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| 1 | International NeuroAIDS: prospects of HIV-1 associated neurological com-plications显示文摘Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain. | J Roberto TRUJILLO Gilberto JARAMILLO-RANGEL Marta ORTEGA-MARTINEZ Augusto C PENALVA de OLIVEIRA Jose E VIDAL Joseph BRYANT Robert C GALLO | 2005 | Cell Research2005，15，11： | 4 |
| 2 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | 慢性细菌性前列腺炎和肠易激综合征:利福昔明联合益生菌VSL#3的治疗效果显示文摘本研究评价了利福昔明联合益生菌VSL#3对慢性前列腺炎转化为微生物性前列腺精囊炎(PV)或前列腺精囊附睾炎(PVE)的作用。106例伴有细菌学治愈的慢性细胞性前列腺炎和肠易激综合征的男性不育患者随机予以利福昔明(200mg,20:/日,每月服用7日,持续12个月)和益生菌VSL#3(450×10^9CFU/日)治疗及无处理。95名患者(89.6%)完成治疗计划,纳入本研究。将患者分为四组:A组前6个月予治疗,后6月无治疗(n=26);B组予12个月治疗(n=22);C组前6个月不予治疗后6个月予治疗(n=23);D组在12个月内均无治疗(n=24)。A组和B组患者慢性前列腺炎发生率最高(分别为88.5%和86.4%)。相反,D组患者前列腺炎发生率最低(33.4%)。前列腺炎进展为PV的发生率在B组(15.5%)和C组(13.6%)低于D组(45.8%)。B组和C组最终无患者进展为PVE,而D组有20.8%诊断为PVE。长期服用利福昔明联合益生菌VSL#3能有效降低伴有治愈的CBP伴IBS的男性不育患者的前列腺炎进展为更复杂形式的男性附属性腺感染。 | Enzo Vicari Sandro La Vignera Roberto Castiglione Rosita A Condorelli Lucia O Vicari Aldo E Calogero | 2014 | Asian Journal of Andrology2014，16，5： | 3 |
| 4 | Liver angiogenesis as a risk factor for hepatocellularcarcinoma development in hepatitis C virus cirrhotic patients显示文摘AIM: To evaluate the predictive value of hepatocyte proliferation and hepatic angiogenesis for the occurrence of Hepatocellular carcinoma (HCC) in hepatitis C virus (HCV) cirrhotic patients. METHODS: One hundred-five patients (69 males, 36 females; age range, 51-90 year; median 66 year) with biopsy proven HCV cirrhosis were prospectively monitored for HCC occurrence for a median time of 64 mo. Angiogenesis was assessed by using microvessel density (MVD), hepatocyte turnover by MIB1 and PCNA indexes at inclusion in liver biopsies. RESULTS: Forty six patients (43.8%) developed HCC after a median time of 55 (6-120) mo while 59 (56.2%) did not. Patients were divided into two groups according to the median value of each index. The difference between patients with low (median MVD = 3; range 0-20) and high (median MVD = 7; range 1-24) MVD was statistically significant (χ2 = 22.06; P < 0.0001) which was not the case for MIB1 or PCNA (MIB-1: χ2 = 1.41; P = 0.2351; PCNA: χ2 = 1.27; P = 0.2589). The median MVD was higher in patients who developed HCC than in those who did not. HCC-free interval was significantly longer in patients with the MVD ≤ 4 (P = 0.0006). No relationship was found between MIB1 or PCNA and MVD (MIB-1 r2 = 0.00007116, P = 0.9281; PCNA: r2 =0.001950; P = 0.6692). MVD only was able to predict the occurrence of HCC in these patients. Among other known risk factors for HCC, only male sex was statistically associated with an increased risk. CONCLUSION: Liver angiogenesis has a role for in HCV- related liver carcinogenesis and for defining patients at higher risk. | Roberto Mazzanti Luca Messerini Camilla E Comin Lorenzo Fedeli Nathalie Gannè-Carrie Michel Beaugrand | 2007 | World Journal of Gastroenterology2007，13，37： | 3 |
