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| 1 | Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma显示文摘AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples.METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, β-catenin, p53, CD44, MSH-2,MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups.RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples.CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data onin vivo human tumors. | Dénes Grg János Regly-Mérei Sándor Paku László Kopper Péter Nagy | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 2 | Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes显示文摘 | Viktória László Katalin Dezs? Kornélia Baghy Veronika Papp Ilona Kovalszky Géza Sáfrány Snorri S. Thorgeirsson Peter Nagy Sándor Paku | 2008 | Histochemistry and Cell Biology2008，，5： | 2 |
| 3 | First steps of tumor-related angiogenesis显示文摘 | Paku S Paweletz N | 1991 | Lab Invest1991，65，： | 1 |
| 4 | Origin and structural evolution of the early proliferating oval cells in rat liver显示文摘 | PAKU S SCHNUR J NAGY P | 2001 | Am J Pathol2001，158，4： | 1 |
| 5 | Loss of vascular adhesion protein-1 expression inintra-tumoral microvessels of human skin melanoma显示文摘 | Forster-Horvath C Dome B Paku S Laddnyi A Somlai B’Jal-kanen S | 2004 | Mela-noma i2es2004，14，2： | 1 |
| 6 | Vascularization of cutaneous melanoma involves vessel cooption and has clinical significance显示文摘 | Dome B Paku S Somlai B | 2002 | The Journal of Pathology2002，197，3： | 1 |
| 7 | Antiprolifemtive effica- cy of the somatostatin analogue TT - 232 in human melanoma cells and tumours显示文摘 | Schwab RE Froidevaux S Paku S | 2001 | Anticancer Res2001，，： | 1 |
| 8 | Origin and structural evolution of the early proliferating oval cells in rat liver显示文摘 | Paku S Schnur J Nagg P | 2001 | AmJ Pathol2001，158，4： | 1 |
| 9 | Phase transitions of rat stratum corneum lipids by an electron paramagnetic resonance study and relationship of phase states to drug penetration显示文摘 | Ogiso H Paku T | 1996 | Biochimicaet Biophysica Acta (BBA)-Lipids and Lipid Metab1996，1301，12： | 1 |
| 10 | Antiproliferative effiCacy of the somatostatiatin alogue TT -232 in human melanoma cell and tumours显示文摘 | Schwab RE Froidevaux S Paku D | 2001 | AntiCancer Res2001，21，： | 1 |
| 11 | The effect of lentinan on the metastasis of Lewis lung carcinoma显示文摘 | Lapis K Papay J Paku S | 1989 | Int J Immunother1989，11，5： | 1 |
| 12 | Claudin-1 ,-3 and -4 proteins and mRNA expression in benign and malignant breast tesions:a research study显示文摘 | Tokes AM Kulka J Paku S | 2005 | Breast Cancer Res2005，7，2： | 1 |
| 13 | Development of the vascula ture in 'pushing-type' liver metastases of an experimen tal colorectal caneer显示文摘 | Paku S Kopper L Nagy P | 2005 | Int J Cancer2005，115，89： | 1 |
| 14 | Alternative vascularization mechanisms in cancer: pathology and therapeutic implications 显示文摘 | Dome B Hendrix MJ Paku S | 2007 | Am J Pathol2007，170，1： | 1 |
| 15 | Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study显示文摘 | Tokes AM Kulka J Paku S | 2005 | Breast Cancer Res2005，7，2： | 1 |
| 16 | Origin and Structaral Evolution of the early proliferating oval cells in rat liver显示文摘 | S Paku J Sshnur P Nagy | 2001 | Am J Pathol2001，158，： | 1 |
| 17 | Mechanism of the enhancement effect of n-Octyl-β-D-thioglucoside on the transdermal penetration of fluorescein isothiocyanate-labeled dextrans and the molecular weight dependence of water-soluble penetrants through stripped skin显示文摘 | Ogiso T Paku T Iwaki M | 1994 | J Pharm Sci1994，83，12： | 1 |
| 18 | Origin and structural evolution of the early proliferating oval cells in rat liver显示文摘 | PAKU S SCHNUR J NAGY P | 2001 | Am J Pathol2001，158，4： | 1 |
| 19 | Expression and secretion of neuroleukin/phosphohexose isomerase/maturation factor as autocrine motility factor by tumor cells显示文摘 | Paku S Haga A | 1998 | Cancer Res1998，，： | 1 |
| 20 | Matlab/Simulink/Sim-Power- Systems model for a PWM AC-to-DC converter with line conditioning capabilities显示文摘 | Paku R Marschalko R | 2010 | Electrotehnica2010，51，2： | 1 |
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