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| 1 | The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients. | Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens | 2016 | Bone Research2016，4，2： | 6 |
| 2 | The effects of corporate governance on firms’ credit ratings显示文摘 | Hollis Ashbaugh-Skaife Daniel W. Collins Ryan LaFond | 2006 | Journal of Accounting and Economics2006，，1： | 2 |
| 3 | Dry deposition of gaseous elemental mercury to plants and soils using mercury stable isotopes in a controlled environment显示文摘 | Andrew P. Rutter James J. Schauer Martin M. Shafer Joel E. Creswell Michael R. Olson Michael Robinson Ryan M. Collins Andrew M. Parman Tanya L. Katzman Justin L. Mallek | 2010 | Atmospheric Environment2010，，4： | 1 |
| 4 | Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia 显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，2： | 1 |
| 5 | Entertaining international visitors: the hybrid nature of tourist shows 显示文摘 | Ryan C and Collins A B | 2008 | Tourism Recreation Research2008，，2： | 1 |
| 6 | Impaired fasting glucose tolerance in first-episode,drug-nave patiences with schizophrenia显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，： | 1 |
| 7 | The Effect of SOX Internal Control Deficiencies and Their Remedi ation on Accrual Quality显示文摘 | Hollis Ashbaugh - Skaife Daniel W Collins William R Kinney Jr Ryan LaFond | 2008 | The Accounting Review2008，83，1： | 1 |
| 8 | Response of pinon and juniper respiration to drought and warming显示文摘 | COLLINS A MCDOWELL N RYAN M | 2014 | International Forestry Review2014，16，5： | 1 |
| 9 | Impaired fasting glucose tolerance in first-episode,drug-naive patients with schizophrenia显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，2： | 1 |
| 10 | Impaired fasting glucose toler-ance in first-episode,drug-naive patients with schizophrenia显示文摘 | Ryan MC Collins P Thakore JH | | 0，，02： | 1 |
| 11 | Impaired fasting glucose tolerance in first-episode , drug-naive patients with schizophrenia显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，2： | 1 |
| 12 | Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia 显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，： | 1 |
| 13 | Needle-tract implantation from hepatocellular cancer:Is needle biopsy of the liver always necessary?显示文摘 | Ryan Takamori Linda L. Wong Collin Dang Livingston Wong | 2000 | Liver Transplantation2000，，1： | 1 |
| 14 | Adalimumab treatment for severe recalcitrant chronic plaque psoriasis 显示文摘 | Ryan C Kirby B Collins P | 2009 | Clin Exp Dermatol2009，34，7： | 1 |
| 15 | Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia 显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，2： | 1 |
| 16 | Impaired fasting glucose tolerance in first-episode, dug-naive patients with schizophrenia显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，2： | 1 |
| 17 | Impaired fasting glucose tolerance in fist-episode, drug-naive patients with schizophremia显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，： | 1 |
| 18 | Insights into the Origin of Water Soluble Organic Carbon in Atmospheric Fine Particulate Matter显示文摘 | David C. Snyder Andrew P. Rutter Ryan Collins Chris Worley James J. Schauer | 2009 | Aerosol Science and Technology2009，，11： | 1 |
| 19 | The Effect of SOX Internal Control Deficiencies and Their Remediation on Accrual Quality显示文摘 | Ashbaugh-Skaife Collins Kinney Ryan La Fond | 2008 | The Accounting Review2008，6，83： | 1 |
| 20 | Business networks and the uptake of sustainability practices: the case of New Zealand显示文摘 | Eva Collins Stewart Lawrence Kathryn Pavlovich Chris Ryan | 2006 | Journal of Cleaner Production2006，，8： | 1 |
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