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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Wettability of Nickel Coated Graphite by Aluminum显示文摘 | Ip S W Sridhar R Toguri J M | 1998 | Materials Science and Engineering A1998，244，： | 1 |
| 3 | Updated spirometric reference values for adult Chinese in Hong Kong and implications on clinical utilization显示文摘 | IP M S M KO F W S LAU A C | 2006 | CHEST2006，129，2： | 1 |
| 4 | Aluminum foam stabilization by solid particles显示文摘 | Ip S W Wang Y Toguri J M | 1999 | Canadian Metallurgical Quarterly1999，38，1： | 1 |
| 5 | Complex Character Decomposition Using Deformable Model显示文摘 | Chung F L Ip W W S | 2001 | IEEE Transactions on Systems Man and Cybernetics Part C: Applications and Reviews2001，31，1： | 1 |
| 6 | The effects of a child- birth psychoeducation program on learned resourceful- ness, maternal role competence and perinatal depres- sion: a quasi-experiment显示文摘 | Ngai F W Chan S W Ip W Y | 2009 | Int J Nurs Stud2009，46，10： | 1 |
| 7 | Mammary cancer prevention by conjugated dienoic of linoleic acid显示文摘 | Ip C Chin S F Scimeca J A Pariza M W | 1991 | Cancer Research1991，，51： | 1 |
| 8 | Endobronchial tuberculosis revisited 显示文摘 | Ip M S So S Y Lam W K | 1986 | Chest1986，89，5： | 1 |
| 9 | Mannose-binding lectin and rheumatoid arthritis in southern Chinese显示文摘 | IP W K CHANS Y LAU C S | 2000 | Arthritis Rheum2000，43，8： | 1 |
| 10 | Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats显示文摘 | Tjong Y W Ip S P Lao L | 2011 | Neurogastroenterol Motil2011，23，7： | 1 |
| 11 | pRb-expressing adenovirus Ad5-Rb attennates the p53-induced apoptosis in cervical cancer cell lines显示文摘 | Ip S M Huang T G Yeung W S | 2001 | Eur J Cancer2001，37，18： | 1 |
| 12 | Association of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin gene显示文摘 | Ip W K Chan S Y Lau C S | 1998 | Arthritis Rheum1998，41，： | 1 |
| 13 | Endobronchial tuberculosis revisited显示文摘 | IP M S SO S Y LAM W K | 1986 | Chest1986，89，5： | 1 |
| 14 | Psychosocial corre- lates of fluid compliance among Chinese hemodialysis patients 显示文摘 | Pang S K Ip W Y Chang A M | 2001 | Journal of Advanced Nursing2001，35，5： | 1 |
| 15 | Modeling Supply Chain Performance and Stability显示文摘 | Ip W H Chan S L Lam C Y | 2011 | Industrial Management and Data Sys- tems2011，111，8： | 1 |
| 16 | Multi-product planning and scheduling using genetic algorithm approach显示文摘 | Ip W H Li Y Man K F Tang K S | 2000 | Computers & Industrial Engineering (S0360-8352)2000，38，3： | 1 |
| 17 | Improved Pt/Au and W/Pt/Au Schottky contacts on n-type ZnO using ozone cleaning显示文摘 | IP K GILA B P ONSTINE A H LAMBERS E S HEO Y W BAlK K H NORTON D P PEARTON S J KIM S LAROCHE J R REN F | 2004 | Appl Phys Lett2004，84，25： | 1 |
| 18 | Design of an improved quantum - inspired evolutionary algorithm for a transportation problem in logistics systems 显示文摘 | Wang L Kowk S K Ip W H | 2012 | Journal of Intelligent Manufacturing2012，23，6： | 1 |
| 19 | Recent progress in processing and properties of ZnO显示文摘 | PEARTON S J NORTON D P IP K HEO Y W STEINER T | 2005 | Prog Mater Sci2005，50，3： | 1 |
| 20 | Aluminum foam stabilization by solid particles 显示文摘 | IP S W WANG Y TOGURI J M | 1999 | Canadian Metallurgical Quarterly1999，38，： | 1 |
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