维普期刊资源整合服务平台（V6.5）

480篇 您的检索式：作者名="Pol G"

选中清除导出查看参考文献查看引证文献引用追踪共24页首页上一页第1页下一页末页 /24 跳转

	题名	作者	年代	出处	被引量
1	Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model显示文摘AIM: To evaluate the antiviral potency of a new antihepatitis C virus(HCV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HCV Con1b/C3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HCV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HCV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HCV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 EC50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine EC50 = 1.17 μmol/L).CONCLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HCV infection in a dosedependent manner without cytotoxic effect.	Sylvie Lagaye Sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska Claire Camus Clarisse Dubray Géraldine Rousseau Pierre-Philippe Massault Jerome Courcambeck Firas Bassisi Philippe Halfon Stanislas Pol	2016	World Journal of Hepatology2016，8，21：	5
2	Mystery swine disease in the Netherlands:the isolation of Lelystad virus 显示文摘	Wensvoort G Terpstra C Pol J M	1991	Vet Q1991，13，3：	1
3	Comparative morphogenesis of three PRRS virus strains 显示文摘	Pol J M A Wagenaar F Reus J E G	1997	Vet Microbiol1997，55，14：	1
4	Advanced anaerobic wastewater treatment in the near future显示文摘	Lettinga G Field J Van Lier J B Zeeman G Pol L W H	1997	Wat Sci Technol1997，35，10：	1
5	Mystery swine disease in the NetherLands: isolation of Lelystad virus 显示文摘	Wensvoort G Terpstra C Pol J M	1991	Vet Q1991，13，3：	1
6	Mystery swine disease in The Netherlands: the isolation of Lelystad virus显示文摘	Wensvoort G Terpstra C Pol J M A	1991	Vet Q1991，13，：	1
7	Neuronspecific enolase as a marker of brain metastasis in patients with small-cell lung carcinoma显示文摘	Van de Pol M Tgwijnstra A Ten Velde G P	1994	J Neurooncol1994，19，2：	1
8	A piezoelectric micro-pump based on micro-machine of silicon显示文摘	Van Lintel H T G Vande De Pol F C M Bouwstra S	1988	Sensors and Actuators A: physical1988，15，13：	1
9	Biological sulphate reduction using gas-lift reactor fed with hydrogen and carbon dioxide as energy and carbon source显示文摘	van Houten R T Pol L W H Lettinga G	1994	Biotechnology and Bioengineering1994，44，5：	1
10	Characterization of the action of selected essential oil components on Gram-negative bacteria显示文摘	Helander I M Alakomi H L Latva-Kala K Mattila-Sandholm T Pol I Smid E J Gorris L G M Wright A	1998	Journal of Agricultural and Food Chemistry1998，46，9：	1
11	显示文摘	Pol V G Pol S V Calderon Moreno J M	2006	Carbon2006，44，15：	1
12	Moderate alcohol consumption and platelet aggregation in healthy middleaged men显示文摘	Van del Pol H Schaafsma G	1990	Alcohol1990，7，：	1
13	Mystery swine dis- ease in the Netherlands: the isolation of Lelystad virus显示文摘	Wensvoort G Terpstra C Pol JM	1991	Vet Q1991，13，3：	1
14	Which factors determine the sexual function 1 year aRer childbirth? 显示文摘	van Brummen HJ Bruinse HW van de Pol G	2006	B JOG2006，113，8：	1
15	显示文摘	Pol V G Motiei M Gedanken A	2004	Carbon2004，42，1：	1
16	Improving the high-temperature performance of LiMn204 spinel electrodes by coating the active mass with MgO via a sonochemical method 显示文摘	GNANARAJ J S POL V G GEDANKEN A	2003	Electrochemistry Communications2003，，5：	1
17	Genetic polymorphisms and clinical practice: the example of osteoporosis显示文摘	Pols HA Uitterlinden A G	2002	Acta Clin Belg2002，57，5：	1
18	Biological sulphate reduction using gas -lift reactors fed with hydrogen and carbon dioxide as energy and carbon source显示文摘	Pol L W H Lettinga G	1994	Biotechnol Bioeng1994，44，：	1
19	Microwave-assisted synthe- sis of tin sulfide nanoflakes and their electrochemical perform- ance as Li-inserting materials 显示文摘	Patra C R Odani A Pol V G	2002	J Solid State Eleetrochem2002，11，2：	1
20	Sonoehemical deposition of silver nanoparticles on silica spheres 显示文摘	Pol V G Srivastava D N Palchik O	2002	Langmuir2002，18，：	1

返回顶部每页显示：

共24页首页上一页第1页下一页末页 /24 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示