2 |
| 4 | Study of photodegradation of the pefticide ethiofencarb in aqueous and non - aqueous media, by gas chromatograghy - mass spectrometry 显示文摘 | J Sanze - Asensio M Plaza - Medina M T Martinez - Soria M Perez -Clavijo | 1999 | Journal of Chromatograghy A1999，84，： | 2 |
| 5 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 6 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 7 | Amyloid beta peptide-induced cholinergic fibres loss in the cerebral cortex of the rat is modified by diet high in lipids and by age显示文摘 | Gonzalo-Ruiz A Sanz J M Arévalo J | 2005 | J Chem Neuroanat2005，29，1： | 1 |
| 8 | Long-term results and survival rate of implants treated with guided bone regeneration: a 5-year case series prospective study显示文摘 | Blanco J Alonso A Sanz M | 2005 | Clin Oral hnplants Res2005，16，3： | 1 |
| 9 | Comparison of potent odorants in a faltered coffee brew and in an instant coffee beverage by aroma extract dilution analysis (AEDA)显示文摘 | SANZ C CZERNY M CID C | 2002 | European Food Research and Technology2002，214，： | 1 |
| 10 | The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation显示文摘 | Sanz L Sanchez P Lallena M J | 1999 | EMBO J1999，18，11： | 1 |
| 11 | Aluminium foams as structured supports fur volatile organic compounds( VOCs )oxidation显示文摘 | Sanz O Echave F J Sanchez M | 2008 | Applied Catalysis: Genera2008，340，1： | 1 |
| 12 | Analysis of volatile components of manchego cheese by dynamic head-space followed by automatic thermal desorption GC-MS 显示文摘 | Villasenor M J L Valero E Sanz J | 2000 | Milchwissenschaft2000，55，7： | 1 |
| 13 | Effects of flavonoids on naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice 显示文摘 | Gil B Sanz M J Terencio M C | 1994 | Life Sci1994，54，： | 1 |
| 14 | Somatic embryogenesis and plant regenerarion from barley cuhivars grown in spain 显示文摘 | Castillo A Egana B Sanz J M | 1995 | Plant Cell Rep1995，17，： | 1 |
| 15 | Defini-tion of relapse risk and role of nonanthracycline drugsfor consolidation in patients with acute promyelocyticleukemia: A joint study of the PETHEMA andG1MEMA cooperative groups 显示文摘 | SANZ M A LO COCO F MARTIN G | 2000 | Blood2000，96，： | 1 |
| 16 | Modem approaches to treating acute promyelocytic leukemia 显示文摘 | SANZ M A LO-COCO F | 2011 | Journal of Clinical Oncology2011，29，5： | 1 |
| 17 | Effect of breed on the muscle glycogen content and dark cutting incidence in stressed young bulls显示文摘 | SANZ M C VERDE M T SAEZ T | 1996 | Meat Science1996，43，1： | 1 |
| 18 | Genomic organization and subchromosomal in situ localization of the murine granzyme F, a serine protease expressed in CD8^+ T cells显示文摘 | Jenne DE Zimmer M Garcia Sanz JA | 1991 | J Immunol1991，147，3： | 1 |
| 19 | Pituitary abscess: a report of two cases显示文摘 | Danilowicz K Sanz CF Manavela M | 2008 | Pituitary2008，11，1： | 1 |
| 20 | Real time Control Strategies for Predenitrification - Nitrification Activated Sludge Plants Biodegradation Control 显示文摘 | OSTOLAZA X GARCIA- SANZ M | 2001 | Water Science and Tech nology2001，43，1： | 1 |
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