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| 1 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | Vertebroplasty and Kyphoplasty: A Systematic Review of 69 Clinical Studies显示文摘 | Paul A. Hulme J?rg Krebs Stephen J. Ferguson Ulrich Berlemann | 2006 | Spine2006，，17： | 2 |
| 3 | A description of seed potato systems in Kenya, Uganda and Ethiopia 显示文摘 | PETER RG PAUL D IAN B eta/ | 2009 | Am J Pot Res2009，，86： | 1 |
| 4 | Glycosylation of collagen:the basis of its central role in the late complication of aging and diabetes显示文摘 | Paul RG Bailey AJ | 1996 | Int J Biochem Cell Biol1996，28，12： | 1 |
| 5 | Simultaneous nitrification and denitrification in bench-scale sequencing batch reactors显示文摘 | Elisabethv Münch Paul Lant Jürg Keiier | 1996 | Water Sci Technol1996，30，2： | 1 |
| 6 | Regulation of intestinal blood flow 显示文摘 | Paul JM Mark AW Neal RG | 2000 | J Surg Res2000，93，1： | 1 |
| 7 | Melanie rug a newlydiscovered protein export machine in malaria parasites显示文摘 | Tania F de Koning-Ward Paul RG | 2009 | Na-ture2009，，： | 1 |
| 8 | Simultaneous nitrification and denitrification in bench-scale sequencing batch reactors显示文摘 | Elisabeth V Münch Paul Lant Jürg Keller | 1996 | Wat Sci Tech1996，30，28： | 1 |
| 9 | Simultaneous nitrification and denitrification in bench-scale sequencing batch reactors显示文摘 | Elisabeth V. Münch Paul Lant Jürg Keller | 1996 | Water Research1996，，2： | 1 |
| 10 | Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response显示文摘 | Dazert Eva Neumann-Haefelin Christoph Bressanelli Stéphane Fitzmaurice Karen Kort Julia Timm J?rg McKiernan Susan Kelleher Dermot Gruener Norbert Tavis John E Rosen Hugo R Shaw Jaqueline Bowness Paul Blum Hubert E Klenerman Paul Bartenschla | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 11 | Tribological Properties of Nanocomposite CrC x /a-C:H Thin Films显示文摘 | Gert Gassner J?rg Patscheider Paul H. Mayrhofer Saso ?turm Christina Scheu Christian Mitterer | 2007 | Tribology Letters2007，，1： | 1 |
| 12 | A Randomized, Placebo-Controlled Study of the Effects of Denosumab for the Treatment of Men with Low Bone Mineral Density显示文摘 | Eric Orwoll Christence S. Teglbj?rg Bente L. Langdahl Roland Chapurlat Edward Czerwinski David L. Kendler Jean-Yves Reginster Alan Kivitz E. Michael Lewiecki Paul D. Miller Michael A. Bolognese Michael R. McClung Henry G. Bone ?sten Ljunggren Bo Abrahamse | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，9： | 1 |
| 13 | Simultaneous nitrification and denitrification in bench-scale sequencing batch reactors显示文摘 | Elisabeth V Mu nch Paul Lant Ju rg Keller | 1996 | Water Research1996，2，30： | 1 |
| 14 | The effect of advanced glycation end-product formation upon cell-matrix interactions显示文摘 | Paul RG Bailey AJ | 1999 | Int J Biochem Cell Biol1999，31，： | 1 |
| 15 | Simultaneous nitrification and denitrification in bench-scale sequencing batch reactor显示文摘 | Elisabeth V Münch Paul Lant Jürg Keller | 1996 | Water Res1996，30，2： | 1 |
| 16 | Diode-pumped,electro-optically Q-switched,cryogenic Tm:YAG laser operating at 1.88 μm显示文摘We present a diode-pumped, electro-optically Q-switched Tm:YAG laser with a cryogenically cooled laser crystal at120 K. Output pulses of up to 2.55 mJ and 650 ns duration were demonstrated in an actively Q-switched configuration with a repetition rate of 1 Hz. By using cavity dumping the pulse duration was shortened to 18 ns with only a slightly lower output energy of 2.22 mJ. Furthermore, using a simplified rate equation model, we discuss design constraints on the pump fluence in a pulse pump approach for Tm:YAG to maximize the energy storage capability at a given pump power. | Jörg Körner Venkatesan Jambunathan Fangxin Yue Jürgen Reiter Ondrej Slezák Petr Navrátil Samuel Paul David Antonio Lucianetti Joachim Hein TomášMocek Malte CKaluza | 2021 | High Power Laser Science and Engineering2021，9，1： | 1 |
| 17 | Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response显示文摘 | Dazert Eva Neumann-Haefelin Christoph Bressanelli Stéphane Fitzmaurice Karen Kort Julia Timm J?rg McKiernan Susan Kelleher Dermot Gruener Norbert Tavis John E Rosen Hugo R Shaw Jaqueline Bowness Paul Blum Hubert E Klenerman Paul Bartenschla | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 18 | Vertebroplasty and Kyphoplasty: A Systematic Review of 69 Clinical Studies显示文摘 | Paul A. Hulme J?rg Krebs Stephen J. Ferguson Ulrich Berlemann | | Spine0，，： | 1 |
| 19 | Pathogenesis of idiopathic pul-monary fibrosis 显示文摘 | Paul JW Harold RG Kirk DJ | 2014 | Annu Rev Pathol Mech Dis2014，9，1： | 1 |
| 20 | Key site variables governing the functional characteristics of Dissolved Natural Organic Matter (DNOM) in Nordic forested catchments显示文摘 | Rolf D. Vogt Jarkko Akkanen Dag Olav Andersen Rainer Brüggemann Bimal Chatterjee Egil Gjessing Jussi V. K. Kukkonen H?kon E. Larsen J?rg Luster Andrea Paul Stephan Pflugmacher Mike Starr Christian E. W. Steinberg Philippe Schmitt-Kopplin ádám Zsolnay | 2004 | Aquatic Sciences2004，，2： | 1 |
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