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| 1 | Dynamic magnetic resonance defecography in 10 asymptomatic volunteers显示文摘AIM: Evaluation of the wide range of normal findings in asymptomatic women undergoing dynamic magnetic resonance (MR) defecography. METHODS: MR defecography of 10 healthy female volunteers (median age: 31 years) without previous pregnancies or history of surgery were evaluated. The rectum was filled with 180 mL gadolinium ultrasound gel mixture. MR defecography was performed in the supine position. The pelvic floor was visualized with a dynamic T2-weighted sagittal plane where all relevant pelvic floor organs were acquired during defecation. The volunteers were instructed to relax and then to perform straining maneuvers to empty the rectum. The pubococcygeal line (PCGL) was used as the line of reference. The movement of pelvic floor organs was measured as the vertical distance to this reference line. Data were recorded in the resting position as well as during the defecation process with maximal straining. Examinations were performed and evaluated by two experienced abdominal radiologists without knowledge of patient history. RESULTS: Average position of the anorectal junction was located at -5.3 mm at rest and -29.9 mm during straining. The anorectal angle widened significantly from 93° at rest to 109° during defecation. A rectocele was diagnosed in eight out of 10 volunteers showing an average diameter of 25.9 mm. The bladder base was located at a position of +23 mm at rest and descended to -8.1 mm during defecation in relation to the PCGL. The bladder base moved below the PCGL in six out of 10 volunteers, which was formally defined as a cystocele. The uterocervical junction was located at an average level of +43.1 mm at rest and at +7.9 mm during straining. The uterocervical junction of three volunteers fell below the PCGL; described formally as uterocervical prolapse. CONCLUSION: Based on the range of standard values in asymptomatic volunteers, MR defecography values for pathological changes have to be re-evaluated. | Andreas G Schreyer Christian Paetzel Alois Fürst Lena M Dendl Elisabeth Hutzel René Müller-Wille Philipp Wiggermann Stephan Schleder Christian Stroszczynski Patrick Hoffstetter | 2012 | World Journal of Gastroenterology2012，18，46： | 7 |
| 2 | Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer显示文摘 | Patrick C. Hermann Stephan L. Huber Tanja Herrler Alexandra Aicher Joachim W. Ellwart Markus Guba Christiane J. Bruns Christopher Heeschen | 2007 | Cell Stem Cell2007，，3： | 5 |
| 3 | Clinical End Points in Coronary Stent Trials: A Case for Standardized Definitions显示文摘 | Donald E. Cutlip Stephan Windecker Roxana Mehran Ashley Boam David J. Cohen Gerrit-Anne van Es P Gabriel Steg Marie-angèle Morel Laura Mauri Pascal Vranckx Eugene McFadden Alexandra Lansky Martial Hamon Mitchell W. Krucoff Patrick W. Serruys | 2007 | Circulation2007，，17： | 4 |
| 4 | Ontology Dynamics in a Data Life Cycle: Challenges and Recommendations from a Geoscience Perspective显示文摘Ontologies are increasingly deployed as a computer-accessible representation of key semantics in various parts of a data life cycle and, thus, ontology dynamics may pose challenges to data management and re-use. By using examples in the field of geosciences, we analyze challenges raised by ontology dynamics, such as heavy reworking of data, semantic heterogeneity among data providers and users, and error propagation in cross-discipline data discovery and re-use. We also make recommendations to address these challenges:(1) communities of practice on ontologies to reduce inconsistency and duplicated efforts;(2) use ontologies in the procedure of data collection and make them accessible to data users; and(3) seek methods to speed up the reworking of data in a Semantic Web context. | Xiaogang Ma Peter Fox Eric Rozell Patrick West Stephan Zednik | 2014 | Journal of Earth Science2014，25，2： | 3 |
