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| 1 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 2 | An Integrated Analysis of Risk Factors of Cognitive Impairment in Patients with Severe Carotid Artery Stenosis显示文摘Objective To investigate cognitive dysfunction in patients with carotid artery stenosis(CAS) and potential risk factors related to cognitive-especially memory-dysfunction. Methods Forty-seven patients with carotid artery stenosis were recruited into our study cohort. The Mini-Mental State Examination(MMSE) and the Montreal Cognitive Assessment(MoCA) were adopted to assess cognitive function, the Wechsler Memory Scale(WMS) to assess memory function, high-resolution MRI and enhanced ultrasound to evaluate carotid plaques, and computed tomography perfusion(CTP) imaging to evaluate intracranial blood perfusion. Single-factor analysis and multiple-factor regression analysis were used to analyze potential risk factors of cognitive impairment. Results Mini-Mental State Examination test results showed that 22 patients had cognitive impairment, and MoCA test results showed that 10 patients had cognitive impairment. Analysis of various risk factors indicated that the average memory quotient of female patients was higher than that of males(P = 0.024). The cognitive and memory performance of those with an educational background above high school were significantly better than those of participants with high school or lower(P = 0.045). Patients with abnormal intracranial perfusion performed worse on the MMSE test(P = 0.024), and their WMS scores were significantly lower(P = 0.007). The MMSE scores and the memory quotients were significantly lower in patients with a history of cerebral infarction(MMSE, P = 0.047, memory quotient score, P = 0.018). Conclusion A history of cerebral infarction and abnormal cerebral perfusion are associated with decline in overall cognitive function and memory in patients with carotid stenosis. Being female and having an educational background above high school may be protective factors in the development of cognitive dysfunction. | LUO Ru Tao WANG Pei Jiong DENG Xiao Feng ZHOU Shu Jie ZHAO Meng QIAN Jing ZHANG Dong WANG Rong ZHANG Yan | 2018 | Biomedical and Environmental Sciences2018，31，11： | 17 |
| 3 | The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment显示文摘Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. | LI Ming Hui ZHANG Lu QU Xiao Jing LU Yao SHEN Ge LI Zhen Zhen WU Shu Ling LIU Ru Yu CHANG Min HU Lei Ping HUA Wen Hao SONG Shu Jing WAN Gang XIE Yao | 2017 | Biomedical and Environmental Sciences2017，30，3： | 14 |
| 4 | Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM] and GSTT1显示文摘AIM In order to study the association betweenthe null genotypes of GSTM1 and GSTT1 and thegenetic susceptibility to hepatocellularcarcinoma(HCC).METHODS The genotypes of GSTM1 and GSTT1of 63 cases of HCC and 88 controls were detectedwith the multiple PCR technique.RESULTS The frequency of GSTM1 nullgenotype was 57.1% among the cases,and42.0% among the controls,the difference beingstatistically significant(χ~2=3.35,P=0.067),but χ~2 value approaching the significance level.The odds ratio was 1.84(95% Cl= 0.91-3.37).The frequency of GSTT1 non-null genotype was87.3% among the cases and 52.5% among thecontrols,the difference being statisticallysignificant(χ~2=11.42,P=0.0007274).The oddsratio was 4.13(95% Cl=1.64-10.70).According to the cross analysis,the GSTT1 non-null genotype was more closely associated withHCC than GSTM1 null genotype,and these twofactors play an approximate additive interactionin the occurrence of HCC.CONCLUSION The persons with GSTM1 nullgenotype and GSTT1 non-null genotype have theincreased risk to HCC. | Jian Chao Bian Fu Min Shen Li Shen Tian Ru Wang Xiao Hong Wang Gong Chao Chen Jin Bing Wang Department of Epidemiology,Shanghai Medical University,Shanghai 200032,China Haimen Municipal Anti-Epidemic and Health Station,Haimen 226201,Jiangsu Province,China Qidong Institute for Liver Cancer,Qidong 226200,Jiangsu Province,China | 2000 | World Journal of Gastroenterology2000，6，2： | 12 |
