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| 1 | 低浓度混苯对女工生殖激素分泌的影响显示文摘目的 探讨低浓度混苯作业对女工月经周期生殖激素分泌的影响。方法 对 5 0名暴露组女工采用气相色谱法测定呼吸带空气中的苯、甲苯和二甲苯的浓度 ,对暴露组女工及外对照组和内对照组女工各 35名进行月经周期特征前瞻性调查 ,用酶免疫分析法测定尿液中的孕二醇 3 葡糖苷酸 (PdG)、雌酮结合物 (E1C)和卵泡刺激素 (FSH)。结果 空气中混苯以低浓度苯为主 ,苯检出率2 9 10 %、浓度 8 88(0 90~ 876 47)mg/m3 、超标率 2 1%、最大超标倍数 2 0 91倍 ;与内对照组和外对照组相比 ,低浓度混苯接触组女工黄体期长度缩短 ;与内对照组相比 ,暴露组的排卵前E1C水平、卵泡早期FSH水平以及卵泡早期和黄体期PdG水平明显降低。结论 低浓度混苯可以干扰接触女工下丘脑 垂体 卵巢轴中FSH、雌激素和孕激素的正常水平目的 探讨低浓度混苯作业对女工月经周期生殖激素分泌的影响。方法 对 5 0名暴露组女工采用气相色谱法测定呼吸带空气中的苯、甲苯和二甲苯的浓度 ,对暴露组女工及外对照组和内对照组女工各 35名进行月经周期特征前瞻性调查 ,用酶免疫分析法测定尿液中的孕二醇 3 葡糖苷酸 (PdG)、雌酮结合物 (E1C)和卵泡刺激素 (FSH)。结果 空气中混苯以低浓度苯为主 ,苯检出率2 9 10 %、浓度 8 88(0 90~ 876 | 陈海燕 王心如 徐莉春 Lasley BL Overstreet JW 戴建国 张绮 邢厚恂 杜冰 徐希平 | 2001 | 中华预防医学杂志2001，35，2： | 16 |
| 2 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 3 | Bioreduction of nitrate in groundwater using a pilot-scale hydrogen-based membrane biofilm reactor显示文摘A long-term pilot-scale H_(2)-based membrane biofilm reactor(MBfR)was tested for removal of nitrate from actual groundwater.A key feature of this secondgeneration pilot MBfR is that it employed lower cost polyester hollow fibers and still achieved high loading rate.The steady-state maximum nitrate surface loading at which the effluent nitrate and nitrite concentrations were below the Maximum Contaminant Level(MCL)was at least 5.9 g·N·(m^(2)·d)^(–1),which corresponds to a maximum volumetric loading of at least 7.7 kg·N·(m^(3)·d)^(–1).The steady-state maximum nitrate surface area loading was higher than the highest nitrate surface loading reported in the firstgeneration MBfRs using composite fibers(2.6 g·N·(m^(2)·d)^(–1)).This work also evaluated the H_(2)-utilization efficiency in MBfR.The measured H_(2)supply rate was only slightly higher than the stoichiometric H_(2)-utilization rate.Thus,H_(2)utilization was controlled by diffusion and was close to 100%efficiency,as long as biofilm accumulated on the polyester-fiber surface and the fibers had no leaks. | Youneng TANG Michal ZIV-EL Chen ZHOU Jung Hun SHIN Chang Hoon AHN Kerry MEYER Daniel CANDELARIA David FRIESE Ryan OVERSTREET Rick SCOTT Bruce ERITTMANN | 2010 | Frontiers of Environmental Science & Engineering2010，4，3： | 4 |
| 4 | Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones 显示文摘 | HELLSTROM W J OVERSTREET J W YU A | 2003 | Urology2003，170，： | 1 |
| 5 | Rickettsia and mollicute infections in hapatopancreatic cells of cultured Pacific white shrimp (Penaeus vannamei)显示文摘 | Krol R M Hawkins W E Overstreet R M | 1991 | J Invertebr Pathol1991，59，： | 1 |
| 6 | Assessment of human sperm function after recovery from the female reproductive tract 显示文摘 | Gould JE Overstreet JW Hanson FW | 1984 | Biol Reprod1984，31，： | 1 |
| 7 | Sperm morphol- ogy, motility, and concentration in fertile and infertile men 显示文摘 | Guzick DS Overstreet JW Factor-Litvak P | 2001 | N Engl J Med2001，345，19： | 1 |
| 8 | Distinct contri-butions of human hippocampal theta to spatial cognitionand anxiety显示文摘 | Cornwell BR Arkin N Overstreet C | 2012 | Hippocampus2012，22，9： | 1 |
| 9 | An internet based real-time control engineering laboratory显示文摘 | OVERSTREET J W TZES A | 1999 | IEEE Control Systems1999，19，5： | 1 |
| 10 | Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression显示文摘 | Overstreet DH Keeney A Hogg S | 2004 | Eur J Pharmacol2004，492，23： | 1 |
| 11 | Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones显示文摘 | Hellstrom W J Overstreet J W Yu A | 2003 | Urology2003，170，： | 1 |
| 12 | Penetration of the zona pellucida of nonliving human oocytes by human spermatozoa in vitro显示文摘 | Overstreet JW Hembree WC | 1976 | Fertil Steril1976，27，7： | 1 |
| 13 | Effects of sweetened ethanol so- lutions on ethanolself- administration and blood ethanol levels 显示文摘 | Matthews DB Overstreet DH | 2001 | Pharmacology Biochemistry and Behavior2001，68，1： | 1 |
| 14 | Sperm morphology, motility, and concentration in fertile and infertile men 显示文摘 | Guzick DS Overstreet JW Factor-Litvak P | 2001 | N Engl J Med2001，345，19： | 1 |
| 15 | Reconstructing a binary tree from its traversals in doubly logarithmic CREW time显示文摘 | Olariu S Overstreet M Wen Z F | 1995 | Journal of Parallel and Distributed Computing1995，27，1： | 1 |
| 16 | Depressive-like behavior and high alcohol drinking co-occur in the FH/Wjd rat but appear to be under independent genetic control显示文摘 | OVERSTREET DH REZVANI AH DJOUMA E | 2007 | Neurosci Biobehav Rev2007，31，1： | 1 |
| 17 | Paternal effects from methamidophos administration in mice显示文摘 | Burruel VR Raabe OG Overstreet JW | 2000 | Toxi and Appl Pharma2000，165，： | 1 |
| 18 | A comparison of eural networks and linear scoring models in the credit union environment显示文摘 | Desai V S Crook J N Overstreet G A | 1996 | European Journal of Operational Research1996，18，： | 1 |
| 19 | Sperm morphology, motility, and concentration in fertile and infertile men显示文摘 | Guzick DS Overstreet JW Factor-Litvak P | | NEngIJMed0，，19： | 1 |
| 20 | Genetic serotonin deficiency and alcohol preference in the Fawn-Hooded rats显示文摘 | REZVANI AH OVERSTREET DH JANOWSKY DS | 1990 | Alcohol Alcohol1990，25，5： | 1 |
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