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| 1 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 4 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 5 | Effect of spray characteristics on insecticide efficacy 显示文摘 | Randall G L David B S | 1990 | Pestic Formul Applic Syst1990，10，： | 1 |
| 6 | Bidding games for valuation of aesthetic environmental improvements显示文摘 | RANDALL A IVES B EASTMAN C | 1974 | Journal of Environmental Economics and Management1974，，1： | 1 |
| 7 | Differential diagnosis of gear and bearing faults显示文摘 | Antoni J Randall R B | 2002 | Journal of Vibration and Acoustics2002，124，2： | 1 |
| 8 | A new method for separating discrete components from a signal显示文摘 | RANDALL R B SAWALHI N | 2011 | Journal of Sound &Vibration2011，5，： | 1 |
| 9 | Application of a minimum entropy de- convolution filter to enhance Autoregressive model based geartooth fault detection technique 显示文摘 | Endo H Randall R B | 2007 | Mechanical Systems and Signal Processing2007，21，： | 1 |
| 10 | Colo- rectal cancer screening显示文摘 | RANDALL W B JAMES S B KELLI B D | 2010 | J Natl Compr Cane Netw2010，8，： | 1 |
| 11 | The relationship between spectrual correlation and envelope anyalysid in the diagnosis of bearing faults and other cycloststionsry mschine signals显示文摘 | Randall R B | 2001 | Mechanical Systems and Signal Processing2001，15，5： | 1 |
| 12 | The spectral kurtosis:applica-tion to the vibratory surveillance and diagnostics of ro-tating machines显示文摘 | Antoni J Randall R B | 2006 | Mechanical Systems and SignalProcessing2006，20，： | 1 |
| 13 | The enhancement of fault detection and diagnosis in rolling element bearings using mini- mum entropy deconvolution combined, with spectral kurtosis 显示文摘 | Sawalhi N Randall R B Endo H | 2007 | Mechanical Systems and Signal Processing2007，21，： | 1 |
| 14 | The relationship between spectral correlation and envelope analysis in the diagnostics of bearing faults and other cyclostationary machine signals显示文摘 | Randall R B Antoni J Chobsaard S | 2001 | Mechanical Systems and Signal Processing2001，15，5： | 1 |
| 15 | Investigation of a high Tc piezoelectric system: ( 1-x ) Bi ( Mgl/2 Til/2 ) O3 -xPbTiO3 显示文摘 | Randall C A Eitel R Jones B | 2004 | Journal of Applied Physics2004，95，7： | 1 |
| 16 | Blind Source Separation of In- ternal Combustion Engine Piston Slap from Other Measured Vibration Signals显示文摘 | Liu X Randall R B | 2005 | Mechanical System and Signal Processing2005，19，6： | 1 |
| 17 | Blind separation of internal combustion engine vibration signals by a deflation method显示文摘 | LIU Xiardaua Randall R B Antoni J | 2008 | Mechanical Systems and Signal Processing2008，22，5： | 1 |
| 18 | Bidding games for valuation of aesthetic environmental improvements显示文摘 | Randall A Ives B Eastman C | 1974 | Journal of Environ- mental Economics and Management1974，1，2： | 1 |
| 19 | The enhancementof fault detection and diagnosis in rolling element bear-ings using minimum entropy deconvolution combinedwith spectral kurtosis显示文摘 | Sawalhi N Randall R B Endo H | 2007 | Mechanical Systems andSignal Processing2007，21，： | 1 |
| 20 | Gear transmission error measurement using phase demodulation显示文摘 | Sweeney P J Randall R B | 1996 | Journal of Mechanical Engineering Science1996，210，3： | 1 |
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