| 5 | 弹性材料平头压痕试验的有限元模拟显示文摘压痕试验是近些年来材料力学中应用十分广泛的力学试验之一.本文通过对弹性材料平头压痕试验的有限元数值模拟,比较了荷载-位移曲线和接触面分布应力的理论解和数值解,验证了有限元模型的有效性,并对有限元数值模型的几何尺寸、网格疏密、边界条件等参数进行了敏感性分析.该有限元模型的建立为研究压痕试验的应用提供了一种有效的数值分析方法. | 王伟 Corn Stephane Ienny Patrick | 2009 | 三峡大学学报(自然科学版)2009，31，5： | 2 |
| 6 | Prevalence of autoantibodies and the risk of autoimmune thyroid disease in children with chronic hepatitis C virus infection treated with interferon-α显示文摘AIM: To evaluate the prevalence of autoantibodies in chronic hepatitis C virus (HCV)-infected children focusing on thyroid autoimmunity. METHODS: We investigated the prevalence of auto- antibodies in 123 chronic HCV-infected children before, during and after monotherapy with interferon-alpha (IFN-α) or combined treatment with interferon-α or peginterferon-α and ribavirin. Besides antibodies against smooth muscle (SMA), nuclei (ANA), and liver/kidney microsomes (LKM), the incidence of anti- thyroid peroxidase antibodies as well as thyroid function parameters (TSH, FT3 and FT4) were determined. RESULTS: We found that 8% of children had autoantibodies before treatment. During treatment, 18% of children were found positive for at least one autoantibody; 15.5% of children developed pathologic thyroid values during IFN-α treatment compared to only one child before therapy. Six children had to be substituted while developing laboratory signs of hypothyroidism. CONCLUSION: Our data indicate a strong correlation between interferon-α treatment and autoimmune phenomena, notably the emergence of thyroid antibodies. The fact that some children required hormone replacement underlines the need of close monitoring in particularly those who respond to therapy and have to be treated for more than 6 mo. | Stephan Gehring Ulrike Kullmer Sabine Koeppelmann Patrick Gerner Philip Wintermeyer Stefan Wirth | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 7 | Distinct popu-lations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic显示文摘 | Patrick CH Stephan LH Herrler TJ | 2007 | Cell Stem Cell2007，1，： | 1 |
| 8 | The influence of displacement on shoulder function in patients with minimally displaced fractures of the greater tuberosity显示文摘 | Platzer Patrick Kutseha-Lissberg Florian Lehr Stephan | 2005 | Injury2005，36，10： | 1 |
| 9 | Incremental diseoyery of object parts in video sequences显示文摘 | Stephane Drouin Patrick Hebert Marc Parizeau | 2008 | Computer Vision and Image Understanding2008，110，1： | 1 |
| 10 | Primary Gastric B-Cell Lymphoma: Results of a Prospective Multicenter Study显示文摘 | Wolfgang Fischbach* Brigitte Dragosics? Maria-Elisabeth Kolve-Goebeler§ Christian Ohmann∥ Axel Greiner? Qin Yang∥ Stephan B?hm? Patrick Verreet∥ Olaf Horstmann# Martin Busch** Eckhart Dühmke** Hans-Konrad Müller-Hermelink? Klaus Wilms§ | 2000 | Gastroenterology2000，，5： | 1 |
| 11 | 2-Year Follow-Up of Patients Undergoing Transcatheter Aortic Valve Implantation Using a Self-Expanding Valve Prosthesis显示文摘 | Lutz Buellesfeld Ulrich Gerckens Gerhard Schuler Raoul Bonan Jan Kovac Patrick W. Serruys Marino Labinaz Peter den Heijer Michael Mullen Wayne Tymchak Stephan Windecker Ralf Mueller Eberhard Grube | 2011 | Journal of the American College of Cardiology2011，，16： | 1 |
| 12 | Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer显示文摘 | Patrick C. Hermann Stephan L. Huber Tanja Herrler Alexandra Aicher Joachim W. Ellwart Markus Guba Christiane J. Bruns Christopher Heeschen | 2007 | Cell Stem Cell2007，，3： | 1 |
| 13 | Challenges and opportunities in mapping land use intensity globally显示文摘 | Tobias Kuemmerle Karlheinz Erb Patrick Meyfroidt Daniel Müller Peter H Verburg Stephan Estel Helmut Haberl Patrick Hostert Martin R. Jepsen Thomas Kastner Christian Levers Marcus Lindner Christoph Plutzar Pieter Johannes Verkerk Emma H van der Zanden Anet | 2013 | Current Opinion in Environmental Sustainability2013，，： | 1 |
| 14 | Acute mesenteric venous thrombosis: Case for nonoperative management显示文摘 | Laurent Brunaud Laurent Antunes Stephan Collinet-Adler Frederic Marchal Ahmet Ayav Laurent Bresler Patrick Boissel | 2001 | Journal of Vascular Surgery2001，，： | 1 |
