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| 1 | Thymidine kinase gene mutation leads to reduced virulence of pseudorabies virus显示文摘To explore correlation between the tk gene structure of pseudorabies virus (PRV) and its virulence, to study the effect of the gene mutation on PRV biological properties, and to investigate mechinism of reduced virulence, thymidine kinase (TK)-deficient mutant of pseudorabies virus strain Hubei (PRV HB) was isolated by selection for resistance to 5-bromodeoxyuridine. The tk genes of PRV HB and its TK mutant were cloned and sequenced. 1587 base pairs of the tk gene and flanking regions of wild-type (wt) virus were sequenced, which included an open reading frame (ORF) of 1098 bp encoding a protein of 366 amino acids. The ORF contained two 137-bp repeated sequences, which were connected by an adenosine. 1458 bp of the tk and flanking regions of TK- mutant were sequenced. Analysis of the tk gene sequence of TK mutant indicated that one of 137 bp repeated sequence and the connecting adenosine in the tk gene of the wt virus was deleted and a repeated sequence of 8 nucleotides (GCGCGCC) was inserted. All | Pan, ZS Zhang, CY Ding, JH Min, P | 2001 | Chinese Science Bulletin2001，46，23： | 2 |
| 2 | Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture显示文摘 | Pan W Quarles LD Song LH Yu YH Jiao C Tang HB Jiang CH Deng HW Li YJ Zhou HH Xiao ZS | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 3 | Effect of octreotide administration in the prophylaxis of post-ERCP pancreatitis and hyperamylasemia: a multicenter, placebo-controlled, randomized clinical trial显示文摘 | Li ZS Pan X Zhang WJ | 2007 | Am J Gastroenterol2007，102，1： | 1 |
| 4 | Effect of octreotide administration in the prophylaxis of post-ERCP pancreatitis and hyperamylasemia:A multicenter,placebo-controlled,randomized clinical trial显示文摘 | Pan X Zhang WJ | 2007 | Am J Gastroenterol2007，102，： | 1 |
| 5 | Effect of Octreotide ad-ministration in the prophylaxis of post-ERCP pancreatitisand hyperamylasemia:a multicenter,placebo-controlled,randomized clinical trial显示文摘 | Li ZS Pan X Zhang WJ et a1 | 2007 | Am J Gastroenterol2007，102，1： | 1 |
| 6 | Effect of octreotide administration in the prophylaxis of post - ERCP pancreatitis and hyperamylasemia: A multicenter, placebo - controlled, randomized clinical trial显示文摘 | Li ZS Pan X Zhang WJ | 2007 | Am J Gastroenterol2007，102，1： | 1 |
| 7 | Adenovirus-mediated gene transfer in the treatment of pancreatic cancer显示文摘 | Pan X Li ZS Xu GM | 2003 | Pancreas2003，26，3： | 1 |
| 8 | The myocardial protective effects of puerarin on STZ-induced diabetic rats显示文摘 | Pan ZY Bao ZS Wu ZM | 2009 | Fen Zi Xi Bao Sheng Wu Xue Bao2009，42，2： | 1 |
| 9 | Efect of octreotide adminis-tration in the prophylaxis of post - ERCP pancreatitis and hy- peramylasemia: a multicenter, placebo controlled, randomized clinical trial显示文摘 | Li ZS Pan X Zhang WJ | 2007 | Am J Gastroenterol2007，102，1： | 1 |
| 10 | Genistein stimulates theosteo blastic diferentiation via NO/eGMP in bo Be malTOW culture显示文摘 | Pan W Quarles LD Xiao ZS et a l | 2005 | J Cell Bio Chem2005，94，2： | 1 |
| 11 | Effect of octreotide ad- ministration in' the prophylaxis of post-ERCP pancreatitis and hyperamylasemia: a muhicenter, placebo-controlled, randomized clinical trial 显示文摘 | Li ZS Pan X Zhang W J | 2007 | Am J Gastroenterol2007，102，1： | 1 |
| 12 | Study of the methylation patterns of the EGFR gene promoter in non - small cell lung cancer显示文摘 | Pan ZY Jiang ZS Ouyang HQ | 2015 | Genet Mol Res2015，14，3： | 1 |
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