|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages显示文摘AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of cancer.METHODS:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University Hospital.Patient demographic information,including age and gender,tumor sites,and histological type of CRC,was recorded.To measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal tissues.Reverse transcription and reverse transcription polymerase chain reaction were performed.Colorectal tissue microarrays were constructed to investigate the protein expression of TNF-a by immunohistochemistry.RESULTS:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal tissue.High TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were negative.We showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of tumor.CONCLUSION:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC. | Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 2 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 3 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 4 | Bimodal targeting of microsomal CYP2E1 tomitochondria through activation of an N-terminalchimeric signal by cAMP-mediated phosphorylation显示文摘 | ROBIN M A ANANDATHEERTHAVARADA H K BISWAS G | 2002 | J Biol Chem2002，277，40： | 1 |
| 5 | Maximum likelihood from incomplete data via the EM algorithm显示文摘 | Dempster A P Laird N M Robin D B | 1977 | Journal of the Royal Statistical Society1977，39，1： | 1 |
| 6 | The epidemology of schizophrenia replacing dog- ma with knowledge 显示文摘 | Simona A Robin M | 2010 | Dialogues Clin Neurosci2010，12，： | 1 |
| 7 | Turning, compacting and the addition of water as factors affecting gaseous emissions in farm manure composting显示文摘 | E1 Kader N A Robin P Paillat J M | 2007 | Bioresource Technology2007，98，14： | 1 |
| 8 | Biochar Incorporation into Pasture Soil Suppresses in situ Nitrous Oxide Emissions from Ruminant Urine Patches显示文摘 | Taghizadeh-Toosi Arezoo Clough Tim J Condron Leo M Sherlock Robert R Anderson Craig R Craigie Robin A | 2011 | EN2011，，2： | 1 |
| 9 | Coordination polymer networks with O-and N-donors:What they are,why and how they are made显示文摘 | Robin A Y Fromm K M | 2006 | Coord Chem Rev2006，250，： | 1 |
| 10 | Waterbird assemblages and associated habitat characteristics of farm ponds in the Western Cape, South Africa显示文摘 | Froneman A Michael J M Robin M L | 2001 | Biediversity and Conservation2001，10，2： | 1 |
| 11 | Emergency nursing:Historical,current,and future roles显示文摘 | JOHN A SCHRIVER M D ROBIN TALMADGE R N | 2003 | Journal of Emergency Nursing2003，29，5： | 1 |
| 12 | Elevatedmitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats:tissue-specific variations and roles in oxidative stress显示文摘 | RAZA H PRABU SK ROBIN M A | 2004 | Diabetes2004，53，1： | 1 |
| 13 | Spatial variability of strontium distribution coefficients and their correlation with hydraulic conductivity in the Canadian Forces Air Base Borden aquifer 显示文摘 | ROBIN M J L SUDICKY E A GILLHAM R W | 1991 | Water Resour Res1991，27，10： | 1 |
| 14 | Production of alumi- num foams with Ni coated TiHe powder显示文摘 | Paula M Proa-Flores Robin A L Drew | 2008 | Adv Eng Ma- ter2008，，9： | 1 |
| 15 | Gontrolled Nanofabrication of Highly Oriented Pyrolytic Graphite with the Scanning Tunneling Microscope 显示文摘 | ROBIN L M HENDRIGKS S A BARD A J | 1992 | J Phys Chem1992，96，10： | 1 |
| 16 | Turning,compacting and the addition of water as factors affecting gaseous emissions in farm manure composting显示文摘 | EL KADER N A ROBIN P PAILLAT J M | 2007 | Bioresource Technology2007，98，14： | 1 |
| 17 | Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘 | Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A | 2012 | Ann Rev Earth Planet Sci2012，40，： | 1 |
| 18 | Biochem Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy显示文摘 | ELKAHWAJI J ROBIN M BERSON A | 1999 | Biochem Pharmacol1999，57，8： | 1 |
| 19 | Ganglioside prevent excitoxicity through activation of TrkB receptor显示文摘 | Bachis A Robin SJ Del Fiacco M | 2002 | Neurotox Res2002，4，3： | 1 |
| 20 | Provably good performance-driven global routing显示文摘 | A B Kahng G Robins M Sarrafzadeh C K Wong | 1992 | IEEE Trans1992，11，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员