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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Surface roughness and its effects on the heat transfer mechanism in spray cooling 显示文摘 | Pais M R Chow L C Mathefdey E T | 1992 | ASME Journal of Heat Transfer1992，114，1： | 1 |
| 3 | 显示文摘 | Loureiro Jose M Rodrigues Alirio E | 1998 | Journal of Chromatography A1998，827，： | 1 |
| 4 | Do miniserews remain stationary under orthod ontic forces显示文摘 | Liou E J Pai B C Lin J C | 2004 | Am J Orthod Dentofacial Orthop2004，126，1： | 1 |
| 5 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 6 | 显示文摘 | Loureiro Jose M Rodrigues Alirio E | 2000 | Separation Purification Technology2000，20，： | 1 |
| 7 | Relationship between patient response in ovarian and breast cancer and platinum drug-DNA adduct formation显示文摘 | Gupta-Burt S Shamkhani H Reed E Tarone RE Allegra CJ Pai LH | 1993 | Cancer Epidemiol Biomarkers Prev1993，2，3： | 1 |
| 8 | Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia显示文摘 | Dandekar S Romanos-Sirakis E Pais F | 2014 | Br J Haematol2014，167，1： | 1 |
| 9 | Nanocarrier-mediated inhibition of macrophage migration inhibitory factor attenuates secondary injury after spinal cord injury显示文摘 | Saxena T Loomis KH Pai S Gaupp E Patil K Patkar R | 2015 | ACS Nano2015，9，2： | 1 |
| 10 | Preparation of surface-modified poly (butylene terephthalate) nonwovens and their application as leukocyte removal filters 显示文摘 | Kim E J Yeo GD Pai CM | 2009 | J Biomed Mater Res B Appl Biomater2009，90，2： | 1 |
| 11 | Two SOX9genes on duplicated zebrafish chromosomes:expression of similar transcription activators in distinct sites显示文摘 | Chiang E F Pai C I Wyatt M | 2001 | Dev Biol2001，231，1： | 1 |
| 12 | Identification and Catheter ablation of extracardiac and intracardiac components of Ligament of Marshall tissue for treatment of paroxysmal atrial fibrillation显示文摘 | Katritsis D John PAI Constantine E | 2001 | J Cardiovasc Electrophy siol2001，12，10： | 1 |
| 13 | Thresholds of step initiation induced by support-surface translation: a dynamic center-of-mass model provides much better prediction than a static model 显示文摘 | PAI Y-C Maki B E Iqbal K | 2000 | J of biomechanics2000，33，： | 1 |
| 14 | Effects of nattokinase,a pro-fibrinolytic enzyme,on red blood cell aggregation and whole blood viscosity显示文摘 | Pais E Alexy T Holsworth RE Jr | 2006 | Clin Hemorheol Microcirc2006，35，12： | 1 |
| 15 | Approximate formulas for dynamic stiffness of rigid foundations显示文摘 | Pais A Kausel E | 1988 | Soil Dynamics and Earthquake Eng1988，7，： | 1 |
| 16 | Low-calcium dialysate stimulates parathormone secretion and its long-term use worsens secondary hyperparathyroidism显示文摘 | Fernandez E Borras M Pais B | 1995 | J Am Soc Nephrol1995，6，1： | 1 |
| 17 | Abnormal blood theology and chronic low grade inflammation : possible risk factors for accelerated atherosclerosis and cor- onary artery disease in Lewis negative subjects 显示文摘 | AlexyT Pais E Wenby RB | 2015 | Atheroselerosis2015，239，1： | 1 |
| 18 | Decrease of insulin resistance after spirnectomy in a diabetic patient with liver cirrhosis and portal hypertension: physiopathologic evaluation显示文摘 | Moro E Pais M Benvegu M et el | 1994 | Minerva Gastroenterol Dietol(halian)1994，40，4： | 1 |
| 19 | 显示文摘 | Loureiro Jose M Rodrigues Alirio E | 1998 | AIChE Journal1998，44，3： | 1 |
| 20 | Surface roughness and its effects on the heat transfer mechanism in spray cooling显示文摘 | Pais M Chow L C Maheikey E | 1992 | Journal of Heat Transfer1992，114，1： | 1 |
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