| 5 | A Systemic Review of Autologous Fat Grafting Survival Rate and Related Severe Complications显示文摘 | Nan-Ze Yu Jiu-Zuo Huang Hao Zhang Yang Wang Xiao-Jun Wang Ru Zhao Ming Bai Xiao Long | 2015 | Chinese Medical Journal2015，，9： | 12 |
| 6 | Hydrogen sulfide facilitates carotid sinus baroreceptor activity in anesthetized male rats显示文摘背景氢硫化物(H2S ) 能由 KATP 隧道的直接激活和膜潜力的 hyperpolarization 放松脉管的光滑的肌肉,这被报导了。最近,我们的学习证明了 H2S 便于颈动脉 baroreflex。这研究被进行在颈动脉 baroreceptor 上调查 H2S 的效果活动( CBA ) .Methods 颈动脉 baroreceptor ( FCCB )的功能的曲线被构造,颈动脉 baroreceptor 的功能的参数被记录湾穴神经测量在有酒的孤立的颈动脉 sinus.Results H2S 的 anesthetized 男性老鼠的传入的分泌物(发源从 NarHS ) 25 , 50 和 100 mol/L 便于 CBA ,它转移了 FCCB 到左, upward.There 是山峰斜坡( PS )的显著增加一有 glibenclamide (20 mol/L ) 的预告的处理, KATP 隧道 blocker, CBA 上的 H2S 的上述效果被废除。有海湾 K8644 的预告的处理(钙隧道的收缩筋, 500 nmol/L ) 在 CBA 上消除了 H2S 的角色。 cystathionine Y-lyase ( CSE )的一个禁止者, DL-propargylglycine ( PPG , 200 mol/L )在到我们的结果建议的右和 downward.Conclusions 的雄的老鼠和转移 FCCB 的禁止的 CBA 那外长的 H2S 通过打开 KATP 隧道并且进一步在脉管的光滑的肌肉关上钙隧道在孤立的 CBA 上施加一个 facilitatory 角色。内长的 H2S 可以在 vivo 激活 CBA。 | XIAO Lin WU Yu-ming WANG Ru LIU Yi-xian WANG Fu-wei HE Rui-rong | 2007 | Chinese Medical Journal2007，，15： | 11 |
| 7 | Challenges of 22 nm and beyond CMOS technology显示文摘It is predicted that CMOS technology will probably enter into 22 nm node around 2012. Scaling of CMOS logic technology from 32 to 22 nm node meets more critical issues and needs some significant changes of the technology, as well as integration of the advanced processes. This paper will review the key processing technologies which can be potentially integrated into 22 nm and beyond technology nodes, including double patterning technology with high NA water immersion lithography and EUV lithography, new device architectures, high K/metal gate (HK/MG) stack and integration technology, mobility enhancement technologies, source/drain engineering and advanced copper interconnect technology with ultra-low-k process. | HUANG Ru WU HanMing KANG JinFeng XIAO DeYuan SHI XueLong AN Xia TIAN Yu WANG RunSheng ZHANG LiangLiang ZHANG Xing WANG YangYuan | 2009 | Science in China(Series F)2009，52，9： | 8 |
| 8 | Elevated Resting Heart Rate is Associated with Dyslipidemia in Middle-aged and Elderly Chinese显示文摘Objective To study the relationship between resting heart rate and blood lipid level.Methods A total of 9 415 subjects aged≥40 years were included in the present study.Their resting heart rate was monitored and their serum levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were measured to define dyslipidemia according to the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults.Results The subjects were divided into group A with their resting heart rate<70 beats/min,group B with their resting heart rate=70-79 beats/min,group C with their resting heart rate=80-89 beats/min,and group D with their resting heart rate≥90 beats/min.High TG,TC,and LDL-C were presented across the resting heart rate(Ptrend<0.01).Multiple logistic regression analysis revealed that the risk of high TG and TC was higher in subjects with their resting heart rate≥90 beats/min than in those with their resting heart rate<70 beats/min(OR=1.42;95%CI:1.16-1.74 and OR=1.33;95%CI:1.09-1.64,respectively).Conclusion Elevated resting heart rate is associated with high TG and TC in middle-aged and elderly Chinese subjects. | SUN Ji Chao HUANG Xiao Lin DENG Xin Ru LV Xiao Fei LU Jie Li CHEN Yu Hong BI Yu Fang WANG Wei Qing XU Min NING Guang | 2014 | Biomedical and Environmental Sciences2014，27，8： | 5 |