| 15 | Phenotypic and functional characteristics of CD4<sup>+</sup>CD39<sup>+</sup> FOXP3<sup>+</sup> and CD4<sup>+</sup>CD39<sup>+</sup>FOXP3<sup>neg</sup> T‐cell subsets in cancer patients显示文摘 | Patrick J. Schuler Bastian Schilling Malgorzata Harasymczuk Thomas K. Hoffmann Jonas Johnson Stephan Lang Theresa L. Whiteside | 2012 | Eur J Immunol2012，，7： | 1 |
| 16 | Photodegradation of rhodamine B in aqueous solution via SiO 2 @TiO 2 nano-spheres显示文摘 | Patrick Wilhelm Dietmar Stephan | 2006 | Journal of Photochemistry & Photobiology, A: Chemistry2006，，： | 1 |
| 17 | Zinc deficiency in patients with chronic pancreatitis显示文摘BACKGROUND Zinc is a key element in numerous proteins and plays an important role in essential cell functions such as defense against free radicals and DNA damage repair. Chronic pancreatitis(CP) is a chronic inflammation with progressive fibrosis of pancreas ultimately resulting in pancreatic exocrine insufficiency(PEI),which is associated with malnutrition. Studies analyzing zinc levels in patients with CP are sparse and lead to conflicting results.AIM To investigate serum zinc levels in patients with CP of various etiologies.METHODS Between October 2015 and March 2018, patients with a diagnosis of CP were identified and recruited from the Pancreatic Outpatient Clinic at the Karolinska University Hospital in Stockholm, Sweden. Demographic, clinical and laboratory data were analyzed. Etiology of CP was determined according to the MANNHEIM classification system into the following etiological subcategories:alcohol consumption, nicotine consumption, hereditary factors, efferent pancreatic duct factors and immunological factors. Pancreatic exocrine function was defined as normal(fecal elastase 1 > 200 μg/g), mildly reduced(100-200μg/g) and severely reduced(fecal elastase 1 < 100 μg/g).RESULTS A total of 150 patients were included in the analysis. Zinc deficiency(< 11μmol/L) was present in 39(26.0%) of patients: 22 females and 17 males. In the group of patients with zinc deficiency, 76.7% of patients had an exocrine pancreatic insufficiency(FE-1 < 200 μg/g). Older age was significantly associated with low zinc levels. Following a univariate analysis, patients aged 60-69 and patients ≥ 70 years of age had a significantly higher prevalence of zinc deficiencies compared to patients < 40 years of age [OR: 3.8, 95%CI(1.08-13.4); P= 0.04]; [OR 6.26, 95%CI(1.94-20.2), P > 0.002]. Smoking and number of packyears were additionally associated with low zinc levels. The risk of zinc deficiency in current smokers and smokers with ≥ 20 pack-years was approximately three times higher compared to those who had never smoked.Gender, body mass index, etiology of CP, presence of diabetes mellitus, levels of glycated hemoglobin(HbA1 c), bone mineral density, alcohol intake and presence of PEI were not associated with low zinc levels.CONCLUSION Zinc deficiency is common in patients with CP and is significantly associated with age ≥ 60, smoking and the number of pack-years, but not with PEI. | Miroslav Vujasinovic AleksANDra Hedstr?m Patrick Maisonneuve Roberto Valente Henrik von Horn J-Matthias L?hr Stephan L Haas | 2019 | World Journal of Gastroenterology2019，25，5： | 1 |
| 18 | What information can be obtained by RHEED applied on polycrystallinc films 显示文摘 | STEPHANE A PATRICK F | 1995 | Surf Sci1995，360，： | 1 |
| 19 | Transient apical ballooning syndrome — clinical characteristics, ballooning pattern, and long-term follow-up in a Swiss population显示文摘 | Parham Eshtehardi Simon C. Koestner Patrick Adorjan Stephan Windecker Bernhard Meier Otto M. Hess Andreas Wahl Stéphane Cook | 2008 | International Journal of Cardiology2008，，： | 1 |
| 20 | Enhancement of aromatic quality of Muscat wine by the use of immobilized β-glucosidase 显示文摘 | YANNICK G PATRICK C STEPHANE P | 1997 | Journal of Biotechnology1997，55，： | 1 |
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