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| 1 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 2 | Molecular mechanisms regulating expression and function of transcription regulator “inhibitor of differentiation 3”显示文摘区别 3 的抄写因素对手禁止者(Id3 ) 在许多被含有多样发展,生理并且 pathophysiological 过程。它的表示和功能受到复杂规定的许多层次。这评论总结这些机制的当前的理解并且描述他们怎么可能与被归因于 Id3 蛋白质的多样的功能有关。详细说明了这些理解机制应该向各种各样的疾病的治疗学的途径的发展提供卓见,包括癌症和动脉粥样化形成。 | Robert Wai-sui LIM Jin-mei WU | 2005 | Acta Pharmacologica Sinica2005，26，12： | 11 |
| 3 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 4 | The alternative of CubeSat-based advanced infrared and microwave sounders for high impact weather forecasting显示文摘近年来,小卫星技术的发展给传统气象卫星提供了经济有效的替补方案。本文针对可能出现的传统气象卫星的缺失情形,借助快速的区域观测系统模拟试验,探索了利用小卫星填补空缺的可能性。研究表明,单个小卫星,无论是近红外高光谱还是微波探测仪,都能够对局地强风暴天气的预报有所改进。然而,为了填补传统卫星缺失带来的影响,需要发射三颗甚至更多的小卫星来增加观测的覆盖面,以弥补小卫星精度略低、通道略少的缺陷。 | LI Zhenglong LI Jun SCHMIT Timothy J. WANG Pei LIM Agnes LI Jinlong NAGLE Fredrick W. BAI Wenguang OTKIN Jason A. ATLAS Robert HOFFMAN Ross N. BOUKABARA Sid-Ahmed ZHU Tong BLACKWELL William J. PAGANO Thomas S. | 2019 | Atmospheric and Oceanic Science Letters2019，12，2： | 3 |
| 5 | Value-added Impact of Geostationary Hyperspectral Infrared Sounders on Local Severe Storm Forecasts——via a Quick Regional OSSE显示文摘Accurate atmospheric temperature and moisture information with high temporal/spatial resolutions are two of the key parameters needed in regional numerical weather prediction(NWP) models to reliably predict high-impact weather events such as local severe storms(LSSs). High spectral resolution or hyperspectral infrared(HIR) sounders from geostationary orbit(GEO) provide an unprecedented source of near time-continuous, three-dimensional information on the dynamic and thermodynamic atmospheric fields—an important benefit for nowcasting and NWP-based forecasting. In order to demonstrate the value of GEO HIR sounder radiances on LSS forecasts, a quick regional OSSE(Observing System Simulation Experiment)framework has been developed, including high-resolution nature run generation, synthetic observation simulation and validation, and impact study on LSS forecasts. Results show that, on top of the existing LEO(low earth orbit) sounders, a GEO HIR sounder may provide value-added impact [a reduction of 3.56% in normalized root-mean-square difference(RMSD)] on LSS forecasts due to large spatial coverage and high temporal resolution, even though the data are assimilated every 6 h with a thinning of 60 km. Additionally, more frequent assimilations and smaller thinning distances allow more observations to be assimilated, and may further increase the positive impact from a GEO HIR sounder. On the other hand, with denser and more frequent observations assimilated, it becomes more difficult to handle the spatial error correlation in observations and gravity waves due to the limitations of current assimilation and forecast systems(such as a static background error covariance). The peak reduction of 4.6% in normalized RMSD is found when observations are assimilated every 3 h with a thinning distance of 30 km. | Zhenglong LI Jun LI Pei WANG Agnes LIM Jinlong LI Timothy J.SCHMIT Robert ATLAS Sid-Ahmed BOUKABARA Ross N.HOFFMAN | 2018 | Advances in Atmospheric Sciences2018，35，10： | 3 |
| 6 | The relationship of in vivo 31 P MR spectroscopy to histology in chronic hepatitis C显示文摘 | Adrian K.P. Lim Nayna Patel Gavin Hamilton Joseph V. Hajnal Robert D. Goldin Simon D. Taylor-Robinson | 2003 | Hepatology2003，，4： | 2 |
| 7 | 莱菔硫烷对头颈癌细胞系PCI-13中信号转导和转录激活因子1和3的影响显示文摘目的:研究莱菔硫烷(SFN)对头颈癌细胞系PCI-13中信号转导和转录激活因子1和3(STAT1,STAT3)的影响,探讨STAT/JAK途径在SFN抗肿瘤中的作用。方法:体外培养PCI-13细胞,经血清饥饿后,分别用0、10、20、40μmol/L的SFN处理3、6、12、24 h。为检测IL-6诱导的STAT3激活情况,用20、40μmol/L的SFN处理24 h,再用50 ng/ml的IL-6处理15min。设阴性和阳性对照组。分别获取细胞后,采用流式细胞术检测磷酸化-STAT(p-STAT)1和3的表达。结果:SFN对pSTAT1表达无影响,但可以显著抑制p-STAT3的表达,还可以抑制IL-6诱导的p-STAT3的升高,这种抑制存在浓度和时间依赖性。结论:SFN能够抑制PCI-13细胞中的STAT3的磷酸化水平,减少其构成性激活和IL-6诱导的激活,提示SFN诱导PCI-13细胞凋亡可能由STAT/JAK途径介导。 | 贾志宇 赵云转 王维丽 张英怀 Chweeming Lim Robert L Ferris | 2013 | 实用口腔医学杂志2013，29，6： | 2 |