| 9 | Regular Space-like Hypersurfaces in S1^m+1 with Parallel Para-Blaschke Tensors显示文摘In this paper, we give a complete conformal classification of the regular space-like hypersurfaces in the de Sitter Space S_1^(m+1) with parallel para-Blaschke tensors. | Xing Xiao LI Hong Ru SONG | 2017 | Acta Mathematica Sinica,English Series2017，33，10： | 5 |
| 10 | Identification of the metabolites of biologically active xanthones isolated from Halenia elliptica D.Don by high performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry显示文摘新陈代谢学习在 1-hydroxy-2,3,5-trimethoxyxanthone (HM-1 ) 和 1-hydroxy-2,3,4,7-tetramethoxyxanthone (HM-2 ) 上被执行了,它是从西藏的植物孤立的二生物学上活跃的成分, Halenia elliptica D. 唐,在在 vitro 的老鼠肝微体。联合到离子陷井 time-of-flight 团 spectrometry ( LCMSn-ESI-IT-TOF )的高效液体层析的一个方法被使用在线上分析 HM-1 和 HM-2 的代谢物,并且五代谢物被识别包含 1,5-dihydroxy-2,3-dimethoxyxanthone ( HM-5 ), 1,7-dihydroxy-2,3,4-trimethoxyxanthone ( HM-9 ), 1,4 , 7-trihydroxy-2,3-dimethoxyxanthone ( HM-10 ), 1,4-dihydroxy-2,3,7-trimethoxyxanthone ( HM-11 )和 1,2-dihydroxy-3,4,7-trimethoxyxanthone ( HM-12 )。在这些代谢物之中, HM-9, HM-11,和 HM-12 互相是异构体。结果显示了那 HM-1, HM-2 发生了阶段我在在 vitro 的老鼠微体的 demethylation 的新陈代谢的反应。 | Ru Feng Jian Gong Shi Xiao Wei Liu Chun Tao Che John H.K. Yeung Yan Wang | 2011 | Chinese Chemical Letters2011，22，7： | 4 |
| 11 | Association between Hypertension with Hyperhomocysteinemia and Cognitive Impairment in the Kailuan Community of China:A Cross-sectional Study显示文摘Cognitive impairment,especially dementia,is common in elderly individuals and seriously affects life quality.Dementia is the most severe expression of cognitive impairment characterized by a progressive functional decline in one or more cognitive domains.The prevalence of dementia has increased dramatically,and the number of patients with dementia will reach 130 million in 2050.The worldwide prevalence of dementia among elderly individuals is approximately 5.0%.In China,more than 220 million people aged over 60 years in 2016. | CHEN Xue Yu YANG Yao TANG Zhao Yang LYU Jian SHI Feng Xue CHEN Yan Ru WANG Xiao Hui TAN Tan XING Wei Jia HOU Hai Feng JI Long LI Xiao Dong LI Dong | 2021 | Biomedical and Environmental Sciences2021，34，7： | 3 |
| 12 | Catalytic hydrolysis of phosphate diester (BNPP) and plasmid DNA by mononuclear macrocyclic polyamine metal complexes显示文摘磷酸盐 diest 的催化水解作用的活动嗯(BNPP )[ 二度(p-nitrophenyl ) 磷酸盐 diest 嗯] 并且由单音的原子宏的原生质标志 DNA (pUC18 ) 周期的 polyamine 金属建筑群在这篇论文被调查了。结果证明在 BNPP 的水解作用的最高的活动与 1e – 被获得; Zn (II ) 建筑群(脂性的组镇静) 是催化剂。水解作用率改进直到 3.64 × 10 4 褶层。这些金属建筑群能有效地以生理的条件支持原生质标志 DNA (pUC18 ) 的劈开。 | Qing Xiang Xiang Li Qun Zhang Xiao Qi Yu Ru Gang Xie | 2009 | Chinese Chemical Letters2009，20，5： | 3 |
| 13 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 14 | Monitoring and Assessing Method for Blasting Vibration on Open-pit Slope in Hainan Iron Mine显示文摘A type of velocity sensor CD 1, an auto recording instrument on blasting vibration YBJ 1 and a random signal and vibration analysis system (CRAS) were used to monitor the particle vibration induced by blasting at open pit slope in Hainan Iron Mine. The attenuating rules of blasting ground vibration on slope were developed. By means of the analysis and calculation of the blasting vibration data at open pit slope and the vertical particle vibration velocity assessment method based on the concept of vibration strength, the empirical attenuating equations which can be used for predicting and estimating the damage of slope were derived. | SONG Guang ming 1,SHI Xiu zhi 1,ZHOU Zhi guo 1,CHEN Shou ru 1,XIAO Qing hua 2 (1 College of Resources, Environment and Civil Engineering, Central South University of Technology, Changsha 410083, China 2 Production and Technology Departmen | 2000 | Journal of Central South University2000，12，2： | 3 |
