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| 1 | High-level classification of the Fungi and a tool for evolutionary ecological analyses显示文摘High-throughput sequencing studies generate vast amounts of taxonomic data.Evolutionary ecological hypotheses of the recovered taxa and Species Hypotheses are difficult to test due to problems with alignments and the lack of a phylogenetic backbone.We propose an updated phylum-and class-level fungal classification accounting for monophyly and divergence time so that the main taxonomic ranks are more informative.Based on phylogenies and divergence time estimates,we adopt phylum rank to Aphelidiomycota,Basidiobolomycota,Calcarisporiellomycota,Glomeromycota,Entomophthoromycota,Entorrhizomycota,Kickxellomycota,Monoblepharomycota,Mortierellomycota and Olpidiomycota.We accept nine subkingdoms to accommodate these 18 phyla.We consider the kingdom Nucleariae(phyla Nuclearida and Fonticulida)as a sister group to the Fungi.We also introduce a perl script and a newick-formatted classification backbone for assigning Species Hypotheses into a hierarchical taxonomic framework,using this or any other classification system.We provide an example of testing evolutionary ecological hypotheses based on a global soil fungal data set. | Leho Tedersoo Santiago Sanchez-Ramırez Urmas Koljalg Mohammad Bahram Markus Doring Dmitry Schigel Tom May Martin Ryberg Kessy Abarenkov | 2018 | Fungal Diversity2018，，3： | 7 |
| 2 | Ranking higher taxa using divergence times:a case study in Dothideomycetes显示文摘The current classification system for the recognition of taxonomic ranks among fungi,especially at highranking level,is subjective.With the development of molecular approaches and the availability of fossil calibration data,the use of divergence times as a universally standardized criterion for ranking taxa has now become possible.We can therefore date the origin of Ascomycota lineages by using molecular clock methods and establish the divergence times for the orders and families of Dothideomycetes.We chose Dothideomycetes,the largest class of the phylum Ascomycota,which contains 32 orders,to establish ages at which points orders have split;and Pleosporales,the largest order of Dothideomycetes with 55 families,to establish family divergence times.We have assembled a multi-gene data set(LSU,SSU,TEF1 and RPB2)from 391 taxa representing most family groups of Dothideomycetes and utilized fossil calibration points solely from within the ascomycetes and a Bayesian approach to establish divergence times of Dothideomycetes lineages.Two separated datasets were analysed:(i)272 taxa representing 32 orders of Dothideomycetes were included for the order level analysis,and(ii)191 taxa representing 55 families of Pleosporales were included for the family level analysis.Our results indicate that divergence times(crown age)for most orders(20 out of 32,or 63%)are between 100 and 220 Mya,while divergence times for most families(39 out of 55,or 71%)are between 20 and 100 Mya.We believe that divergence times can provide additional evidence to support establishment of higher level taxa,such as families,orders and classes.Taking advantage of this added approach,we can strive towards establishing a standardized taxonomic system both within and outside Fungi.In this study we found that molecular dating coupled with phylogenetic inferences provides no support for the taxonomic status of two currently recognized orders,namely Bezerromycetales and Wiesneriomycetales and these are treated as synonyms of Tubeufiales while Asterotexiales is treated as a synonym of Asterinales.In addition,we provide an updated phylogenetic assessment of Dothideomycetes previously published as the Families of Dothideomycetes in 2013 with a further ten orders and 35 families. | Jian-Kui Liu Kevin D.Hyde Rajesh Jeewon Alan J.L.Phillips Sajeewa S.N.Maharachchikumbura Martin Ryberg Zuo-Yi Liu Qi Zhao | 2017 | Fungal Diversity2017，，3： | 3 |
| 3 | Safety and efficacy of Profermin~to induce remission in ulcerative colitis显示文摘AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC. | Aleksander Krag Hans Israelsen Bjrn von Ryberg Klaus K Andersen Flemming Bendtsen | 2012 | World Journal of Gastroenterology2012，18，15： | 2 |
| 4 | A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: effects on CSF glutamate, aspartate, branchedchain amino acid levels and clinical parameters显示文摘 | RYBERG H ASKMARK H PERSSON LI | 2003 | Acta Neurol Seand2003，108，1： | 1 |
| 5 | Chromosome aberrations in tunnel workers exposed to aerylamide and N- methylolacrylamide 显示文摘 | Kjuus H Hansteen IL Ryberg D | 2005 | Scand J Work Environ Health2005，31，4： | 1 |
| 6 | Enotypes of glutathione Stransferase M1, and P1 and their significance for lung DAN adduct levels and cancer risk显示文摘 | Ryberg D Skaug V Hewer A | 1997 | Carcinogensis1997，18，： | 1 |
| 7 | Epirubicin cardiotoxicity:an analysis of 469 patients with metastatic breast cancer显示文摘 | Ryberg M Nielsen D Skovsgaard T | 1998 | J Clin Onco11998，16，11： | 1 |
| 8 | Acute rupture of the Achilles tendon显示文摘 | Movin T Ryberg A McBride DJ | 2005 | Foot Ankle Clin2005，10，2： | 1 |
| 9 | Acute rupture of the Achilles tendon 显示文摘 | Movin T Ryberg A McBride DJ | 2005 | Foot Ankle Clin2005，10，2： | 1 |
| 10 | Sex diffe- rences in lung C-YP1A1 expression and DNA adduct levels among lung cancer patients 显示文摘 | MOLLERUP S RYBERG D HEWER A | 1999 | Cancer Res1999，59，14： | 1 |
| 11 | Intraspecific ITS variability in the kingdom Fungi as expressed in the international sequence databases and its implications for molecular species identification显示文摘 | Nilsson R H Kristiansson E Ryberg M | 2008 | Evolutionary Bioinformatics Online2008，4，1： | 1 |
| 12 | Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA ad duet levels and cancer risk显示文摘 | Ryberg D Skaug V Hewer A | 1997 | Carcinogenesis1997，18，7： | 1 |
| 13 | p53 mutations in lung tumors: relationship to putative susceptibility markers for cancer 显示文摘 | Ryberg D Kure E Lystad S | 1994 | Cancer Res1994，54，6： | 1 |
| 14 | Taxonomic reliability of DNA sequences in public sequence databases:a fungal perspective显示文摘 | Nilsson RH Ryberg M Kristiansson E | 2006 | Plos One2006，1，1： | 1 |
| 15 | Sex differences in lung CYPIAI expression and DNA adduct levels among lung cancer patients显示文摘 | Steen Mollerup David Ryberg Allan Hewer | 1999 | Cancer Research1999，59，15： | 1 |
| 16 | Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients 显示文摘 | Mollemp S Ryberg D Hewer A | 1999 | Cancer Res1999，59，14： | 1 |
| 17 | P53 mutations in lung tumours:relationship to gender and DNA adduct levels显示文摘 | Kure EH Ryberg D Hewer A | 1996 | Carcinogenesis1996，17，10： | 1 |
| 18 | Human CYP1A1 (cytochrome P450) gene:lack of association between the MSPI restriction fragment length polymorphisms and incidence of lung cancer in a Norwegian population显示文摘 | Tefre T Ryberg D H augen A | 1991 | Pharmacogenetics1991，1，1： | 1 |
| 19 | GSTM1 and NAT2 polymorphisms in operable and non-operable lung cancer patients显示文摘 | Hou S M Ryberg D Falt S | 2000 | Carcinogenesis2000，21，1： | 1 |
| 20 | Different susceptibility to smoking-induced DNA damage male and female lung cancer patients显示文摘 | Ryberg D Hewer A Phillips DH | 1994 | Cancer Res1994，54，22： | 1 |
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