| 8 | 舒尼替尼阻断STAT3通路抑制头颈鳞癌细胞PCI-13增殖显示文摘目的体外研究舒尼替尼对头颈鳞癌细胞系PCI-13增殖和凋亡的影响,并观察STAT1、STAT3在凋亡过程中的变化,探讨STAT3通路在舒尼替尼诱导肿瘤细胞凋亡中的作用。方法体外培养PCI-13细胞,用不同浓度的舒尼替尼处理24、48、72 h后,应用MTT比色实验,倒置显微镜、Wright-Giemsa染色、流式细胞术检测和观察PCI-13的生长抑制率和凋亡情况。细胞经血清饥饿后,分别用0、1、2、4μmol/L的舒尼替尼处理2、8、16和24 h,采用流式细胞术检测p-STAT1和3的表达,并设阴性和阳性对照组。结果舒尼替尼可明显抑制PCI-13细胞的增殖,其最高抑制率可达92%,各浓度用药组不同处理时间之间生长抑制率有显著差异(P<0.05),抑制率呈时间-浓度依赖性。同时舒尼替尼可诱导PCI-13细胞凋亡,凋亡率随处理时间延长和药物浓度增加而上升(P<0.05)。舒尼替尼不影响p-STAT1的表达(P>0.05),但是可以显著抑制p-STAT3的表达,这种抑制存在浓度依赖性(P<0.05)。结论舒尼替尼不但能够抑制PCI-13细胞增殖,诱导其凋亡,而且能够抑制PCI-13细胞中STAT3的磷酸化水平,减少其激活。提示舒尼替尼诱导PCI-13细胞凋亡可能由STAT/JAK途径介导。 | 贾志宇 赵云转 屈鹏飞 张英怀 Lim Chweeming Robert L Ferris | 2014 | 第三军医大学学报2014，36，1： | 2 |
| 9 | Interleukin- 6 in experimental endometriosis显示文摘 | YONGE- TAIK LIM ROBERT S SCHENKEN | 1993 | Ferti Steri1993，59，4： | 1 |
| 10 | The Acute Hemodynamic Effects of MitraClip Therapy显示文摘 | Robert J. Siegel Simon Biner Asim M. Rafique Michael Rinaldi Scott Lim Peter Fail James Hermiller Richard Smalling Patrick L. Whitlow Howard C. Herrmann Elyse Foster Ted Feldman Donald Glower Saibal Kar | 2011 | Journal of the American College of Cardiology2011，，16： | 1 |
| 11 | Online Pattern Classification With Multiple Neural Network Systems:An Experimental Study显示文摘 | Chee Peng Lim Robert F.Harrison | | 0，，： | 1 |
| 12 | A phase I study of oxaliplatin in combination with gemcitabine: correlation of clinical outcome with gene expression显示文摘 | Stephen Shibata Warren Chow Paul Frankel Agnes Juhasz Lucille Leong Dean Lim Kim Margolin Robert Morgan Edward Newman George Somlo Yun Yen Timothy Synold David Gandara Heinz-Josef Lenz James Doroshow | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
| 13 | The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection显示文摘 | Edward J. Gane Young-Suk Lim Stuart C. Gordon Kumar Visvanathan Eric Sicard Richard N. Fedorak Stuart Roberts Benedetta Massetto Zhishen Ye Stefan Pflanz Kimberly L. Garrison Anuj Gaggar G. Mani Subramanian John G. McHutchison Shyamasundaran Kottilil Brad | 2015 | Journal of Hepatology2015，，2： | 1 |
| 14 | Reverse Anterior Tibial Artery Flap for Reconstruction of Foot Donor Site显示文摘 | Jia Sheng Dong Yeong Pin Peng Yi Xin Zhang Beng Hai Lim Robert W. H. Pho | 2003 | Plastic and Reconstructive Surgery2003，，6： | 1 |
| 15 | Directed Evolution of High-Affinity Antibody Mimics Using mRNA Display显示文摘 | Lihui Xu Patti Aha Ke Gu Robert G. Kuimelis Markus Kurz Terence Lam Ai Ching Lim Hongxiang Liu Peter A. Lohse Lin Sun Shawn Weng Richard W. Wagner Dasa Lipovsek | 2002 | Chemistry & Biology2002，，8： | 1 |
| 16 | Vertebroplasty comparing injectable calcium phosphate cement compared with polymethylmethacrylate in a unique canine vertebral body large defect model显示文摘 | Thomas M. Turner Robert M. Urban Kern Singh Deborah J. Hall Susan M. Renner Tae-Hong Lim Michael J. Tomlinson Howard S. An | 2008 | The Spine Journal2008，，3： | 1 |
| 17 | Iris color and cataract: The Blue Mountains Eye Study显示文摘 | Robert G Cumming Paul Mitchell Ridia Lim | 2000 | American Journal of Ophthalmology2000，，2： | 1 |
| 18 | Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice显示文摘 | Hyunjung Lim Bibhash C Paria Sanjoy K Das Joseph E Dinchuk Robert Langenbach James M Trzaskos Sudhansu K Dey | 1997 | Cell1997，，2： | 1 |
| 19 | High rates of school readiness difficulties at 5 years of age in very preterm infants compared with term controls显示文摘 | Roberts G Lim J Doyle LW Anderson PJ | | 0，，02： | 1 |
| 20 | Pulmonary Exposure to Particles during Pregnancy Causes Increased Neonatal Asthma Susceptibility显示文摘 | Fedulov Alexey V Leme Adriana Yang Zhiping Dahl Morten Lim Robert Mariani Thomas J Kobzik Lester | 2008 | American Journal of Respiratory Cell and Molecular Biology2008，，1： | 1 |
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