| 15 | Regioselective enzymatic acylation of troxerutin in nonaqueous medium显示文摘A series of monosubstituted troxerutin esters have been synthesized by enzyme-catalyzed regioselective acylation of troxerutin in nonaqueous medium.Using divinyl dicarboxylates(CH_2=CH-OOC-(CH_2)_n-COO-CH=CH_2,n = 2,3,4,7,8,11) featuring different chain length as acyl donors and alkaline protease from Bacillus subtilis as catalyst,troxerutin was regioselective acylated at B' ethoxyl group.The results indicated that the regioselectivity of the enzyme-catalyzed acylation was not affected by the chain lengt... | Xiao, Yong Mei Mao, Pu Zhao, Zhen Yang, Liang Ru Lin, Xian Fu | 2010 | Chinese Chemical Letters2010，21，1： | 3 |
| 16 | Three-year Follow-up on the Safety and Effectiveness of Rituximab Plus Chemotherapy as First-Line Treatment of Diffuse Large B-Cell Lymphoma and Follicular Lymphoma in Real-World Clinical Settings in China: A Prospective, Multicenter, Noninterventional Study显示文摘 | Jian-Qiu WU Yong-Ping Song Li-Ping Su Ming-Zhi Zhang Wei Li Yu Hu Xiao-Hong Zhang Yu-Huan Gao Zuo-Xing Niu Ru Feng Wei Wang Jie-Wen Peng Xiao-Lin Li Xue-Nong Ouyang Chang-Ping Wu Wei-Jing Zhang Yun Zeng Zhen Xiao Ying-Min Liang Yong-Zhi Zhuang Ji-Shi Wang Zi-Min Sun Hai Bai Tong-Jian Cui Ji-Feng Feng | 2018 | Chinese Medical Journal2018，，15： | 3 |
| 17 | The Synthesis of Hexamethyl Ether of Salvianolic Acid A Benzyl Ester显示文摘TheSynthesisofHexamethylEtherofSalvianolicAcidABenzylEsterYanZHUANG;ZongRuGUO;GuangZhongYANG;XiaoTianLIANG(InstituteofMateria... | Yan ZHUANG Zong Ru GUO Guang Zhong YANG Xiao Tian LIANG(Institute of Materia Medica.Chinese Academy of Medical Sciences Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050) | 1996 | Chinese Chemical Letters1996，7，10： | 2 |
| 18 | First total synthesis of a naturally occurring nucleoside disulfide:9-(5'-Deoxy-5'-thio-β-D-xylofuranosyl)adenine disulfide显示文摘A naturally occurring nucleoside disulfide,9-(5'-deoxy-5'-thio-β-D-xylofuranosyl)adenine disulfide,was first synthesized from D-xylose over 7 steps in 20%overall yield.The key step involved Vorbriiggen glycosylation of silylated N^6-benzoyladenine with xylose diacetate moiety. | Hai Xin Ding Ling Cui Da Ru Chun Yang Ban Peng Cao Qi Sun Qiang Xiao | 2012 | Chinese Chemical Letters2012，23，9： | 2 |
| 19 | Development of a low-background neutron detector array显示文摘A low-background neutron detector array was developed to measure the cross section of the ^(13)C(a,n)^(16)O reaction,which is the neutron source for the s-process in AGB stars,in the Gamow window(E_(c.m.)=190±40 keV)at the China Jinping Underground Laboratory(CJPL).The detector array consists of 24^(3)He proportional counters embedded in a polyethylene cube.Owing to the deep underground location and a borated polyethylene shield around the detector array,a low background of 4.5(2)/h was achieved.The ^(51)V(p,n)^(51)Cr reaction was used to determine the neutron detection efficiency of the array for neutrons with energies E_(n)<1 MeV.Geant4 simulations are shown to effectively reproduce the experimental results.They were used to extrapolate the detection efficiency to higher energies for neutrons emitted in the ^(13)C(α,n)^(16)O reaction.The theoretical angular distributions of the ^(13)C(α,n)^(16)O reaction were shown to be important in the estimation of the uncertainties of the detection efficiency. | Yu-Tian Li Wei-Ping Lin Bing-Shui Gao Han Chen Hao Huang Yu Huang Tao-Yu Jiao Kuo-Ang Li Xiao-Dong Tang Xin-Yu Wang Xiao Fang Han-Xiong Huang Jie Ren Long-Hui Ru Xi-Chao Ruan Ning-Tao Zhang Zhi-Chao Zhang | 2022 | Nuclear Science and Techniques2022，33，4： | 2 |
| 20 | Macrophage Migration Inhibitory Factor Is an Important Mediator in the Pathogenesis of Gastric Inflammation in Rats显示文摘 | Xiao Ru Huang Connie Wun Chun Hui Yong-Xiong Chen Benjamin Chun Yu Wong Peter C.W. Fung Christine Metz Chi Hin Cho Wai Mo Hui Richard Bucala Shiu-Kum Lam Hui Y. Lan | 2001 | Gastroenterology2001，，3： | 2 |
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