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| 1 | Plasma and platelet serotonin levels in patients with liver cirrhosis显示文摘AIM: To analyze the relationship between plasma and platelet serotonin levels and the degree of liver insufficiency. METHODS: The prospective study included 30 patients with liver cirrhosis and 30 healthy controls. The degree of liver failure was assessed according to the Child-Pugh classification. Platelet and platelet poor plasma serotonin levels were determined. RESULTS: The mean plasma serotonin level was higher in liver cirrhosis patients than in healthy subjects (215.0 ± 26.1 vs 63.1 ± 18.1 nmol/L; P < 0.0001). The mean platelet serotonin content was not significantly different in patients with liver cirrhosis compared with healthy individuals (4.8 ± 0.6; 4.2 ± 0.3 nmol/platelet; P > 0.05). Plasma serotonin levels were significantly higher in Child- Pugh grade A/B than in grade C patients (246.8 ± 35.0 vs 132.3 ± 30.7 nmol/L; P < 0.05). However, platelet serotonin content was not significantly different between Child-Pugh grade C and grade A/B (4.6 ± 0.7 vs 5.2 ± 0.8 nmol/platelet; P > 0.05). CONCLUSION: Plasma serotonin levels are significantly higher in patients with cirrhosis than in the controls and represent the degree of liver insufficiency. In addition, platelet poor plasma serotonin estimation is a better marker for liver insufficiency than platelet serotonin content. | ■or■e M ulafi Duko S Mirkovi Miodrag D Vukevi Jelena S Rudi | 2007 | World Journal of Gastroenterology2007，13，43： | 5 |
| 2 | Performance of the Montreal classification for inflammatory bowel diseases显示文摘AIM:To validate the Montreal classification system for Crohn's disease(CD) and ulcerative colitis(UC) within the Netherlands.METHODS:A selection of 20 de-identified medical records with an appropriate representation of the inflammatory bowel disease(IBD) sub phenotypes were scored by 30 observers with different professions(gastroenterologist specialist in IBD,gastroenterologist in training and IBD-nurses) and experience level with IBD patient care.Patients were classified according to the Montreal classification.In addition,participants were asked to score extra-intestinal manifestations(EIM) and disease severity in CD based on their clinical judgment.The inter-observer agreement was calculated by percentages of correct answers(answers identical to the 'expert evaluation') and Fleiss-kappa(k).Kappa cutoffs:< 0.4-poor; 0.41-0.6-moderate; 0.61-0.8-good; > 0.8 excellent.RESULTS:The inter-observer agreement was excellent for diagnosis(k = 0.96),perianal disease(k = 0.92) and disease location in CD(k = 0.82) and good for age of onset(k = 0.67),upper gastrointestinal disease(k = 0.62),disease behaviour in CD(k = 0.79) and disease extent in UC(k = 0.65).Disease severity in UC was scored poor(k = 0.23).The additional items resulted in a good inter-observer agreement for EIM(k = 0.68) and a moderate agreement for disease severity in CD(k = 0.44).Percentages of correct answers over all Montreal items give a good reflection of the inter-observer agreement(> 80%),except for disease severity(48%-74%).IBD-nurses were significantly worse in scoring upper gastrointestinal disease in CD compared to gastroenterologists(P = 0.008) and gastroenterologists in training(P = 0.040).Observers with less than 10 years of experience were significantly better at scoring UC severity than observers with 10-20 years(P = 0.003) and more than 20 years(P = 0.003) of experience with IBD patient care.Observers with 10-20 years of experience with IBD patient care were significantly better at scoring upper gastrointestinal disease in CD than observers with less than 10 years(P = 0.007) and more than 20 years(P = 0.007) of experience with IBD patient care.CONCLUSION:We found a good to excellent interobserver agreement for all Montreal items except for disease severity in UC(poor). | Lieke M Spekhorst Marijn C Visschedijk Rudi Alberts Eleonora A Festen Egbert-Jan van der Wouden Gerard Dijkstra Rinse K Weersma | 2014 | World Journal of Gastroenterology2014，20，41： | 4 |
| 3 | A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells显示文摘 | Gunthert U Hofmann M Rudy W | | 0，，： | 2 |
| 4 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 5 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 6 | CD44 splice variants confer metastatic behavior in rats:homologous sequences are expressed in humantumor cell lines显示文摘 | RUDY W ZOLLER M | 1991 | Cancer Res1991，51，： | 1 |
| 7 | A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells显示文摘 | Gunthert U Hofmann M Rudy W | 1991 | Cell1991，65，1： | 1 |
| 8 | Comparison of chicken gut colonisation by the pathogens Campylobacter jejuni and Clostridium perfringens by real-time quantitative PCR显示文摘 | Skanseng B Kaldhusdal M Rudi K | 2006 | Molecular and Cellular Probes2006，20，5： | 1 |
| 9 | A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells显示文摘 | Gunthert U Hofmann M Rudy W | 1991 | Cell1991，65，1： | 1 |
| 10 | A survey of modeling and control of hybrid systems显示文摘 | Labinaz G Bayoumi M M Rudie K | 1997 | Annual Reviews in Control1997，21，： | 1 |
| 11 | Detection of viable and dead Listeria monocytogenes on gouda-like cheeses by real-time PCR显示文摘 | RUDI K NATERSTAD K DRMTORP S M | 2005 | Lett Appl Microbiol2005，40，： | 1 |
| 12 | Effect of NaCl-induced osmotic stress on intracellular concentrations of glycine betaine and potassium in Escherichia coli,Enterococcus faecalis,and staphylococci显示文摘 | Kunin C M Rudy J | 1991 | J Lab Clin Med1991，118，： | 1 |
| 13 | Homocysteine concentrations and vascular complications in patients with type2 diabetes显示文摘 | Rudy A Kowalska I Straczkowski M | 2005 | Diabetes Metab2005，31，2： | 1 |
| 14 | A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells 显示文摘 | Gunthert U Hofmann M Rudy W | 1991 | Cell1991，65，： | 1 |
| 15 | Algal esterase activity as a biomeasure of environmental degradation in a freshwater creek显示文摘 | Rudi H Regel John M Ferris George G Ganf Justin D Brookes | 2002 | Aquatic Toxicology2002，，3： | 1 |
| 16 | The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior 显示文摘 | Rudy W Hofmann M Schwartz-Albiez R | 1993 | Cancer Res1993，53，6： | 1 |
| 17 | A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells显示文摘 | Gunthert U Hofmann M Rudy W el al | 1991 | Cell1991，65，1： | 1 |
| 18 | A new variant of glycoprotein CD44 confer metastatic potential to rat carcinoma cells显示文摘 | Gunthert U Hofmann M Rudy W | 1991 | Cell1991，65，1： | 1 |
| 19 | Homocysteine concentra- tions and vascular complications in patients with type 2 diabetes显示文摘 | F Rudy A Kowalska I Strczkowski M | 2005 | Diabetes Metab2005，31，1： | 1 |
| 20 | A new variant of glycoprotein CD44 confers metastasis potential to rat carcinoma cells显示文摘 | Gunt hert U Hofmann M Rudy W | 1991 | Cell1991，65，1： | 1 |
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