| 5 | Operative Versus Nonoperative Treatment for Stage 0 Distal Rectal Cancer Following Chemoradiation Therapy: Long-term Results显示文摘 | Angelita Habr-Gama Rodrigo Oliva Perez Wladimir Nadalin Jorge Sabbaga Ulysses Ribeiro Afonso Henrique Silva e Sousa Fábio Guilherme Campos Desidério Roberto Kiss Joaquim Gama-Rodrigues | 2004 | Annals of Surgery2004，，4： | 2 |
| 6 | Monitoring of virgin olive oil volatile compounds evolution during olive malaxation by an array of metal oxide sensors 显示文摘 | Sonia E GianFrancesco M Roberto S | 2009 | Food Chemistry2009，113，1： | 1 |
| 7 | Dual-based heuristics for a hierarchical covering location problem 显示文摘 | Luis G Acosta E Roberto D G | 2003 | Computer & Operations Research2003，30，： | 1 |
| 8 | Development of process for far infrared sensor fabrication显示文摘 | ROBERTO R N IOSHIAKI D JOS E A D | 2006 | Sensors and Actuators A2006，132，： | 1 |
| 9 | A method for calibration and validation subset partitioning显示文摘 | ROBERTO K H G MARIO C U A GLEDSON E J | 2005 | Talanta2005，67，4： | 1 |
| 10 | Operation setting nomograms for Unidrench Venturi injector显示文摘 | Roberto V Montoya Y E | 2010 | Agronomia Colombiana2010，28，2： | 1 |
| 11 | Adaptation of the van Genuchten expression to the effects of empera- ture and density for compacted bentonites 显示文摘 | JACINTO A C VILLAR M V ROBERTO G E | 2009 | Applied Clay Science2009，42，34： | 1 |
| 12 | Clinical impact of on-site cytopathology interpretation on endoscopic ultrasound-guided fine needle aspiration显示文摘 | Jason B Klapman Roberto Logrono Charles E Dye Irving Waxman | 2003 | The American Journal of Gastroenterology2003，，6： | 1 |
| 13 | Modelling technical in Italian agriculture :a latentvariable approach 显示文摘 | Roberto E Pierpaolo P | 2000 | Agricultural Economics2000，22，3： | 1 |
| 14 | Direct analysis for design evaluation of partially restrained steel framing systems显示文摘 | ANDREA E S DONALD W W ROBERTO T L | 2005 | Journal of Structural Engineering ASCE2005，131，9： | 1 |
| 15 | Dual-based heuristics for a Hierarchical covering location problem显示文摘 | Luis G Acosta E Roberto D G | 2003 | Computers and Operations Research2003，30，： | 1 |
| 16 | Identification,isolation andin vitro expansion of human and nonhuman primate T stem cellmemory cells显示文摘 | Lugli E Gattinoni L Roberto A | 2013 | Nat Protoc2013，8，1： | 1 |
| 17 | Endothelial dysfunction:a comprehensive appraisal显示文摘 | Ricardo J E Roberto A N Qad F A | 2004 | Gen Intern Med2004，19，7： | 1 |
| 18 | mTORC1 senses ly- sosomal amino acids through an inside-out mechanism that re- quires the vacuolar H -F-ATPase 显示文摘 | ROBERTO Z LIRON B P ALEJO E | 2011 | Science2011，334，6056： | 1 |
| 19 | Anti HIV activity mediated by natural killer and CD8+ cells after Toll-like receptor 7/8 triggering显示文摘 | Schlaepfer E Roberto F | 2008 | PloS ONE2008，3，4： | 1 |
| 20 | Frequency estimation of real-valued single-tone in colored noise using multiple autocorrelation lags显示文摘 | RIM E K HICHEM B ROBERTO L V | 2010 | Signal Processing2010，90，7： | 1 |
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